Gene Page: TRIM28

Summary ?
GeneID10155
SymbolTRIM28
SynonymsKAP1|PPP1R157|RNF96|TF1B|TIF1B
Descriptiontripartite motif containing 28
ReferenceMIM:601742|HGNC:HGNC:16384|Ensembl:ENSG00000130726|HPRD:03445|Vega:OTTHUMG00000183546
Gene typeprotein-coding
Map location19q13.4
Pascal p-value0.004
Sherlock p-value0.652
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs3845734chr2171125572TRIM28101550.09trans
rs7787830chr798797019TRIM28101550.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBX1CBX | HP1-BETA | HP1Hs-beta | HP1Hsbeta | M31 | MOD1 | p25betachromobox homolog 1 (HP1 beta homolog Drosophila )-HPRD,BioGRID10562550 |11336697 
CBX3HECH | HP1-GAMMA | HP1Hs-gammachromobox homolog 3 (HP1 gamma homolog, Drosophila)Affinity Capture-Western
in vitro
in vivo		BioGRID10562550 |11336697 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID10562550 |10938122 
|11336697 |12154074 
|12411497 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)-HPRD10562550 |12154074 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID9742105 |11711437 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3Two-hybridBioGRID16169070 
HLA-BAS | HLA-B-7301 | HLA-B73 | HLAB | HLAC | SPDA1major histocompatibility complex, class I, BAffinity Capture-MSBioGRID17353931 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Co-purificationBioGRID11013263 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID9742105 
SERTAD2MGC126688 | MGC126690 | Sei-2 | TRIP-Br2SERTA domain containing 2-HPRD11331592 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1-HPRD,BioGRID11959841 
SPG7CAR | CMAR | FLJ37308 | MGC126331 | MGC126332 | PGN | SPG5Cspastic paraplegia 7 (pure and complicated autosomal recessive)Two-hybridBioGRID16169070 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
TNFRSF10DCD264 | DCR2 | TRAILR4 | TRUNDDtumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domainAffinity Capture-MSBioGRID17353931 
TRIM23ARD1 | ARFD1 | RNF46tripartite motif-containing 23Co-purificationBioGRID11331580 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24-HPRD,BioGRID12684500 
TRIM28FLJ29029 | KAP1 | RNF96 | TF1B | TIF1Btripartite motif-containing 28-HPRD,BioGRID12684500 
TRIM6RNF89tripartite motif-containing 6Co-purificationBioGRID11331580 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorReconstituted ComplexBioGRID12682018 
VIMFLJ36605vimentinTwo-hybridBioGRID16169070 
ZNF10KOX1zinc finger protein 10-HPRD,BioGRID9016654 |10748030 
ZNF197D3S1363E | P18 | VHLaK | ZKSCAN9 | ZNF166 | ZNF20zinc finger protein 197-HPRD,BioGRID12682018 
ZNF382FLJ14686 | KS1zinc finger protein 382-HPRD11154279 
ZNF74Cos52 | ZNF520 | Zfp520zinc finger protein 74-HPRD,BioGRID12684500 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 3425All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 8461All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 14686All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 11671All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION DN 12267All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE DN 5135All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 10075All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 11069All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 12986All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP 7848All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN 6045All SZGR 2.0 genes in this pathway
NADELLA PRKAR1A TARGETS UP 95All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER DN 11683All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE 4533All SZGR 2.0 genes in this pathway