Gene Page: GIF
Summary ?
| GeneID | 2694 |
| Symbol | GIF |
| Synonyms | IF|IFMH|INF|TCN3 |
| Description | gastric intrinsic factor |
| Reference | MIM:609342|HGNC:HGNC:4268|Ensembl:ENSG00000134812|HPRD:02024|Vega:OTTHUMG00000167399 |
| Gene type | protein-coding |
| Map location | 11q13 |
| Pascal p-value | 0.356 |
| Fetal beta | 0.016 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Xu_2012 | Whole Exome Sequencing analysis | De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GIF | chr11 | 59603474 | C | T | NM_005142 | p.294V>I | missense | Schizophrenia | DNM:Xu_2012 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NIPA2 | 0.69 | 0.66 |
| C18orf19 | 0.69 | 0.69 |
| ETF1 | 0.68 | 0.69 |
| DLAT | 0.68 | 0.67 |
| SYAP1 | 0.68 | 0.68 |
| UBLCP1 | 0.67 | 0.67 |
| UBE3C | 0.67 | 0.68 |
| DNAJC10 | 0.67 | 0.67 |
| C2orf29 | 0.67 | 0.65 |
| ABI1 | 0.67 | 0.65 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.53 | -0.45 |
| MT-CO2 | -0.52 | -0.47 |
| AF347015.8 | -0.51 | -0.45 |
| HIGD1B | -0.50 | -0.45 |
| MT-CYB | -0.50 | -0.44 |
| AF347015.2 | -0.50 | -0.42 |
| AF347015.31 | -0.48 | -0.45 |
| FXYD1 | -0.48 | -0.44 |
| AF347015.33 | -0.48 | -0.42 |
| AF347015.15 | -0.46 | -0.41 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION NEOCORTEX UP | 83 | 66 | All SZGR 2.0 genes in this pathway |
| MCCLUNG COCAIN REWARD 4WK | 75 | 47 | All SZGR 2.0 genes in this pathway |
| LABBE WNT3A TARGETS DN | 97 | 53 | All SZGR 2.0 genes in this pathway |
| LABBE TGFB1 TARGETS UP | 102 | 64 | All SZGR 2.0 genes in this pathway |
| LABBE TARGETS OF TGFB1 AND WNT3A DN | 108 | 68 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |