Gene Page: CDH7
Summary ?
| GeneID | 1005 |
| Symbol | CDH7 |
| Synonyms | CDH7L1 |
| Description | cadherin 7 |
| Reference | MIM:605806|HGNC:HGNC:1766|Ensembl:ENSG00000081138|HPRD:12049|Vega:OTTHUMG00000132800 |
| Gene type | protein-coding |
| Map location | 18q22.1 |
| Pascal p-value | 0.082 |
| Fetal beta | -1.913 |
| eGene | Myers' cis & trans Meta |
| Support | CELL ADHESION AND TRANSSYNAPTIC SIGNALING |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | CDH7 | 1005 | 4.312E-4 | trans | ||
| rs16955618 | chr15 | 29937543 | CDH7 | 1005 | 0.01 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FRMPD4 | 0.76 | 0.81 |
| PCDHA5 | 0.76 | 0.78 |
| RIMBP2 | 0.75 | 0.79 |
| DLG3 | 0.75 | 0.75 |
| LMTK2 | 0.74 | 0.75 |
| ARHGEF3 | 0.74 | 0.77 |
| INPP4A | 0.74 | 0.76 |
| LINGO2 | 0.73 | 0.74 |
| EPHA4 | 0.73 | 0.80 |
| DLG2 | 0.73 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AP002478.3 | -0.49 | -0.55 |
| FXYD1 | -0.47 | -0.46 |
| ACSF2 | -0.47 | -0.52 |
| AL139819.3 | -0.47 | -0.49 |
| AC021016.1 | -0.46 | -0.48 |
| AF347015.21 | -0.46 | -0.48 |
| TLCD1 | -0.46 | -0.46 |
| C11orf67 | -0.45 | -0.52 |
| AF347015.33 | -0.45 | -0.45 |
| MT-CO2 | -0.45 | -0.49 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
| REACTOME ADHERENS JUNCTIONS INTERACTIONS | 27 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 56 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL JUNCTION ORGANIZATION | 78 | 43 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K27ME3 | 70 | 35 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |