Summary ?
GeneID10524
SymbolKAT5
SynonymsESA1|HTATIP|HTATIP1|PLIP|TIP|TIP60|ZC2HC5|cPLA2
Descriptionlysine acetyltransferase 5
ReferenceMIM:601409|HGNC:HGNC:5275|Ensembl:ENSG00000172977|HPRD:03245|Vega:OTTHUMG00000166617
Gene typeprotein-coding
Map location11q13
Pascal p-value0.006
DEG p-valueDEG:Maycox_2009:CC_BA10_fold_change=-1.05:CC_BA10_disease_P=0.0415:HBB_BA9_fold_change=-1.12:HBB_BA9_disease_P=0.0352
Fetal beta0.164
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DEG:Maycox_2009Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissueWe included 51 genes whose expression changes are common between two schizophrenia cohorts.
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.8537 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
VBP10.890.87
PSMD100.860.86
PSMD140.860.85
FH0.860.84
GTF2B0.850.85
TCEAL80.850.82
YWHAE0.850.85
EAPP0.850.86
DRG10.850.84
MORF4L10.850.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.61-0.57
AF347015.8-0.60-0.56
AF347015.2-0.60-0.60
AF347015.26-0.59-0.59
AF347015.33-0.59-0.57
MT-CYB-0.58-0.56
TINAGL1-0.58-0.62
IFI27-0.57-0.62
USHBP1-0.57-0.62
AF347015.15-0.57-0.57

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0003713transcription coactivator activityNAS15572661 
GO:0005515protein bindingIPI15383276 |16169070 |17110330 
GO:0004402histone acetyltransferase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008415acyltransferase activityIEA-
GO:0046872metal ion bindingIEA-
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthIEA-
GO:0006302double-strand break repairIMP10966108 
GO:0006333chromatin assembly or disassemblyIEA-
GO:0006350transcriptionIEA-
GO:0006366transcription from RNA polymerase II promoterTAS8607265 
GO:0016568chromatin modificationIEA-
GO:0016573histone acetylationIDA10966108 
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045893positive regulation of transcription, DNA-dependentNAS15572661 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinIEA-
GO:0005634nucleusTAS8607265 
GO:0005737cytoplasmIEA-
GO:0035267NuA4 histone acetyltransferase complexIDA10966108 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTL6AACTL6 | Arp4 | BAF53A | INO80K | MGC5382actin-like 6ACo-fractionationBioGRID11839798 
APBB1FE65 | MGC:9072 | RIRamyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)-HPRD12888553 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD12888553 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorBiochemical Activity
Two-hybrid
BioGRID11994312 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD10364196 
ARIH2ARI2 | FLJ10938 | FLJ33921 | TRIAD1ariadne homolog 2 (Drosophila)Two-hybridBioGRID16169070 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3-HPRD,BioGRID10362352 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3HTATIP (Tip60) interacts with BCL3.BIND15829968 
BMI1MGC12685 | PCGF4 | RNF51BMI1 polycomb ring finger oncogeneTwo-hybridBioGRID16169070 
C1orf174RP13-531C17.2chromosome 1 open reading frame 174Two-hybridBioGRID16169070 
C20orf20Eaf7 | FLJ10914 | MRG15BP | MRGBP | URCC4chromosome 20 open reading frame 20-HPRD12963728 
C7orf20CEE | CGI-20chromosome 7 open reading frame 20Two-hybridBioGRID16169070 
CBX8HPC3 | PC3 | RC1chromobox homolog 8 (Pc class homolog, Drosophila)Two-hybridBioGRID16169070 
CCDC106HSU79303 | ZNF581coiled-coil domain containing 106Two-hybridBioGRID16169070 
CCT7CCT-ETA | Ccth | MGC110985 | Nip7-1 | TCP-1-etachaperonin containing TCP1, subunit 7 (eta)Two-hybridBioGRID16169070 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeHTATIP (Tip60) interacts with the CD82 (KAI1) promoter.BIND15829968 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Two-hybridBioGRID16169070 
CDK5RAP2C48 | Cep215 | DKFZp686B1070 | DKFZp686D1070 | KIAA1633 | MCPH3CDK5 regulatory subunit associated protein 2Two-hybridBioGRID16169070 
CREB1CREB | MGC9284cAMP responsive element binding protein 1-HPRD,BioGRID10720489 
CRELD1AVSD2 | CIRRIN | DKFZp566D213cysteine-rich with EGF-like domains 1Two-hybridBioGRID16169070 
CSTF2CstF-64cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDaTwo-hybridBioGRID16169070 
DLEU1BCMS | DLB1 | DLEU2 | LEU1 | LEU2 | MGC22430 | NCRNA00021 | XTP6deleted in lymphocytic leukemia 1 (non-protein coding)Two-hybridBioGRID16169070 
EDNRAETA | ETRAendothelin receptor type AAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11262386 
EFNA1B61 | ECKLG | EFL1 | EPLG1 | LERK1 | TNFAIP4ephrin-A1Two-hybridBioGRID16169070 
EP400CAGH32 | DKFZP434I225 | FLJ42018 | FLJ45115 | P400 | TNRC12E1A binding protein p400Affinity Capture-WesternBioGRID11509179 
ETV6TEL | TEL/ABLets variant 6-HPRD,BioGRID12737628 
FAM101BMGC45871family with sequence similarity 101, member BTwo-hybridBioGRID16169070 
FAM135BC8ORFK32 | MGC126009 | MGC126010 | MGC33221family with sequence similarity 135, member BTwo-hybridBioGRID16169070 
FAM173AC16orf24 | MGC2494family with sequence similarity 173, member ATwo-hybridBioGRID16169070 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)HTATIP (Tip60) interacts with the FAS promoter.BIND15829968 
GEMIN7SIP3gem (nuclear organelle) associated protein 7Two-hybridBioGRID16169070 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GSTO1DKFZp686H13163 | GSTTLp28 | P28glutathione S-transferase omega 1Two-hybridBioGRID16169070 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD11994312 
HDAC7DKFZp586J0917 | FLJ99588 | HD7A | HDAC7Ahistone deacetylase 7Affinity Capture-Western
Two-hybrid
BioGRID12551922 
HNRNPH32H9 | FLJ34092 | HNRPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)Two-hybridBioGRID16169070 
IKCSA2 | MGC59741 | REDIK cytokine, down-regulator of HLA IITwo-hybridBioGRID16169070 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5Affinity Capture-WesternBioGRID11416127 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3HTATIP (Tip60) interacts with the KLK3 (PSA) promoter.BIND15829968 
LMNACDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | PRO1lamin A/CTwo-hybridBioGRID16169070 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID12888553 
MAD2L1BPCMT2 | KIAA0110 | MGC11282 | RP1-261G23.6MAD2L1 binding proteinTwo-hybridBioGRID16169070 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD,BioGRID11927554 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID12776177 
NAP1L5DRLMnucleosome assembly protein 1-like 5Two-hybridBioGRID16169070 
NDUFA4L2FLJ26118 | NUOMSNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2Two-hybridBioGRID16169070 
NDUFV2-NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDaTwo-hybridBioGRID16169070 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1HTATIP (Tip60) interacts with NFKB1 (p50).BIND15829968 
OGFOD2DKFZp686H15154 | FLJ13491 | FLJ37501 | MGC120434 | MGC1204362-oxoglutarate and iron-dependent oxygenase domain containing 2Two-hybridBioGRID16169070 
PDCD5MGC9294 | TFAR19programmed cell death 5Two-hybridBioGRID16169070 
PLA2G4AMGC126350 | PLA2G4 | cPLA2-alphaphospholipase A2, group IVA (cytosolic, calcium-dependent)-HPRD,BioGRID11416127 
PLEKHA4PEPP1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4Two-hybridBioGRID16169070 
POLE2DPE2polymerase (DNA directed), epsilon 2 (p59 subunit)Two-hybridBioGRID16169070 
POLR3FMGC13517 | RPC39 | RPC6polymerase (RNA) III (DNA directed) polypeptide F, 39 kDaTwo-hybridBioGRID16169070 
PTPN4PTPMEG | PTPMEG1protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)Two-hybridBioGRID16169070 
PTPRSPTPSIGMAprotein tyrosine phosphatase, receptor type, STwo-hybridBioGRID16169070 
RGL2HKE1.5 | KE1.5 | RAB2Lral guanine nucleotide dissociation stimulator-like 2Two-hybridBioGRID16169070 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)HTATIP (Tip60) interacts with RUVBL1 (pontin).BIND15829968 
SAT1DC21 | KFSD | SAT | SSAT | SSAT-1spermidine/spermine N1-acetyltransferase 1Two-hybridBioGRID16169070 
SNAPINSNAPAPSNAP-associated proteinTwo-hybridBioGRID16169070 
SNRPD2SMD2 | SNRPD1small nuclear ribonucleoprotein D2 polypeptide 16.5kDaTwo-hybridBioGRID16169070 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID12551922 
SYN1SYN1a | SYN1b | SYNIsynapsin ITwo-hybridBioGRID16169070 
TRIB3C20orf97 | NIPK | SINK | SKIP3 | TRB3tribbles homolog 3 (Drosophila)Two-hybridBioGRID16169070 
ZEB1AREB6 | BZP | DELTA-EF1 | MGC133261 | NIL-2-A | NIL-2A | NIL2A | TCF8 | ZEB | ZFHEP | ZFHX1Azinc finger E-box binding homeobox 1-HPRD,BioGRID11275565 
ZNF24KOX17 | RSG-A | ZNF191 | ZSCAN3 | Zfp191zinc finger protein 24Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ST ERK1 ERK2 MAPK PATHWAY 3225All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY 2725All SZGR 2.0 genes in this pathway
PID P73PATHWAY 7959All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 7962All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 3425All SZGR 2.0 genes in this pathway
PID MYC PATHWAY 2522All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 5338All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 5943All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 4431All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 10874All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 7752All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN 8759All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway