SZGR2

Summary ?

GeneID	23060
Symbol	ZNF609
Synonyms	-
Description	zinc finger protein 609
Reference	HGNC:HGNC:29003\|Ensembl:ENSG00000180357\|HPRD:18754\|Vega:OTTHUMG00000172370
Gene type	protein-coding
Map location	15q22.31
Pascal p-value	0.003
Sherlock p-value	0.005
Fetal beta	1.634
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
Expression	Meta-analysis of gene expression	P value: 1.851

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg16639915	15	64960011	ZNF609	2.797E-4	-0.482	0.039	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SIRPA	0.87	0.90
LRRK2	0.87	0.88
SUSD5	0.87	0.87
ZBTB7A	0.85	0.82
MAP3K5	0.85	0.89
TACC1	0.85	0.85
KLF9	0.84	0.87
CBX7	0.84	0.86
KY	0.84	0.83
BCL2L2	0.84	0.81

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TUBB2B	-0.62	-0.61
BCL7C	-0.62	-0.72
KIAA1949	-0.61	-0.53
TRAF4	-0.61	-0.66
RPS19P3	-0.61	-0.79
PPP1R14B	-0.61	-0.72
DYNLT1	-0.60	-0.74
PAFAH1B3	-0.60	-0.60
RPS8	-0.60	-0.75
YBX1	-0.60	-0.59

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP	217	131	All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1	136	76	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	870	876	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	870	876	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-129-5p	222	228	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	222	228	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	3981	3988	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135	440	446	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	440	446	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	721	728	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	3367	3373	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	3367	3373	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	815	821	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	3950	3956	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-19	3980	3986	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	3980	3986	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-205	276	282	m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-214	3618	3624	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-214	3618	3624	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-218	1651	1658	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-219	3570	3577	1A,m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-22	3141	3148	1A,m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-27	782	788	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	782	788	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	3306	3312	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-326	315	322	1A,m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-331	879	885	m8	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-346	136	142	m8	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
miR-378	538	544	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-409-3p	3533	3539	1A	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-450	222	228	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-505	97	103	m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-539	3601	3607	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-539	3601	3607	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-7	3425	3431	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ZNF609