Gene Page: SRA1

Summary ?
GeneID10011
SymbolSRA1
SynonymsSRA|SRAP|STRAA1|pp7684
Descriptionsteroid receptor RNA activator 1
ReferenceMIM:603819|HGNC:HGNC:11281|Ensembl:ENSG00000213523|HPRD:18716|Vega:OTTHUMG00000163569
Gene typeprotein-coding
Map location5q31.3
Pascal p-value4.185E-4
Fetal beta-0.639
eGeneCortex
Frontal Cortex BA9
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TELO20.740.76
PCNXL30.730.74
MAPK1IP1L0.730.73
SMPD40.730.74
ZC3HAV1L0.730.73
WIZ0.720.78
FZR10.720.78
CUL70.720.75
ARVCF0.720.76
ZNF5980.720.75
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.59-0.70
MT-CO2-0.59-0.72
AF347015.27-0.59-0.72
MT-CYB-0.58-0.71
AF347015.33-0.58-0.71
AF347015.8-0.57-0.72
C5orf53-0.56-0.63
AF347015.21-0.55-0.75
AF347015.2-0.54-0.70
AF347015.15-0.54-0.68

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0003677DNA bindingIEA-
GO:0005515protein bindingISS-
GO:0030374ligand-dependent nuclear receptor transcription coactivator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0008283cell proliferationIDA14517287 
GO:0006915apoptosisIDA14517287 
GO:0030154cell differentiationIDA14517287 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12565891 
GO:0005667transcription factor complexIEA-
GO:0005737cytoplasmIEA-
GO:0030529ribonucleoprotein complexIPI10199399 
GO:0031252cell leading edgeIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA CARM ER PATHWAY 3527All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 5843All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY 6537All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186114All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway