SZGR2

Summary ?

GeneID	10241
Symbol	CALCOCO2
Synonyms	NDP52
Description	calcium binding and coiled-coil domain 2
Reference	MIM:604587\|HGNC:HGNC:29912\|Ensembl:ENSG00000136436\|HPRD:06846\|Vega:OTTHUMG00000160505
Gene type	protein-coding
Map location	17q21.32
Pascal p-value	8.427E-4
Sherlock p-value	0.472
eGene	Cerebellar Hemisphere Cerebellum

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AMY2B	0.69	0.66
UGCGL2	0.62	0.57
TTC14	0.62	0.52
CATSPER2	0.61	0.56
AHSA2	0.60	0.49
OVGP1	0.60	0.52
AC015813.1	0.59	0.58
ZNF404	0.59	0.52
AP000769.2	0.58	0.54
AMY2A	0.58	0.48

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SHISA5	-0.40	-0.49
TUFM	-0.40	-0.45
ACTG1	-0.40	-0.40
ACTB	-0.40	-0.42
AC025287.3	-0.39	-0.42
FSCN1	-0.39	-0.40
SFRS2B	-0.39	-0.38
SNX12	-0.39	-0.40
AC008629.2	-0.38	-0.46
HMGA1	-0.38	-0.38

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABLIM1	ABLIM \| DKFZp781D0148 \| FLJ14564 \| KIAA0059 \| LIMAB1 \| LIMATIN \| MGC1224	actin binding LIM protein 1	Two-hybrid	BioGRID	16189514
APEX2	APE2 \| APEXL2 \| XTH2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	Two-hybrid	BioGRID	16189514
C16orf48	DAKV6410 \| DKFZp434A1319	chromosome 16 open reading frame 48	Two-hybrid	BioGRID	16189514
C1orf65	FLJ35728 \| RP11-76K24.1	chromosome 1 open reading frame 65	Two-hybrid	BioGRID	16189514
C20orf195	MGC5356	chromosome 20 open reading frame 195	Two-hybrid	BioGRID	16189514
C9orf86	FLJ10101 \| FLJ13045 \| Parf \| RBEL1 \| bA216L13.9 \| pp8875	chromosome 9 open reading frame 86	Two-hybrid	BioGRID	16189514
CALCOCO2	MGC17318 \| NDP52	calcium binding and coiled-coil domain 2	Two-hybrid	BioGRID	16189514
CCDC33	FLJ23168 \| FLJ32855 \| MGC34145	coiled-coil domain containing 33	Two-hybrid	BioGRID	16189514
CPNE7	MGC34192	copine VII	Two-hybrid	BioGRID	16189514
DAZAP2	KIAA0058 \| MGC14319 \| MGC766 \| PRTB	DAZ associated protein 2	Two-hybrid	BioGRID	16189514
DBNDD2	C20orf35 \| CK1BP \| HSMNP1	dysbindin (dystrobrevin binding protein 1) domain containing 2	Two-hybrid	BioGRID	16189514
DKFZp761E198	PP1030	DKFZp761E198 protein	Two-hybrid	BioGRID	16189514
FAM107A	DRR1 \| FLJ30158 \| FLJ45473 \| TU3A	family with sequence similarity 107, member A	Two-hybrid	BioGRID	16189514
FAM164C	C14orf140 \| FLJ23093	family with sequence similarity 164, member C	Two-hybrid	BioGRID	16189514
FASTK	FAST	Fas-activated serine/threonine kinase	Two-hybrid	BioGRID	16189514
FBF1	Alb \| FBF-1 \| FLJ00103	Fas (TNFRSF6) binding factor 1	Two-hybrid	BioGRID	16189514
FBXL18	FLJ10776 \| FLJ11467 \| FLJ26934 \| FLJ38075 \| FLJ41541 \| Fbl18	F-box and leucine-rich repeat protein 18	Two-hybrid	BioGRID	16189514
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
GABARAPL1	APG8-LIKE \| APG8L \| ATG8 \| ATG8L \| GEC1	GABA(A) receptor-associated protein like 1	Two-hybrid	BioGRID	16189514
GABARAPL2	ATG8 \| GATE-16 \| GATE16 \| GEF-2 \| GEF2	GABA(A) receptor-associated protein-like 2	Two-hybrid	BioGRID	16189514
GEMIN4	DKFZp434B131 \| DKFZp434D174 \| HC56 \| HCAP1 \| HHRF-1 \| p97	gem (nuclear organelle) associated protein 4	HCAP1 interacts with NDP52	BIND	12869526
KIAA1267	DKFZp686P06109 \| DKFZp727C091 \| MGC102843	KIAA1267	Two-hybrid	BioGRID	16189514
LGALS8	Gal-8 \| PCTA-1 \| PCTA1 \| Po66-CBP	lectin, galactoside-binding, soluble, 8	Two-hybrid	BioGRID	16189514
LNX1	LNX \| MPDZ \| PDZRN2	ligand of numb-protein X 1	Two-hybrid	BioGRID	16189514
LSM4	YER112W	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	Two-hybrid	BioGRID	16189514
MCM10	CNA43 \| DNA43 \| MGC126776 \| PRO2249	minichromosome maintenance complex component 10	Two-hybrid	BioGRID	16189514
MYST2	HBO1 \| HBOA \| KAT7	MYST histone acetyltransferase 2	Two-hybrid	BioGRID	16189514
PCGF1	2010002K04Rik \| FLJ43754 \| MGC10882 \| NSPC1 \| RNF3A-2 \| RNF68	polycomb group ring finger 1	Two-hybrid	BioGRID	16189514
PIAS4	FLJ12419 \| MGC35296 \| PIASY \| Piasg \| ZMIZ6	protein inhibitor of activated STAT, 4	Two-hybrid	BioGRID	16189514
POLI	RAD30B \| RAD3OB	polymerase (DNA directed) iota	Two-hybrid	BioGRID	16189514
PSMA1	HC2 \| MGC14542 \| MGC14575 \| MGC14751 \| MGC1667 \| MGC21459 \| MGC22853 \| MGC23915 \| NU \| PROS30	proteasome (prosome, macropain) subunit, alpha type, 1	Two-hybrid	BioGRID	16189514
PTBP1	HNRNP-I \| HNRNPI \| HNRPI \| MGC10830 \| MGC8461 \| PTB \| PTB-1 \| PTB-T \| PTB2 \| PTB3 \| PTB4 \| pPTB	polypyrimidine tract binding protein 1	Two-hybrid	BioGRID	16189514
PTBP2	FLJ34897 \| PTB \| PTBLP \| brPTB \| nPTB \| nPTB5 \| nPTB6 \| nPTB7 \| nPTB8	polypyrimidine tract binding protein 2	Two-hybrid	BioGRID	16189514
RHPN1	KIAA1929 \| ODF5 \| RHOPHILIN \| RHPN	rhophilin, Rho GTPase binding protein 1	Two-hybrid	BioGRID	16189514
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Two-hybrid	BioGRID	16189514
SMARCD1	BAF60A \| CRACD1 \| Rsc6p	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	Two-hybrid	BioGRID	16189514
SRI	FLJ26259 \| SCN	sorcin	Two-hybrid	BioGRID	16189514
TCEB3B	ELOA2 \| HsT832 \| MGC119351 \| TCEB3L	transcription elongation factor B polypeptide 3B (elongin A2)	Two-hybrid	BioGRID	16189514
TCL1A	TCL1	T-cell leukemia/lymphoma 1A	Two-hybrid	BioGRID	16189514
TP53RK	BUD32 \| C20orf64 \| Nori-2 \| Nori-2p \| PRPK \| dJ101A2	TP53 regulating kinase	Two-hybrid	BioGRID	16189514
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514
VPS72	CFL1 \| Swc2 \| TCFL1 \| YL-1 \| YL1	vacuolar protein sorting 72 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
ZNF101	DKFZp570I0164 \| HZF12 \| MGC149565 \| MGC149566	zinc finger protein 101	Two-hybrid	BioGRID	16189514
ZNF205	ZNF210 \| Zfp13	zinc finger protein 205	Two-hybrid	BioGRID	16189514
ZNF408	FLJ12827	zinc finger protein 408	Two-hybrid	BioGRID	16189514
ZNF426	MGC2663	zinc finger protein 426	Two-hybrid	BioGRID	16189514
ZNF451	COASTER \| FLJ23421 \| FLJ53246 \| FLJ90693 \| KIAA0576 \| KIAA1702 \| MGC26701 \| dJ417I1.1	zinc finger protein 451	Two-hybrid	BioGRID	16189514
ZNF638	DKFZp686P1231 \| MGC26130 \| MGC90196 \| NP220 \| ZFML \| Zfp638	zinc finger protein 638	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN	244	147	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN	47	33	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN	49	29	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP	181	106	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3	718	401	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP	112	65	All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP	266	142	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP	107	72	All SZGR 2.0 genes in this pathway