Gene Page: NDRG1

Summary
GeneID  10397
Symbol  NDRG1
Synonyms  CAP43|CMT4D|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5
Description  N-myc downstream regulated 1
See related  HGNC:7679|MIM:605262|Ensembl:ENSG00000104419|HPRD:05586|
Locus tag  -
Gene type  protein-coding
Map location  8q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0351 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC38A50.740.68
FCGRT0.710.65
ECSCR0.710.58
FLVCR20.690.54
ELN0.690.55
CTHRC10.680.44
PCOLCE0.660.57
HTRA30.660.45
RAMP20.650.57
FAM124B0.640.47
Top 10 negatively co-expressed genes
TDRD6-0.33-0.39
GPATCH4-0.33-0.39
ANKRD19-0.30-0.29
AC005726.8-0.29-0.37
AC073343.2-0.29-0.33
AMY2B-0.29-0.34
CAPRIN2-0.29-0.34
ABCC5-0.28-0.29
AMY2A-0.28-0.32
AL049829.1-0.28-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17220478 
GO:0031177phosphopantetheine bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0010038response to metal ionTAS9605764 
GO:0045576mast cell activationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIDA18029348 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARL4DARF4L | ARL6ADP-ribosylation factor-like 4DTwo-hybridBioGRID16169070 
PHYHIPDYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1phytanoyl-CoA 2-hydroxylase interacting proteinTwo-hybridBioGRID16169070 
S100BNEF | S100 | S100betaS100 calcium binding protein B-HPRD,BioGRID12493777 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
HOOI_ST7_TARGETS_DN 12378All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_UP 5238All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_UP 13085All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN 9158All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_UP 2921All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_DN 6745All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_UP 11668All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
HWANG_PROSTATE_CANCER_MARKERS 2819All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN 4535All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_DN 10359All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP 1914All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_HELA 6043All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON 15787All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_UP 6140All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_UP 8661All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN 12165All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
MENSE_HYPOXIA_UP 9871All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP 8959All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
LEIN_OLIGODENDROCYTE_MARKERS 7453All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_OLD 1310All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_WS 4026All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_OLD 3119All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_WS 3322All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_WS 129All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP 5641All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_UP 5429All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_UP 5333All SZGR genes in this pathway
PIONTEK_PKD1_TARGETS_UP 3824All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE 128All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION 3021All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE_AND_RARA_PLZF_FUSION 2214All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE 10176All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE 6751All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE 8166All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN 3726All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1 6850All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
DEMAGALHAES_AGING_UP 5539All SZGR genes in this pathway
WANG_ADIPOGENIC_GENES_REPRESSED_BY_SIRT1 2821All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP1 13676All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
FARDIN_HYPOXIA_11 3229All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION 4028All SZGR genes in this pathway
IKEDA_MIR133_TARGETS_UP 4327All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
MALIK_REPRESSED_BY_ESTROGEN 1210All SZGR genes in this pathway
GUILLAUMOND_KLF10_TARGETS_UP 5139All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
BOUDOUKHA_BOUND_BY_IGF2BP2 11159All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_3 1612All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1331952011Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-1822922981Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-34/4492902961Ahsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-9197203m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-962922981Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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