Gene Page: FAM47E
Summary ?
| GeneID | 100129583 |
| Symbol | FAM47E |
| Synonyms | - |
| Description | family with sequence similarity 47 member E |
| Reference | HGNC:HGNC:34343|Ensembl:ENSG00000189157|Vega:OTTHUMG00000185390 |
| Gene type | protein-coding |
| Map location | 4q21.1 |
| Pascal p-value | 0.007 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| CV:PheWAS | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
Section I. Genetics and epigenetics annotation
CV:PheWAS
| SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs6812193 | 4 | 77198986 | null | 1.526 | FAM47E | null |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4859642 | 4 | 77164468 | FAM47E | ENSG00000189157.9 | 1.466E-7 | 0 | 29275 | gtex_brain_ba24 |
| rs4859643 | 4 | 77164549 | FAM47E | ENSG00000189157.9 | 1.463E-7 | 0 | 29356 | gtex_brain_ba24 |
| rs6817956 | 4 | 77169394 | FAM47E | ENSG00000189157.9 | 1.003E-7 | 0 | 34201 | gtex_brain_ba24 |
| rs7655112 | 4 | 77176524 | FAM47E | ENSG00000189157.9 | 2.111E-10 | 0 | 41331 | gtex_brain_ba24 |
| rs2289514 | 4 | 77177817 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 42624 | gtex_brain_ba24 |
| rs6849069 | 4 | 77179518 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 44325 | gtex_brain_ba24 |
| rs2119731 | 4 | 77180612 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 45419 | gtex_brain_ba24 |
| rs2119732 | 4 | 77180940 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 45747 | gtex_brain_ba24 |
| rs6813980 | 4 | 77181323 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 46130 | gtex_brain_ba24 |
| rs6814195 | 4 | 77181437 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 46244 | gtex_brain_ba24 |
| rs34034456 | 4 | 77181544 | FAM47E | ENSG00000189157.9 | 1.397E-9 | 0 | 46351 | gtex_brain_ba24 |
| rs2869865 | 4 | 77182004 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 46811 | gtex_brain_ba24 |
| rs2869866 | 4 | 77182726 | FAM47E | ENSG00000189157.9 | 5.539E-10 | 0 | 47533 | gtex_brain_ba24 |
| rs7677256 | 4 | 77184395 | FAM47E | ENSG00000189157.9 | 4.05E-9 | 0 | 49202 | gtex_brain_ba24 |
| rs28492993 | 4 | 77186812 | FAM47E | ENSG00000189157.9 | 4.05E-9 | 0 | 51619 | gtex_brain_ba24 |
| rs58804635 | 4 | 77186924 | FAM47E | ENSG00000189157.9 | 1.455E-8 | 0 | 51731 | gtex_brain_ba24 |
| rs56060342 | 4 | 77187032 | FAM47E | ENSG00000189157.9 | 1.455E-8 | 0 | 51839 | gtex_brain_ba24 |
| rs7687964 | 4 | 77187626 | FAM47E | ENSG00000189157.9 | 4.05E-9 | 0 | 52433 | gtex_brain_ba24 |
| rs4859652 | 4 | 77188244 | FAM47E | ENSG00000189157.9 | 4.05E-9 | 0 | 53051 | gtex_brain_ba24 |
| rs4859653 | 4 | 77188613 | FAM47E | ENSG00000189157.9 | 9.186E-9 | 0 | 53420 | gtex_brain_ba24 |
| rs2869872 | 4 | 77191112 | FAM47E | ENSG00000189157.9 | 1.911E-6 | 0 | 55919 | gtex_brain_ba24 |
| rs1441911 | 4 | 77193545 | FAM47E | ENSG00000189157.9 | 1.911E-6 | 0 | 58352 | gtex_brain_ba24 |
| rs1441912 | 4 | 77193728 | FAM47E | ENSG00000189157.9 | 2.162E-6 | 0 | 58535 | gtex_brain_ba24 |
| rs768981 | 4 | 77194473 | FAM47E | ENSG00000189157.9 | 2.027E-7 | 0 | 59280 | gtex_brain_ba24 |
| rs1441916 | 4 | 77201066 | FAM47E | ENSG00000189157.9 | 1.911E-6 | 0 | 65873 | gtex_brain_ba24 |
| rs1036788 | 4 | 77201487 | FAM47E | ENSG00000189157.9 | 1.911E-6 | 0 | 66294 | gtex_brain_ba24 |
| rs1530295 | 4 | 77202762 | FAM47E | ENSG00000189157.9 | 1.911E-6 | 0 | 67569 | gtex_brain_ba24 |
| rs11097313 | 4 | 77185293 | FAM47E | ENSG00000189157.9 | 2.576E-9 | 0 | 50100 | gtex_brain_putamen_basal |
| rs1876536 | 4 | 77185529 | FAM47E | ENSG00000189157.9 | 1.125E-9 | 0 | 50336 | gtex_brain_putamen_basal |
| rs1876537 | 4 | 77185997 | FAM47E | ENSG00000189157.9 | 2.618E-9 | 0 | 50804 | gtex_brain_putamen_basal |
| rs17308336 | 4 | 77186415 | FAM47E | ENSG00000189157.9 | 2.643E-9 | 0 | 51222 | gtex_brain_putamen_basal |
| rs17236158 | 4 | 77186596 | FAM47E | ENSG00000189157.9 | 1.619E-7 | 0 | 51403 | gtex_brain_putamen_basal |
| rs60397621 | 4 | 77186672 | FAM47E | ENSG00000189157.9 | 2.643E-9 | 0 | 51479 | gtex_brain_putamen_basal |
| rs11097314 | 4 | 77187556 | FAM47E | ENSG00000189157.9 | 2.643E-9 | 0 | 52363 | gtex_brain_putamen_basal |
| rs4859650 | 4 | 77188132 | FAM47E | ENSG00000189157.9 | 1.132E-9 | 0 | 52939 | gtex_brain_putamen_basal |
| rs4859651 | 4 | 77188240 | FAM47E | ENSG00000189157.9 | 2.631E-9 | 0 | 53047 | gtex_brain_putamen_basal |
| rs1876538 | 4 | 77189984 | FAM47E | ENSG00000189157.9 | 1.823E-9 | 0 | 54791 | gtex_brain_putamen_basal |
| rs1876539 | 4 | 77190069 | FAM47E | ENSG00000189157.9 | 1.823E-9 | 0 | 54876 | gtex_brain_putamen_basal |
| rs736636 | 4 | 77190221 | FAM47E | ENSG00000189157.9 | 1.822E-9 | 0 | 55028 | gtex_brain_putamen_basal |
| rs736634 | 4 | 77190269 | FAM47E | ENSG00000189157.9 | 1.822E-9 | 0 | 55076 | gtex_brain_putamen_basal |
| rs2869870 | 4 | 77190680 | FAM47E | ENSG00000189157.9 | 7.166E-10 | 0 | 55487 | gtex_brain_putamen_basal |
| rs2869871 | 4 | 77190733 | FAM47E | ENSG00000189157.9 | 1.821E-9 | 0 | 55540 | gtex_brain_putamen_basal |
| rs1876540 | 4 | 77190902 | FAM47E | ENSG00000189157.9 | 1.809E-9 | 0 | 55709 | gtex_brain_putamen_basal |
| rs1876541 | 4 | 77190932 | FAM47E | ENSG00000189157.9 | 9.767E-9 | 0 | 55739 | gtex_brain_putamen_basal |
| rs1876542 | 4 | 77191003 | FAM47E | ENSG00000189157.9 | 1.821E-9 | 0 | 55810 | gtex_brain_putamen_basal |
| rs1876543 | 4 | 77191049 | FAM47E | ENSG00000189157.9 | 1.066E-9 | 0 | 55856 | gtex_brain_putamen_basal |
| rs60876302 | 4 | 77191260 | FAM47E | ENSG00000189157.9 | 1.82E-9 | 0 | 56067 | gtex_brain_putamen_basal |
| rs61595008 | 4 | 77191316 | FAM47E | ENSG00000189157.9 | 1.82E-9 | 0 | 56123 | gtex_brain_putamen_basal |
| rs60768232 | 4 | 77191355 | FAM47E | ENSG00000189157.9 | 1.897E-9 | 0 | 56162 | gtex_brain_putamen_basal |
| rs59864739 | 4 | 77191422 | FAM47E | ENSG00000189157.9 | 1.82E-9 | 0 | 56229 | gtex_brain_putamen_basal |
| rs4859654 | 4 | 77191596 | FAM47E | ENSG00000189157.9 | 6.354E-10 | 0 | 56403 | gtex_brain_putamen_basal |
| rs13119644 | 4 | 77191921 | FAM47E | ENSG00000189157.9 | 1.819E-9 | 0 | 56728 | gtex_brain_putamen_basal |
| rs13151765 | 4 | 77192063 | FAM47E | ENSG00000189157.9 | 1.818E-9 | 0 | 56870 | gtex_brain_putamen_basal |
| rs3821980 | 4 | 77192388 | FAM47E | ENSG00000189157.9 | 1.818E-9 | 0 | 57195 | gtex_brain_putamen_basal |
| rs3733253 | 4 | 77192688 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 57495 | gtex_brain_putamen_basal |
| rs3733250 | 4 | 77192868 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 57675 | gtex_brain_putamen_basal |
| rs1441909 | 4 | 77193136 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 57943 | gtex_brain_putamen_basal |
| rs1441910 | 4 | 77193449 | FAM47E | ENSG00000189157.9 | 8.235E-9 | 0 | 58256 | gtex_brain_putamen_basal |
| rs1441913 | 4 | 77193742 | FAM47E | ENSG00000189157.9 | 1.736E-9 | 0 | 58549 | gtex_brain_putamen_basal |
| rs12643334 | 4 | 77194092 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 58899 | gtex_brain_putamen_basal |
| rs768979 | 4 | 77194246 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 59053 | gtex_brain_putamen_basal |
| rs4859655 | 4 | 77194664 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 59471 | gtex_brain_putamen_basal |
| rs4859438 | 4 | 77194670 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 59477 | gtex_brain_putamen_basal |
| rs4859656 | 4 | 77194684 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 59491 | gtex_brain_putamen_basal |
| rs4859657 | 4 | 77194881 | FAM47E | ENSG00000189157.9 | 6.61E-10 | 0 | 59688 | gtex_brain_putamen_basal |
| rs4859439 | 4 | 77194997 | FAM47E | ENSG00000189157.9 | 1.85E-9 | 0 | 59804 | gtex_brain_putamen_basal |
| rs1583944 | 4 | 77195318 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 60125 | gtex_brain_putamen_basal |
| rs4859440 | 4 | 77195732 | FAM47E | ENSG00000189157.9 | 1.004E-8 | 0 | 60539 | gtex_brain_putamen_basal |
| rs7665023 | 4 | 77196034 | FAM47E | ENSG00000189157.9 | 1.817E-9 | 0 | 60841 | gtex_brain_putamen_basal |
| rs1441914 | 4 | 77196500 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 61307 | gtex_brain_putamen_basal |
| rs6823078 | 4 | 77196848 | FAM47E | ENSG00000189157.9 | 1.814E-9 | 0 | 61655 | gtex_brain_putamen_basal |
| rs1837870 | 4 | 77197223 | FAM47E | ENSG00000189157.9 | 3.24E-10 | 0 | 62030 | gtex_brain_putamen_basal |
| rs80038453 | 4 | 77197741 | FAM47E | ENSG00000189157.9 | 9.064E-9 | 0 | 62548 | gtex_brain_putamen_basal |
| rs13123108 | 4 | 77197882 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 62689 | gtex_brain_putamen_basal |
| rs7699714 | 4 | 77198571 | FAM47E | ENSG00000189157.9 | 1.621E-9 | 0 | 63378 | gtex_brain_putamen_basal |
| rs11934863 | 4 | 77198791 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 63598 | gtex_brain_putamen_basal |
| rs964051 | 4 | 77199414 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 64221 | gtex_brain_putamen_basal |
| rs4859441 | 4 | 77199941 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 64748 | gtex_brain_putamen_basal |
| rs11946804 | 4 | 77200799 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 65606 | gtex_brain_putamen_basal |
| rs11946806 | 4 | 77200805 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 65612 | gtex_brain_putamen_basal |
| rs11933305 | 4 | 77200875 | FAM47E | ENSG00000189157.9 | 6.341E-10 | 0 | 65682 | gtex_brain_putamen_basal |
| rs1530296 | 4 | 77202812 | FAM47E | ENSG00000189157.9 | 2.597E-9 | 0 | 67619 | gtex_brain_putamen_basal |
| rs1530297 | 4 | 77202861 | FAM47E | ENSG00000189157.9 | 7.932E-10 | 0 | 67668 | gtex_brain_putamen_basal |
| rs1530298 | 4 | 77202882 | FAM47E | ENSG00000189157.9 | 2.641E-9 | 0 | 67689 | gtex_brain_putamen_basal |
| rs1969149 | 4 | 77203043 | FAM47E | ENSG00000189157.9 | 2.744E-9 | 0 | 67850 | gtex_brain_putamen_basal |
| rs1969148 | 4 | 77203413 | FAM47E | ENSG00000189157.9 | 1.82E-9 | 0 | 68220 | gtex_brain_putamen_basal |
| rs76951984 | 4 | 77203855 | FAM47E | ENSG00000189157.9 | 5.562E-10 | 0 | 68662 | gtex_brain_putamen_basal |
| rs5859507 | 4 | 77203859 | FAM47E | ENSG00000189157.9 | 8.265E-10 | 0 | 68666 | gtex_brain_putamen_basal |
| rs1508335 | 4 | 77218240 | FAM47E | ENSG00000189157.9 | 1.218E-6 | 0 | 83047 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.