Gene Page: SLC22A7

Summary ?
GeneID10864
SymbolSLC22A7
SynonymsNLT|OAT2
Descriptionsolute carrier family 22 member 7
ReferenceMIM:604995|HGNC:HGNC:10971|Ensembl:ENSG00000137204|HPRD:05409|Vega:OTTHUMG00000014726
Gene typeprotein-coding
Map location6p21.1
Pascal p-value1.427E-5
eGeneHippocampus

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
ExpressionMeta-analysis of gene expressionP value: 1.577 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ABCF20.910.91
NPEPPS0.910.90
RABGEF10.910.91
CS0.910.91
XPO70.910.92
ZFYVE10.910.92
PDXDC10.910.91
NNT0.910.90
ADD10.910.92
POLR3A0.910.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.80-0.87
MT-CO2-0.80-0.82
AF347015.31-0.80-0.82
AF347015.8-0.78-0.81
AF347015.27-0.77-0.81
MT-CYB-0.77-0.79
AF347015.33-0.77-0.78
HIGD1B-0.76-0.80
IFI27-0.75-0.79
FXYD1-0.75-0.80

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005215transporter activityIEA-
GO:0008514organic anion transmembrane transporter activityIEA-
GO:0015347sodium-independent organic anion transmembrane transporter activityTAS9650585 
GO:0015075ion transmembrane transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0015711organic anion transportTAS9650585 
GO:0006811ion transportIEA-
GO:0006810transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS9650585 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9650585 
GO:0016323basolateral plasma membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 8954All SZGR 2.0 genes in this pathway
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT 139All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 10869All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP 5139All SZGR 2.0 genes in this pathway