Gene Page: KATNB1

Summary ?
GeneID10300
SymbolKATNB1
SynonymsKAT|LIS6
Descriptionkatanin p80 (WD repeat containing) subunit B 1
ReferenceMIM:602703|HGNC:HGNC:6217|Ensembl:ENSG00000140854|HPRD:04081|Vega:OTTHUMG00000133467
Gene typeprotein-coding
Map location16q21
Pascal p-value0.327
Sherlock p-value0.286
Fetal beta-0.32

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DNM1L0.840.88
TRAPPC6B0.840.85
YWHAB0.820.84
USP140.820.84
RAB6A0.820.85
NKRF0.820.86
VPS410.820.84
SRPK20.820.86
NDFIP10.820.83
UBE2K0.810.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.2-0.61-0.62
MT-CO2-0.60-0.63
EIF4EBP3-0.60-0.67
FXYD1-0.60-0.62
AF347015.31-0.60-0.62
ACSF2-0.59-0.66
AF347015.8-0.59-0.61
AF347015.21-0.58-0.57
HIGD1B-0.57-0.62
METRN-0.57-0.65

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008568microtubule-severing ATPase activityIDA10751153 
GO:0008017microtubule bindingNAS10751153 
GO:0046982protein heterodimerization activityIPI10751153 
GO:0045502dynein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007026negative regulation of microtubule depolymerizationIMP10751153 
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0006605protein targetingNAS10751153 
GO:0051301cell divisionIEA-
GO:0031117positive regulation of microtubule depolymerizationIMP10751153 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0000922spindle poleIDA10751153 
GO:0005856cytoskeletonIEA-
GO:0005874microtubuleIEA-
GO:0005737cytoplasmIDA10751153 
GO:0008352katanin complexTAS10751153 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349157All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN 8647All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 13582All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
ROYLANCE BREAST CANCER 16Q COPY NUMBER UP 6344All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX DN 2418All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 8152All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 17196All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway