SZGR2

Summary ?

GeneID	10197
Symbol	PSME3
Synonyms	HEL-S-283\|Ki\|PA28-gamma\|PA28G\|PA28gamma\|REG-GAMMA
Description	proteasome activator subunit 3
Reference	MIM:605129\|HGNC:HGNC:9570\|Ensembl:ENSG00000131467\|HPRD:05500\|Vega:OTTHUMG00000180654
Gene type	protein-coding
Map location	17q21
Pascal p-value	0.188
Sherlock p-value	0.369
Fetal beta	-0.177
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	2
Expression	Meta-analysis of gene expression	P value: 1.812
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 3.5985

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg20760063	17	41277580	PSME3	7.082E-4	2.627		DMG:vanEijk_2014
cg20760063	17	41277580	PSME3	7.321E-4	2.258		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008538	proteasome activator activity	IEA		-
GO:0042802	identical protein binding	IPI		16169070
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	EXP		11285280
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	EXP		15029244
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	EXP		12791267
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000502	proteasome complex	TAS		8811196
GO:0005829	cytosol	IEA		-
GO:0008537	proteasome activator complex	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAP1	CENTA1 \| GCS1L \| p42IP4	ArfGAP with dual PH domains 1	Two-hybrid	BioGRID	16169070
ATP5B	ATPMB \| ATPSB \| MGC5231	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	Two-hybrid	BioGRID	16169070
BBS2	BBS \| MGC20703	Bardet-Biedl syndrome 2	Two-hybrid	BioGRID	16189514
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
HSPA5	BIP \| FLJ26106 \| GRP78 \| MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Two-hybrid	BioGRID	16169070
ITPKB	IP3K \| IP3K-B \| IP3KB \| PIG37	inositol 1,4,5-trisphosphate 3-kinase B	Two-hybrid	BioGRID	16189514
KIAA1267	DKFZp686P06109 \| DKFZp727C091 \| MGC102843	KIAA1267	Two-hybrid	BioGRID	16189514
MCC	DKFZp762O1615 \| FLJ38893 \| FLJ46755 \| MCC1	mutated in colorectal cancers	Affinity Capture-MS	BioGRID	17353931
NUDT18	FLJ22494	nudix (nucleoside diphosphate linked moiety X)-type motif 18	Two-hybrid	BioGRID	16189514
PSME3	Ki \| PA28-gamma \| PA28G \| REG-GAMMA	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	Two-hybrid	BioGRID	16169070 \|16189514
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	Affinity Capture-MS	BioGRID	17353931
SERF2	4F5REL \| FAM2C \| FLJ20431 \| FLJ37527 \| FLJ38557 \| H4F5rel \| HsT17089 \| MGC48826	small EDRK-rich factor 2	Two-hybrid	BioGRID	16189514
WDR25	MGC4645	WD repeat domain 25	Two-hybrid	BioGRID	16189514
ZCCHC10	FLJ20094	zinc finger, CCHC domain containing 10	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PROTEASOME	48	28	All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN	81	55	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN	59	40	All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS UP	67	40	All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 DN	56	32	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5	94	59	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN	110	64	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN	49	38	All SZGR 2.0 genes in this pathway
WONG PROTEASOME GENE MODULE	49	35	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN	50	36	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11	103	68	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN	254	158	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE ALL DN	25	14	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-15/16/195/424/497	992	998	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-186	1607	1613	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-30-5p	162	168	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-328	5	11	m8	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-378	184	190	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-490	249	255	m8	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-495	58	65	1A,m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	1600	1606	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-7	1178	1184	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PSME3