Gene Page: FCGR3B

Summary ?
GeneID2215
SymbolFCGR3B
SynonymsCD16|CD16b|FCG3|FCGR3|FCR-10|FCRIII|FCRIIIb
DescriptionFc fragment of IgG receptor IIIb
ReferenceMIM:610665|HGNC:HGNC:3620|Ensembl:ENSG00000162747|HPRD:09951|Vega:OTTHUMG00000074099
Gene typeprotein-coding
Map location1q23
eGeneMeta
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
FCGR3Bchr1161594360AGNM_000570
NM_001244753
NM_001271035
NM_001271036
NM_001271037		p.216V>A
p.252V>A
p.251V>A
p.199V>A
p.113V>A		missense
missense
missense
missense
missense		SchizophreniaDNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RCN20.780.78
PAIP20.740.73
GFM20.720.68
MRPL190.720.70
RAB4A0.720.70
DNAJB90.720.73
SRPRB0.720.66
DNAJA30.710.69
PTPLAD10.710.69
SLC25A30.710.66
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.18-0.52-0.31
AF347015.21-0.47-0.24
AC010300.1-0.47-0.41
AC100783.1-0.45-0.40
AF347015.8-0.45-0.30
AC098691.2-0.45-0.31
AF347015.2-0.44-0.27
AF347015.26-0.43-0.27
MT-CO2-0.42-0.27
MT-ATP8-0.42-0.27

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0019864IgG bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseTAS2139735 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneIEA-
GO:0031225anchored to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140100All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
FERRANDO TAL1 NEIGHBORS 2115All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
MARTINELLI IMMATURE NEUTROPHIL DN 139All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway