Gene Page: TRDN
Summary ?
| GeneID | 10345 |
| Symbol | TRDN |
| Synonyms | CPVT5|TDN|TRISK |
| Description | triadin |
| Reference | MIM:603283|HGNC:HGNC:12261|Ensembl:ENSG00000186439|HPRD:04474|Vega:OTTHUMG00000015497 |
| Gene type | protein-coding |
| Map location | 6q22.31 |
| Pascal p-value | 0.007 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17027208 | chr3 | 31219519 | TRDN | 10345 | 0.05 | trans | ||
| rs10994209 | chr10 | 61877705 | TRDN | 10345 | 0.08 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HNRNPU | 0.97 | 0.97 |
| TOP1 | 0.96 | 0.96 |
| SMC3 | 0.96 | 0.96 |
| SUPT16H | 0.96 | 0.96 |
| TARDBP | 0.95 | 0.96 |
| MSH6 | 0.95 | 0.94 |
| PRPF40A | 0.95 | 0.94 |
| STAG1 | 0.95 | 0.96 |
| RSF1 | 0.95 | 0.94 |
| MYEF2 | 0.95 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FXYD1 | -0.71 | -0.88 |
| AF347015.31 | -0.71 | -0.87 |
| IFI27 | -0.71 | -0.87 |
| HLA-F | -0.70 | -0.79 |
| MT-CO2 | -0.70 | -0.88 |
| C5orf53 | -0.69 | -0.74 |
| AF347015.27 | -0.69 | -0.84 |
| AF347015.33 | -0.69 | -0.84 |
| TSC22D4 | -0.68 | -0.80 |
| HIGD1B | -0.67 | -0.86 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | receptor binding | IEA | Neurotransmitter (GO term level: 4) | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006936 | muscle contraction | TAS | 7588753 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IDA | 11026130 | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0016021 | integral to membrane | TAS | 7588753 | |
| GO:0005886 | plasma membrane | IDA | 11026130 | |
| GO:0033017 | sarcoplasmic reticulum membrane | IEA | - | |
| GO:0016529 | sarcoplasmic reticulum | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| THUM SYSTOLIC HEART FAILURE UP | 423 | 283 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM AND NORMAL AGING DN | 225 | 124 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |