Gene Page: TTC8
Summary ?
| GeneID | 123016 |
| Symbol | TTC8 |
| Synonyms | BBS8|RP51 |
| Description | tetratricopeptide repeat domain 8 |
| Reference | MIM:608132|HGNC:HGNC:20087|Ensembl:ENSG00000165533|Vega:OTTHUMG00000170884 |
| Gene type | protein-coding |
| Map location | 14q31.3 |
| Pascal p-value | 0.011 |
| Sherlock p-value | 0.425 |
| Fetal beta | -1.152 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | Meta-analysis of gene expression | P value: 2.116 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SR140 | 0.89 | 0.88 |
| TOPORS | 0.89 | 0.89 |
| JRKL | 0.89 | 0.87 |
| ZNF607 | 0.89 | 0.88 |
| AC104117.1 | 0.89 | 0.85 |
| NOL8 | 0.88 | 0.88 |
| ZNF225 | 0.88 | 0.88 |
| ZNF180 | 0.88 | 0.86 |
| ZNF568 | 0.88 | 0.87 |
| CTR9 | 0.88 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.70 | -0.76 |
| AF347015.31 | -0.69 | -0.78 |
| MT-CO2 | -0.69 | -0.78 |
| HLA-F | -0.69 | -0.72 |
| AF347015.33 | -0.68 | -0.76 |
| AF347015.8 | -0.66 | -0.76 |
| FXYD1 | -0.66 | -0.75 |
| MT-CYB | -0.66 | -0.74 |
| AF347015.15 | -0.66 | -0.76 |
| IFI27 | -0.65 | -0.76 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005488 | binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 14520415 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0030030 | cell projection organization | IEA | axon (GO term level: 7) | - |
| GO:0007601 | visual perception | IEA | - | |
| GO:0042384 | cilium biogenesis | TAS | 14520415 | |
| GO:0050896 | response to stimulus | IEA | - | |
| GO:0050893 | sensory processing | TAS | 14520415 | |
| GO:0048560 | establishment of anatomical structure orientation | IMP | 14520415 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005813 | centrosome | IDA | 14520415 | |
| GO:0005813 | centrosome | IEA | - | |
| GO:0005932 | basal body | IDA | 14520415 | |
| GO:0034464 | BBSome | IDA | 17574030 | |
| GO:0044441 | cilium part | IDA | 14520415 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| LOCKWOOD AMPLIFIED IN LUNG CANCER | 214 | 139 | All SZGR 2.0 genes in this pathway |
| BILD HRAS ONCOGENIC SIGNATURE | 261 | 166 | All SZGR 2.0 genes in this pathway |
| NAKAMURA METASTASIS MODEL DN | 43 | 28 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN | 321 | 200 | All SZGR 2.0 genes in this pathway |