Gene Page: MRVI1

Summary ?
GeneID10335
SymbolMRVI1
SynonymsIRAG|JAW1L
Descriptionmurine retrovirus integration site 1 homolog
ReferenceMIM:604673|HGNC:HGNC:7237|Ensembl:ENSG00000072952|HPRD:05242|Vega:OTTHUMG00000165773
Gene typeprotein-coding
Map location11p15
Pascal p-value0.575
Sherlock p-value0.872
Fetal beta-0.588
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10840431chr1110524605MRVI1103354.325E-6cis
rs10770123chr1110534865MRVI1103350.08cis
rs10840433chr1110547173MRVI1103350.16cis
rs1350991chr1110554629MRVI1103350.19cis
rs2054392chr1110558598MRVI1103354.089E-6cis
rs10840444chr1110624214MRVI1103350.12cis
rs964426chr1110632251MRVI1103354.205E-5cis
rs964425chr1110632483MRVI1103351.253E-4cis
rs10840431chr1110524605MRVI1103357.415E-4trans
rs2054392chr1110558598MRVI1103357.061E-4trans
rs964426chr1110632251MRVI1103350.01trans
rs964425chr1110632483MRVI1103350.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SMPD40.940.94
CREBL10.940.93
ZNF3840.940.94
CNOT30.940.93
CIZ10.940.94
DHX160.930.93
PPIL20.930.93
NFRKB0.930.93
DNMT10.920.92
GTF3C20.920.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.77-0.84
AF347015.27-0.75-0.82
MT-CO2-0.75-0.82
AF347015.21-0.72-0.89
MT-CYB-0.72-0.79
AF347015.8-0.72-0.81
AF347015.33-0.71-0.77
IFI27-0.70-0.77
HIGD1B-0.69-0.78
C5orf53-0.68-0.69

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
REACTOME CGMP EFFECTS 1913All SZGR 2.0 genes in this pathway
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 2519All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169118All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
CHEN NEUROBLASTOMA COPY NUMBER GAINS 5035All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 10868All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 13485All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 7252All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP 5438All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway