Gene Page: HCN4
Summary ?
| GeneID | 10021 |
| Symbol | HCN4 |
| Synonyms | SSS2 |
| Description | hyperpolarization activated cyclic nucleotide gated potassium channel 4 |
| Reference | MIM:605206|HGNC:HGNC:16882|Ensembl:ENSG00000138622|HPRD:09240|Vega:OTTHUMG00000137563 |
| Gene type | protein-coding |
| Map location | 15q24.1 |
| Pascal p-value | 0.003 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MMP24 | 0.89 | 0.90 |
| C11orf63 | 0.88 | 0.88 |
| GNE | 0.88 | 0.88 |
| PHF13 | 0.88 | 0.86 |
| FARP1 | 0.87 | 0.85 |
| SLC37A1 | 0.87 | 0.88 |
| DPYSL3 | 0.87 | 0.85 |
| PABPC4 | 0.86 | 0.86 |
| EIF4G2 | 0.86 | 0.89 |
| JARID2 | 0.86 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.72 | -0.83 |
| AF347015.27 | -0.72 | -0.82 |
| MT-CO2 | -0.71 | -0.83 |
| AF347015.33 | -0.70 | -0.80 |
| MT-CYB | -0.69 | -0.81 |
| AF347015.8 | -0.69 | -0.83 |
| HLA-F | -0.68 | -0.71 |
| AF347015.15 | -0.67 | -0.81 |
| C5orf53 | -0.67 | -0.69 |
| FXYD1 | -0.66 | -0.77 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME POTASSIUM CHANNELS | 98 | 68 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING VIA SMAD4 UP | 108 | 66 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 | 142 | 103 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |