Summary ?
GeneID10069
SymbolRWDD2B
SynonymsC21orf6|GL011
DescriptionRWD domain containing 2B
ReferenceHGNC:HGNC:1302|Ensembl:ENSG00000156253|HPRD:10757|Vega:OTTHUMG00000078805
Gene typeprotein-coding
Map location21q22.11
Pascal p-value0.029
Sherlock p-value0.013
Fetal beta-1.479
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg202202422130392188RWDD2B1.071E-40.7080.028DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2832207chr2130505339RWDD2B100690.18cis
rs3759607042130249462RWDD2BENSG00000156253.21.49E-70142237gtex_brain_ba24
rs27056672130314085RWDD2BENSG00000156253.21.842E-7077614gtex_brain_ba24
rs581028672130327732RWDD2BENSG00000156253.21.195E-6063967gtex_brain_ba24
rs1999919522130327734RWDD2BENSG00000156253.26.85E-7063965gtex_brain_ba24
rs22478092130330451RWDD2BENSG00000156253.22.456E-12061248gtex_brain_ba24
rs341911592130339120RWDD2BENSG00000156253.28.429E-7052579gtex_brain_ba24
rs27762462130341497RWDD2BENSG00000156253.21.57E-8050202gtex_brain_ba24
rs27056582130360379RWDD2BENSG00000156253.22.483E-10031320gtex_brain_ba24
rs19678692130367866RWDD2BENSG00000156253.21.069E-6023833gtex_brain_ba24
rs19700522130373541RWDD2BENSG00000156253.21.916E-10018158gtex_brain_ba24
rs21504032130376145RWDD2BENSG00000156253.22.393E-12015554gtex_brain_ba24
rs3863945522130378191RWDD2BENSG00000156253.21.039E-12013508gtex_brain_ba24
rs99801922130386936RWDD2BENSG00000156253.22.393E-1204763gtex_brain_ba24
rs72800432130388553RWDD2BENSG00000156253.22.393E-1203146gtex_brain_ba24
rs72757472130389622RWDD2BENSG00000156253.22.393E-1202077gtex_brain_ba24
rs108543212130390157RWDD2BENSG00000156253.22.393E-1201542gtex_brain_ba24
rs8787972130391309RWDD2BENSG00000156253.21.429E-120390gtex_brain_ba24
rs99823322130392826RWDD2BENSG00000156253.22.393E-120-1127gtex_brain_ba24
rs65168862130393664RWDD2BENSG00000156253.22.393E-120-1965gtex_brain_ba24
rs130467942130394099RWDD2BENSG00000156253.22.461E-100-2400gtex_brain_ba24
rs343386442130399156RWDD2BENSG00000156253.22.461E-100-7457gtex_brain_ba24
rs81337682130400110RWDD2BENSG00000156253.22.393E-120-8411gtex_brain_ba24
rs28321532130409057RWDD2BENSG00000156253.22.461E-100-17358gtex_brain_ba24
rs353582302130410198RWDD2BENSG00000156253.22.454E-100-18499gtex_brain_ba24
rs28321552130410350RWDD2BENSG00000156253.22.393E-120-18651gtex_brain_ba24
rs22435212130431730RWDD2BENSG00000156253.23.972E-80-40031gtex_brain_ba24
rs10640192130432145RWDD2BENSG00000156253.24.836E-100-40446gtex_brain_ba24
rs21835692130442475RWDD2BENSG00000156253.27.984E-70-50776gtex_brain_ba24
rs28538352130443809RWDD2BENSG00000156253.21.54E-90-52110gtex_brain_ba24
rs20706132130445268RWDD2BENSG00000156253.27.963E-70-53569gtex_brain_ba24
rs28538322130448797RWDD2BENSG00000156253.21.032E-100-57098gtex_brain_ba24
rs28538312130449424RWDD2BENSG00000156253.23.62E-80-57725gtex_brain_ba24
rs124824292130453746RWDD2BENSG00000156253.24.95E-90-62047gtex_brain_ba24
rs99782812130454204RWDD2BENSG00000156253.28.575E-70-62505gtex_brain_ba24
rs18884382130454416RWDD2BENSG00000156253.25.003E-90-62717gtex_brain_ba24
rs354264832130455632RWDD2BENSG00000156253.23.354E-80-63933gtex_brain_ba24
rs81281702130456535RWDD2BENSG00000156253.28.728E-70-64836gtex_brain_ba24
rs28321622130461808RWDD2BENSG00000156253.28.079E-70-70109gtex_brain_ba24
rs15716802130470087RWDD2BENSG00000156253.23.511E-80-78388gtex_brain_ba24
rs113280422130504612RWDD2BENSG00000156253.24.503E-80-112913gtex_brain_ba24
rs797343262130504925RWDD2BENSG00000156253.21.652E-60-113226gtex_brain_ba24
rs28322082130506189RWDD2BENSG00000156253.21.719E-60-114490gtex_brain_ba24
rs726136032130514337RWDD2BENSG00000156253.21.719E-60-122638gtex_brain_ba24
rs1115084112130515879RWDD2BENSG00000156253.21.666E-60-124180gtex_brain_ba24
rs22665162130221627RWDD2BENSG00000156253.23.387E-60170072gtex_brain_putamen_basal
rs27057002130223318RWDD2BENSG00000156253.23.186E-60168381gtex_brain_putamen_basal
rs15549902130243201RWDD2BENSG00000156253.23.5E-60148498gtex_brain_putamen_basal
rs3759607042130249462RWDD2BENSG00000156253.24.465E-80142237gtex_brain_putamen_basal
rs27762132130269162RWDD2BENSG00000156253.27.171E-70122537gtex_brain_putamen_basal
rs27056762130270377RWDD2BENSG00000156253.23.662E-60121322gtex_brain_putamen_basal
rs22451772130270416RWDD2BENSG00000156253.23.653E-60121283gtex_brain_putamen_basal
rs22665622130271636RWDD2BENSG00000156253.23.959E-100120063gtex_brain_putamen_basal
rs672800972130273574RWDD2BENSG00000156253.25.669E-70118125gtex_brain_putamen_basal
rs27762272130274908RWDD2BENSG00000156253.26.81E-70116791gtex_brain_putamen_basal
rs10006852130276449RWDD2BENSG00000156253.25.535E-70115250gtex_brain_putamen_basal
rs21423742130277054RWDD2BENSG00000156253.25.548E-70114645gtex_brain_putamen_basal
rs28321372130280016RWDD2BENSG00000156253.22.369E-60111683gtex_brain_putamen_basal
rs24722092130281420RWDD2BENSG00000156253.21.63E-70110279gtex_brain_putamen_basal
rs27762322130284331RWDD2BENSG00000156253.21.639E-70107368gtex_brain_putamen_basal
rs20262452130287067RWDD2BENSG00000156253.21.527E-70104632gtex_brain_putamen_basal
rs22562802130294415RWDD2BENSG00000156253.21.568E-7097284gtex_brain_putamen_basal
rs24646202130298338RWDD2BENSG00000156253.21.579E-7093361gtex_brain_putamen_basal
rs24723182130298894RWDD2BENSG00000156253.26.962E-7092805gtex_brain_putamen_basal
rs725519172130305530RWDD2BENSG00000156253.23.618E-7086169gtex_brain_putamen_basal
rs27056522130306159RWDD2BENSG00000156253.22.116E-6085540gtex_brain_putamen_basal
rs65168812130308132RWDD2BENSG00000156253.28.585E-9083567gtex_brain_putamen_basal
rs27056672130314085RWDD2BENSG00000156253.29.536E-7077614gtex_brain_putamen_basal
rs22435522130318466RWDD2BENSG00000156253.21.9E-6073233gtex_brain_putamen_basal
rs581028672130327732RWDD2BENSG00000156253.29.623E-8063967gtex_brain_putamen_basal
rs1999919522130327734RWDD2BENSG00000156253.21.791E-6063965gtex_brain_putamen_basal
rs27762422130328474RWDD2BENSG00000156253.27.362E-7063225gtex_brain_putamen_basal
rs22478092130330451RWDD2BENSG00000156253.21.873E-12061248gtex_brain_putamen_basal
rs27762462130341497RWDD2BENSG00000156253.29.809E-11050202gtex_brain_putamen_basal
rs27056582130360379RWDD2BENSG00000156253.21.239E-10031320gtex_brain_putamen_basal
rs19700522130373541RWDD2BENSG00000156253.28.351E-12018158gtex_brain_putamen_basal
rs21504032130376145RWDD2BENSG00000156253.21.734E-12015554gtex_brain_putamen_basal
rs3863945522130378191RWDD2BENSG00000156253.24.782E-12013508gtex_brain_putamen_basal
rs130485012130383527RWDD2BENSG00000156253.22.549E-608172gtex_brain_putamen_basal
rs99801922130386936RWDD2BENSG00000156253.21.734E-1204763gtex_brain_putamen_basal
rs72800432130388553RWDD2BENSG00000156253.21.734E-1203146gtex_brain_putamen_basal
rs72757472130389622RWDD2BENSG00000156253.21.734E-1202077gtex_brain_putamen_basal
rs108543212130390157RWDD2BENSG00000156253.21.734E-1201542gtex_brain_putamen_basal
rs8787972130391309RWDD2BENSG00000156253.21.734E-120390gtex_brain_putamen_basal
rs99823322130392826RWDD2BENSG00000156253.21.734E-120-1127gtex_brain_putamen_basal
rs65168862130393664RWDD2BENSG00000156253.21.734E-120-1965gtex_brain_putamen_basal
rs130467942130394099RWDD2BENSG00000156253.22.794E-110-2400gtex_brain_putamen_basal
rs343386442130399156RWDD2BENSG00000156253.22.794E-110-7457gtex_brain_putamen_basal
rs81337682130400110RWDD2BENSG00000156253.21.734E-120-8411gtex_brain_putamen_basal
rs28321532130409057RWDD2BENSG00000156253.22.794E-110-17358gtex_brain_putamen_basal
rs353582302130410198RWDD2BENSG00000156253.21.464E-100-18499gtex_brain_putamen_basal
rs28321552130410350RWDD2BENSG00000156253.21.734E-120-18651gtex_brain_putamen_basal
rs22435212130431730RWDD2BENSG00000156253.22.686E-70-40031gtex_brain_putamen_basal
rs10640192130432145RWDD2BENSG00000156253.23.87E-100-40446gtex_brain_putamen_basal
rs21835692130442475RWDD2BENSG00000156253.25.196E-70-50776gtex_brain_putamen_basal
rs28538352130443809RWDD2BENSG00000156253.27.269E-110-52110gtex_brain_putamen_basal
rs20706132130445268RWDD2BENSG00000156253.25.196E-70-53569gtex_brain_putamen_basal
rs28538322130448797RWDD2BENSG00000156253.21.814E-110-57098gtex_brain_putamen_basal
rs28538312130449424RWDD2BENSG00000156253.21.359E-70-57725gtex_brain_putamen_basal
rs99776962130453645RWDD2BENSG00000156253.23.444E-60-61946gtex_brain_putamen_basal
rs124824292130453746RWDD2BENSG00000156253.28.11E-110-62047gtex_brain_putamen_basal
rs99782812130454204RWDD2BENSG00000156253.25.196E-70-62505gtex_brain_putamen_basal
rs18884382130454416RWDD2BENSG00000156253.28.11E-110-62717gtex_brain_putamen_basal
rs106096152130455628RWDD2BENSG00000156253.23.752E-80-63929gtex_brain_putamen_basal
rs354264832130455632RWDD2BENSG00000156253.23.112E-100-63933gtex_brain_putamen_basal
rs81281702130456535RWDD2BENSG00000156253.25.196E-70-64836gtex_brain_putamen_basal
rs72839302130461373RWDD2BENSG00000156253.21.372E-60-69674gtex_brain_putamen_basal
rs15716802130470087RWDD2BENSG00000156253.21.167E-70-78388gtex_brain_putamen_basal
rs48172712130491939RWDD2BENSG00000156253.21.601E-100-100240gtex_brain_putamen_basal
rs48172722130491944RWDD2BENSG00000156253.21.601E-100-100245gtex_brain_putamen_basal
rs558245772130492718RWDD2BENSG00000156253.27.235E-80-101019gtex_brain_putamen_basal
rs680469202130492837RWDD2BENSG00000156253.27.235E-80-101138gtex_brain_putamen_basal
rs28321952130497238RWDD2BENSG00000156253.21.601E-100-105539gtex_brain_putamen_basal
rs28322052130504215RWDD2BENSG00000156253.27.235E-80-112516gtex_brain_putamen_basal
rs48163392130504421RWDD2BENSG00000156253.27.235E-80-112722gtex_brain_putamen_basal
rs113280422130504612RWDD2BENSG00000156253.23.493E-110-112913gtex_brain_putamen_basal
rs72823572130505004RWDD2BENSG00000156253.22.267E-80-113305gtex_brain_putamen_basal
rs28322072130505340RWDD2BENSG00000156253.27.235E-80-113641gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
OLIG10.890.90
SOX100.840.85
ZCCHC240.820.84
SOX80.810.89
NKX2-20.810.86
PRR180.800.81
HEPACAM0.780.80
VWA10.780.81
GM2A0.780.80
B3GNT90.770.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRG1-0.47-0.54
DACT1-0.46-0.38
POLB-0.46-0.51
ZNF124-0.46-0.44
NEUROD6-0.46-0.44
KLHL1-0.45-0.40
STMN1-0.45-0.44
C11orf57-0.45-0.52
ZNF551-0.45-0.40
AC004017.1-0.45-0.39

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY UP 4129All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
ZWANG EGF PERSISTENTLY DN 6136All SZGR 2.0 genes in this pathway