Summary ?
GeneID10313
SymbolRTN3
SynonymsASYIP|HAP|NSPL2|NSPLII|RTN3-A1
Descriptionreticulon 3
ReferenceMIM:604249|HGNC:HGNC:10469|Ensembl:ENSG00000133318|HPRD:18516|Vega:OTTHUMG00000168056
Gene typeprotein-coding
Map location11q13
Pascal p-value0.039
Sherlock p-value0.393
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PLK10.990.83
AURKB0.990.66
KIF2C0.990.72
KIFC10.990.74
UBE2C0.990.67
MYBL20.980.70
CDC200.980.68
GTSE10.980.75
FAM64A0.980.67
NCAPH0.980.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.38-0.59
AF347015.27-0.37-0.71
HLA-F-0.37-0.50
FBXO2-0.36-0.46
AF347015.31-0.36-0.71
PTH1R-0.36-0.44
AF347015.33-0.35-0.66
ABCG2-0.35-0.48
MT-CO2-0.35-0.69
MT-CYB-0.35-0.69

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
COL4A3BPCERT | CERTL | FLJ20597 | GPBP | STARD11collagen, type IV, alpha 3 (Goodpasture antigen) binding proteinTwo-hybridBioGRID16189514 
FAM160A2C11orf56 | DKFZp566M1046 | FLJ22665 | KIAA1759family with sequence similarity 160, member A2Two-hybridBioGRID16189514 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1An unspecified isoform of FGFR1 interacts with RTN3. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RTN3.BIND15117958 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
PLEKHF2FLJ13187 | PHAFIN2 | ZFYVE18pleckstrin homology domain containing, family F (with FYVE domain) member 2Two-hybridBioGRID16189514 
PTPN9MEG2 | PTPMEG2protein tyrosine phosphatase, non-receptor type 9Two-hybridBioGRID16189514 
RAB33AMGC1488 | RabS10RAB33A, member RAS oncogene familyTwo-hybridBioGRID16189514 
RTN3ASYIP | HAP | NSPL2 | NSPLII | RTN3-A1reticulon 3Two-hybridBioGRID16189514 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4Two-hybridBioGRID16189514 
SPOPTEF2speckle-type POZ proteinTwo-hybridBioGRID16189514 
UGCGGCSUDP-glucose ceramide glucosyltransferaseTwo-hybridBioGRID12873973 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 6745All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 8860All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP 3532All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP 6647All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 7455All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315215All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway