Gene Page: LRRC41

Summary ?
GeneID10489
SymbolLRRC41
SynonymsMUF1|PP7759
Descriptionleucine rich repeat containing 41
ReferenceHGNC:HGNC:16917|Ensembl:ENSG00000132128|HPRD:10102|Vega:OTTHUMG00000007810
Gene typeprotein-coding
Map location1p34.1
Pascal p-value0.928
Sherlock p-value0.976
Fetal beta-0.183
DMG1 (# studies)
SupportCompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg09747578146769076LRRC411.22E-9-0.0151.3E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC005512.10.930.73
AP003108.20.920.44
PTPN70.910.15
PDE1B0.910.77
TMEM90A0.910.54
ADORA2A0.89-0.10
RASD20.890.74
LINGO30.880.75
WNT60.880.64
ANKRD34B0.880.45
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BLVRA-0.25-0.23
STMN1-0.25-0.29
PGBD1-0.24-0.37
KIAA1949-0.24-0.48
TUBB2B-0.24-0.53
ZNF193-0.23-0.50
SH2B2-0.23-0.56
TUBB-0.23-0.28
C19orf57-0.23-0.30
VAV2-0.23-0.43

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
PATTERSON DOCETAXEL RESISTANCE 2920All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 10563All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 4531All SZGR 2.0 genes in this pathway
NUTT GBM VS AO GLIOMA UP 4634All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE GENES 3920All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway