Gene Page: ANO9
Summary ?
| GeneID | 338440 |
| Symbol | ANO9 |
| Synonyms | PIG5|TMEM16J|TP53I5 |
| Description | anoctamin 9 |
| Reference | HGNC:HGNC:20679|Ensembl:ENSG00000185101|HPRD:18214|Vega:OTTHUMG00000165446 |
| Gene type | protein-coding |
| Map location | 11p15.5 |
| Pascal p-value | 0.327 |
| Fetal beta | -0.085 |
| eGene | Caudate basal ganglia Putamen basal ganglia |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Xu_2012 | Whole Exome Sequencing analysis | De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ANO9 | chr11 | 432043 | C | A | NM_001012302 | p.121R>L | missense | Schizophrenia | DNM:Xu_2012 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs498217 | 11 | 249097 | ANO9 | ENSG00000185101.8 | 1.052E-6 | 0 | 192914 | gtex_brain_putamen_basal |
| rs480059 | 11 | 249253 | ANO9 | ENSG00000185101.8 | 1.052E-6 | 0 | 192758 | gtex_brain_putamen_basal |
| rs508693 | 11 | 250075 | ANO9 | ENSG00000185101.8 | 3.244E-6 | 0 | 191936 | gtex_brain_putamen_basal |
| rs1045502 | 11 | 252818 | ANO9 | ENSG00000185101.8 | 3.149E-8 | 0 | 189193 | gtex_brain_putamen_basal |
| rs1045577 | 11 | 252942 | ANO9 | ENSG00000185101.8 | 3.149E-8 | 0 | 189069 | gtex_brain_putamen_basal |
| rs2686878 | 11 | 253958 | ANO9 | ENSG00000185101.8 | 1.947E-8 | 0 | 188053 | gtex_brain_putamen_basal |
| rs143265326 | 11 | 256110 | ANO9 | ENSG00000185101.8 | 2.826E-7 | 0 | 185901 | gtex_brain_putamen_basal |
| rs523899 | 11 | 256255 | ANO9 | ENSG00000185101.8 | 5.021E-8 | 0 | 185756 | gtex_brain_putamen_basal |
| rs532483 | 11 | 257030 | ANO9 | ENSG00000185101.8 | 3.149E-8 | 0 | 184981 | gtex_brain_putamen_basal |
| rs939924 | 11 | 257308 | ANO9 | ENSG00000185101.8 | 2.581E-7 | 0 | 184703 | gtex_brain_putamen_basal |
| rs2734242 | 11 | 258646 | ANO9 | ENSG00000185101.8 | 3.149E-8 | 0 | 183365 | gtex_brain_putamen_basal |
| rs200015280 | 11 | 258741 | ANO9 | ENSG00000185101.8 | 3.149E-8 | 0 | 183270 | gtex_brain_putamen_basal |
| rs2686876 | 11 | 258909 | ANO9 | ENSG00000185101.8 | 2.009E-8 | 0 | 183102 | gtex_brain_putamen_basal |
| rs151035694 | 11 | 262106 | ANO9 | ENSG00000185101.8 | 2.009E-8 | 0 | 179905 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SANA TNF SIGNALING UP | 83 | 56 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |