Gene Page: IGF2BP1

Summary ?
GeneID10642
SymbolIGF2BP1
SynonymsCRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1
Descriptioninsulin like growth factor 2 mRNA binding protein 1
ReferenceMIM:608288|HGNC:HGNC:28866|Ensembl:ENSG00000159217|HPRD:09752|Vega:OTTHUMG00000161173
Gene typeprotein-coding
Map location17q21.32
Pascal p-value0.002
Fetal beta1.625
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg102513281747074713IGF2BP13.76E-8-0.0141.09E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ITM2A0.600.55
CALCRL0.590.62
LYVE10.590.60
LEPR0.580.52
OLFML30.570.44
ARHGAP290.570.55
C70.550.56
FGL20.550.52
EMCN0.550.55
OLFML10.540.52
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC026468.2-0.35-0.39
UCP3-0.34-0.35
QRICH2-0.34-0.34
RTEL1-0.34-0.35
UPF3A-0.34-0.36
SFRS16-0.33-0.35
AS3MT-0.33-0.36
ZNF296-0.33-0.36
AC132872.1-0.32-0.39
PABPN1-0.32-0.34

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 9758All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 10866All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN 5430All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 9772All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
BOYERINAS ONCOFETAL TARGETS OF LET7A1 129All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210128All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3 7959All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway