Gene Page: RTN3
Summary ?
GeneID | 10313 |
Symbol | RTN3 |
Synonyms | ASYIP|HAP|NSPL2|NSPLII|RTN3-A1 |
Description | reticulon 3 |
Reference | MIM:604249|HGNC:HGNC:10469|Ensembl:ENSG00000133318|HPRD:18516|Vega:OTTHUMG00000168056 |
Gene type | protein-coding |
Map location | 11q13 |
Pascal p-value | 0.039 |
Sherlock p-value | 0.393 |
Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
PLK1 | 0.99 | 0.83 |
AURKB | 0.99 | 0.66 |
KIF2C | 0.99 | 0.72 |
KIFC1 | 0.99 | 0.74 |
UBE2C | 0.99 | 0.67 |
MYBL2 | 0.98 | 0.70 |
CDC20 | 0.98 | 0.68 |
GTSE1 | 0.98 | 0.75 |
FAM64A | 0.98 | 0.67 |
NCAPH | 0.98 | 0.73 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
C5orf53 | -0.38 | -0.59 |
AF347015.27 | -0.37 | -0.71 |
HLA-F | -0.37 | -0.50 |
FBXO2 | -0.36 | -0.46 |
AF347015.31 | -0.36 | -0.71 |
PTH1R | -0.36 | -0.44 |
AF347015.33 | -0.35 | -0.66 |
ABCG2 | -0.35 | -0.48 |
MT-CO2 | -0.35 | -0.69 |
MT-CYB | -0.35 | -0.69 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
COL4A3BP | CERT | CERTL | FLJ20597 | GPBP | STARD11 | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | Two-hybrid | BioGRID | 16189514 |
FAM160A2 | C11orf56 | DKFZp566M1046 | FLJ22665 | KIAA1759 | family with sequence similarity 160, member A2 | Two-hybrid | BioGRID | 16189514 |
FGFR1 | BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAM | fibroblast growth factor receptor 1 | An unspecified isoform of FGFR1 interacts with RTN3. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RTN3. | BIND | 15117958 |
FXR2 | FMR1L2 | fragile X mental retardation, autosomal homolog 2 | Two-hybrid | BioGRID | 16189514 |
PLEKHF2 | FLJ13187 | PHAFIN2 | ZFYVE18 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | Two-hybrid | BioGRID | 16189514 |
PTPN9 | MEG2 | PTPMEG2 | protein tyrosine phosphatase, non-receptor type 9 | Two-hybrid | BioGRID | 16189514 |
RAB33A | MGC1488 | RabS10 | RAB33A, member RAS oncogene family | Two-hybrid | BioGRID | 16189514 |
RTN3 | ASYIP | HAP | NSPL2 | NSPLII | RTN3-A1 | reticulon 3 | Two-hybrid | BioGRID | 16189514 |
RTN4 | ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-C | reticulon 4 | Two-hybrid | BioGRID | 16189514 |
SPOP | TEF2 | speckle-type POZ protein | Two-hybrid | BioGRID | 16189514 |
UGCG | GCS | UDP-glucose ceramide glucosyltransferase | Two-hybrid | BioGRID | 12873973 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
HAHTOLA MYCOSIS FUNGOIDES SKIN UP | 177 | 113 | All SZGR 2.0 genes in this pathway |
ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | All SZGR 2.0 genes in this pathway |
LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | All SZGR 2.0 genes in this pathway |
VANHARANTA UTERINE FIBROID DN | 67 | 45 | All SZGR 2.0 genes in this pathway |
LINDGREN BLADDER CANCER CLUSTER 2B | 392 | 251 | All SZGR 2.0 genes in this pathway |
PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
ALCALA APOPTOSIS | 88 | 60 | All SZGR 2.0 genes in this pathway |
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP | 35 | 32 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP | 66 | 47 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
RAMALHO STEMNESS DN | 74 | 55 | All SZGR 2.0 genes in this pathway |
BURTON ADIPOGENESIS 6 | 189 | 112 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
PASINI SUZ12 TARGETS DN | 315 | 215 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |