Gene Page: PPP1R14D
Summary ?
| GeneID | 54866 |
| Symbol | PPP1R14D |
| Synonyms | CPI17-like|GBPI-1|GBPI1 |
| Description | protein phosphatase 1 regulatory inhibitor subunit 14D |
| Reference | MIM:613256|HGNC:HGNC:14953|Ensembl:ENSG00000166143|HPRD:17891|Vega:OTTHUMG00000130064 |
| Gene type | protein-coding |
| Map location | 15q15.1 |
| Pascal p-value | 0.229 |
| Fetal beta | -0.076 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Xu_2012 | Whole Exome Sequencing analysis | De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PPP1R14D | chr15 | 41107855 | C | T | NM_001130143 NM_017726 | p.198G>D . | missense 3-UTR | Schizophrenia | DNM:Xu_2012 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KANK1 | 0.82 | 0.79 |
| CGNL1 | 0.81 | 0.85 |
| SASH1 | 0.81 | 0.83 |
| TNS1 | 0.80 | 0.88 |
| FYCO1 | 0.79 | 0.85 |
| TJP2 | 0.79 | 0.82 |
| TLN1 | 0.78 | 0.82 |
| SSFA2 | 0.78 | 0.79 |
| TJP1 | 0.78 | 0.80 |
| PRELP | 0.76 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF32 | -0.56 | -0.71 |
| SCNM1 | -0.56 | -0.67 |
| MED19 | -0.55 | -0.61 |
| COMMD3 | -0.54 | -0.66 |
| DCTN3 | -0.53 | -0.60 |
| C18orf21 | -0.52 | -0.62 |
| NR2C2AP | -0.52 | -0.60 |
| POLB | -0.51 | -0.62 |
| C12orf73 | -0.51 | -0.58 |
| ALKBH2 | -0.51 | -0.61 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| LIU TARGETS OF VMYB VS CMYB UP | 20 | 12 | All SZGR 2.0 genes in this pathway |
| XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS DN | 211 | 119 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |