Gene Page: DAB1
Summary ?
| GeneID | 1600 |
| Symbol | DAB1 |
| Synonyms | - |
| Description | Dab, reelin signal transducer, homolog 1 (Drosophila) |
| Reference | MIM:603448|HGNC:HGNC:2661|HPRD:04582| |
| Gene type | protein-coding |
| Map location | 1p32-p31 |
| Fetal beta | 2.709 |
| DMG | 1 (# studies) |
| eGene | Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.02692 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 7.813 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02774129 | 1 | 58712062 | DAB1 | 2.034E-4 | 0.42 | 0.035 | DMG:Wockner_2014 |
| cg08945467 | 1 | 58522070 | DAB1 | 3.441E-4 | 0.301 | 0.041 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | DAB1 | 1600 | 6.996E-4 | trans | ||
| rs17029291 | chr3 | 32402138 | DAB1 | 1600 | 0.03 | trans | ||
| rs4841493 | chr8 | 6521431 | DAB1 | 1600 | 0.15 | trans | ||
| rs16955618 | chr15 | 29937543 | DAB1 | 1600 | 0 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF862 | 0.90 | 0.91 |
| POLS | 0.89 | 0.93 |
| INTS3 | 0.89 | 0.92 |
| DHX16 | 0.89 | 0.92 |
| JARID2 | 0.88 | 0.90 |
| KDM2A | 0.88 | 0.93 |
| DIAPH1 | 0.88 | 0.93 |
| ZMYM3 | 0.88 | 0.94 |
| MEN1 | 0.88 | 0.92 |
| MBTPS1 | 0.88 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.75 | -0.84 |
| MT-CO2 | -0.73 | -0.83 |
| AF347015.27 | -0.71 | -0.79 |
| AF347015.33 | -0.71 | -0.78 |
| AF347015.8 | -0.70 | -0.81 |
| MT-CYB | -0.70 | -0.78 |
| FXYD1 | -0.69 | -0.77 |
| HIGD1B | -0.69 | -0.82 |
| AF347015.21 | -0.69 | -0.87 |
| S100B | -0.68 | -0.75 |
Section III. Gene Ontology annotation
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0007399 | nervous system development | IEA | neurite (GO term level: 5) | - |
| GO:0007275 | multicellular organismal development | IEA | - | |
| GO:0030154 | cell differentiation | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| APLP1 | APLP | amyloid beta (A4) precursor-like protein 1 | - | HPRD,BioGRID | 10460257 |
| APLP2 | APPH | APPL2 | CDEBP | amyloid beta (A4) precursor-like protein 2 | - | HPRD,BioGRID | 10460257 |
| APP | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD,BioGRID | 10460257 |
| APP | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD | 9837937 |10460257 |
| CRK | CRKII | v-crk sarcoma virus CT10 oncogene homolog (avian) | - | HPRD | 15062102 |
| DAB2IP | AF9Q34 | AIP1 | DIP1/2 | FLJ39072 | KIAA1743 | DAB2 interacting protein | - | HPRD | 11812785 |
| LDLR | FH | FHC | low density lipoprotein receptor | Reconstituted Complex Two-hybrid | BioGRID | 9837937 |10827173 |
| LDLR | FH | FHC | low density lipoprotein receptor | - | HPRD | 10380922 |
| LRP1 | A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | - | HPRD,BioGRID | 10827173 |
| LRP2 | DBS | gp330 | low density lipoprotein-related protein 2 | - | HPRD,BioGRID | 10827173 |
| LRP8 | APOER2 | HSZ75190 | MCI1 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | - | HPRD | 10380922 |
| LRP8 | APOER2 | HSZ75190 | MCI1 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | Two-hybrid | BioGRID | 10827173 |
| MYO6 | DFNA22 | DFNB37 | KIAA0389 | myosin VI | Reconstituted Complex | BioGRID | 11967127 |
| PAFAH1B1 | LIS1 | LIS2 | MDCR | MDS | PAFAH | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | - | HPRD | 14578885 |
| PCDH18 | DKFZp434B0923 | KIAA1562 | PCDH68L | protocadherin 18 | - | HPRD | 11716507 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD | 15062102 |
| RELN | PRO1598 | RL | reelin | - | HPRD | 11137154 |
| SIAH1 | FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1 | seven in absentia homolog 1 (Drosophila) | - | HPRD,BioGRID | 12646221 |
| VLDLR | CHRMQ1 | FLJ35024 | VLDLRCH | very low density lipoprotein receptor | - | HPRD | 10380922 |
| VLDLR | CHRMQ1 | FLJ35024 | VLDLRCH | very low density lipoprotein receptor | Two-hybrid | BioGRID | 10827173 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID REELIN PATHWAY | 29 | 29 | All SZGR 2.0 genes in this pathway |
| PID LIS1 PATHWAY | 28 | 22 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| CHEBOTAEV GR TARGETS DN | 120 | 73 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM3 | 70 | 37 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE UP | 60 | 42 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| OUYANG PROSTATE CANCER PROGRESSION DN | 21 | 16 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN | 157 | 106 | All SZGR 2.0 genes in this pathway |