SZGR2

Summary ?

GeneID	1022
Symbol	CDK7
Synonyms	CAK1\|CDKN7\|HCAK\|MO15\|STK1\|p39MO15
Description	cyclin-dependent kinase 7
Reference	MIM:601955\|HGNC:HGNC:1778\|Ensembl:ENSG00000134058\|HPRD:15993\|Vega:OTTHUMG00000099358
Gene type	protein-coding
Map location	5q12.1
Pascal p-value	0.844
Sherlock p-value	0.011
Fetal beta	0.48

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BOK	0.80	0.82
SLC26A11	0.75	0.70
VAT1	0.74	0.67
RGS19	0.73	0.58
EPS8L1	0.71	0.41
RAC3	0.71	0.52
MVK	0.71	0.73
PIP5KL1	0.69	0.51
NAGLU	0.69	0.70
RNF220	0.68	0.57

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.45	-0.57
MT-CO2	-0.44	-0.57
AF347015.8	-0.42	-0.56
AF347015.21	-0.42	-0.60
MT-CYB	-0.41	-0.55
CXCL14	-0.41	-0.53
AF347015.27	-0.41	-0.53
CARD16	-0.40	-0.58
AF347015.33	-0.40	-0.51
EAF2	-0.40	-0.51

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004693	cyclin-dependent protein kinase activity	TAS	neuron (GO term level: 8)	8208544
GO:0000166	nucleotide binding	IEA		-
GO:0003713	transcription coactivator activity	NAS		15572661
GO:0005524	ATP binding	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0008353	RNA polymerase subunit kinase activity	IEA		-
GO:0008022	protein C-terminus binding	IPI		10801852
GO:0050681	androgen receptor binding	NAS		15572661
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS		7533895
GO:0000718	nucleotide-excision repair, DNA damage removal	EXP		10583946
GO:0006367	transcription initiation from RNA polymerase II promoter	EXP		8946909
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS		7533895
GO:0006368	RNA elongation from RNA polymerase II promoter	EXP		9405375
GO:0006350	transcription	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0006281	DNA repair	IEA		-
GO:0007049	cell cycle	IEA		-
GO:0008283	cell proliferation	TAS		7533895
GO:0051301	cell division	IEA		-
GO:0030521	androgen receptor signaling pathway	NAS		15572661
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA		8692841
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IDA		16109376
GO:0005654	nucleoplasm	EXP		1939271 \|2449431 \|7629134 \|7799941 \|8946909 \|9512541 \|9582279 \|9790902 \|10214908 \|11313499 \|12393749 \|12646563

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western Reconstituted Complex	BioGRID	10734072
CCNH	CAK \| p34 \| p37	cyclin H	Affinity Capture-MS Affinity Capture-Western Two-hybrid	BioGRID	8078587
CCNH	CAK \| p34 \| p37	cyclin H	-	HPRD	9056480
CDK2	p33(CDK2)	cyclin-dependent kinase 2	CDK7 phosphorylates an unspecified isoform of CDK2.	BIND	7629134
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	CAK phosphorylates CDK6. This interaction was modeled on a demonstrated interaction between human CAK and CDK6 from an unspecified species.	BIND	7629134
CUX1	CASP \| CDP \| CDP/Cut \| CDP1 \| COY1 \| CUTL1 \| CUX \| Clox \| Cux/CDP \| GOLIM6 \| Nbla10317 \| p100 \| p110 \| p200 \| p75	cut-like homeobox 1	Reconstituted Complex	BioGRID	11584018
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	Affinity Capture-Western	BioGRID	10428966
ERCC2	COFS2 \| EM9 \| MGC102762 \| MGC126218 \| MGC126219 \| TTD \| XPD	excision repair cross-complementing rodent repair deficiency, complementation group 2	-	HPRD	11445587
ERCC3	BTF2 \| GTF2H \| RAD25 \| TFIIH \| XPB	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	-	HPRD,BioGRID	9130708
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Biochemical Activity	BioGRID	10949034
GTF2H1	BTF2 \| TFB1 \| TFIIH	general transcription factor IIH, polypeptide 1, 62kDa	-	HPRD,BioGRID	9130708
GTF2H2	BTF2 \| BTF2P44 \| MGC102806 \| T-BTF2P44 \| TFIIH	general transcription factor IIH, polypeptide 2, 44kDa	-	HPRD	9130708
GTF2H5	C6orf175 \| TFB5 \| TGF2H5 \| TTD \| TTD-A \| TTDA \| bA120J8.2	general transcription factor IIH, polypeptide 5	-	HPRD,BioGRID	11062469 \|15220921
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Affinity Capture-Western	BioGRID	12527756
HNRNPU	HNRPU \| SAF-A \| U21.1	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	Affinity Capture-Western	BioGRID	10490622
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	-	HPRD,BioGRID	11056214
MED21	SRB7 \| SURB7	mediator complex subunit 21	Affinity Capture-Western	BioGRID	9315662
MNAT1	MAT1 \| RNF66 \| TFB3	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	-	HPRD,BioGRID	8521393
MNAT1	MAT1 \| RNF66 \| TFB3	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	-	HPRD	9130708
MTA1	-	metastasis associated 1	Affinity Capture-Western	BioGRID	12527756
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	RAR-alpha interacts with hMo15.	BIND	15249124
TCEA1	GTF2S \| SII \| TCEA \| TF2S \| TFIIS	transcription elongation factor A (SII), 1	Reconstituted Complex	BioGRID	9305922
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	TR-alpha interacts with hMo15. This interaction was modeled on a demonstrated interaction between chicken TR-alpha and human hMo15.	BIND	15249124
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Affinity Capture-Western Biochemical Activity	BioGRID	9372954 \|9840937
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	VDR interacts with hMo15.	BIND	15249124

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG NUCLEOTIDE EXCISION REPAIR	44	25	All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA PTC1 PATHWAY	11	6	All SZGR 2.0 genes in this pathway
SA G2 AND M PHASES	8	7	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION TERMINATION	22	12	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION	89	64	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION	105	54	All SZGR 2.0 genes in this pathway
REACTOME MRNA CAPPING	30	11	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	65	40	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER	45	24	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	41	21	All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING	161	86	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR	51	27	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	45	19	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	15	8	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	30	13	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	122	80	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR	112	59	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	61	32	All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER	35	20	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	23	11	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE	125	69	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	34	11	All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE	104	61	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION	25	14	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES DN	145	91	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP	98	58	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN	101	66	All SZGR 2.0 genes in this pathway
SILIGAN TARGETS OF EWS FLI1 FUSION UP	15	12	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS UP	35	25	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP	89	61	All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES	45	34	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D6	37	25	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0	107	72	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP	223	132	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1	148	95	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-496	114	121	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	114	121	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CDK7