Summary ?
GeneID10089
SymbolKCNK7
SynonymsK2p7.1|TWIK3
Descriptionpotassium two pore domain channel subfamily K member 7
ReferenceMIM:603940|HGNC:HGNC:6282|Ensembl:ENSG00000173338|HPRD:06804|Vega:OTTHUMG00000166528
Gene typeprotein-coding
Map location11q13
Pascal p-value0.001

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MPPE10.780.83
ACE0.700.69
CHST20.680.77
BEST40.680.75
ACHE0.680.74
EPCAM0.660.68
LRRTM10.660.75
F120.650.69
SLC1A60.650.74
MMP170.640.74
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.2-0.42-0.53
AF347015.31-0.41-0.50
AF347015.8-0.39-0.50
AF347015.33-0.39-0.49
COPZ2-0.39-0.50
AF347015.27-0.39-0.49
MT-CO2-0.39-0.47
AF347015.15-0.38-0.47
MT-CYB-0.37-0.47
ALDH1A1-0.37-0.45

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS 127All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS 9868All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 16280All SZGR 2.0 genes in this pathway
SENGUPTA EBNA1 ANTICORRELATED 17385All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway