Summary ?
GeneID10683
SymbolDLL3
SynonymsSCDO1
Descriptiondelta-like 3 (Drosophila)
ReferenceMIM:602768|HGNC:HGNC:2909|Ensembl:ENSG00000090932|HPRD:04140|Vega:OTTHUMG00000183067
Gene typeprotein-coding
Map location19q13
Pascal p-value0.013
Sherlock p-value0.315
Fetal beta1.135
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg015198771939989802DLL32.73E-5-0.3670.018DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PDIA20.640.64
AL117190.30.630.69
PNPLA70.630.60
LIME10.620.62
ACADVL0.610.61
HSF40.580.60
TBC1D20.570.55
ITIH40.570.60
ACCN30.570.54
TBC1D10C0.560.57
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
USP9Y-0.43-0.46
LYPLA1-0.43-0.50
NLGN4Y-0.41-0.41
ZFY-0.41-0.46
DDX3Y-0.41-0.44
GPD2-0.41-0.47
AZIN1-0.40-0.47
UBE2D3-0.40-0.48
PTP4A1-0.40-0.44
GNB4-0.40-0.44

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOTCH SIGNALING PATHWAY 4735All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLIFIED IN PANCREATIC CANCER 3119All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP 2115All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN 3930All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL CARCINOMA VS ADENOMA UP 2113All SZGR 2.0 genes in this pathway
KUUSELO PANCREATIC CANCER 19Q13 AMPLIFICATION 3522All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
FUKUSHIMA TNFSF11 TARGETS 1614All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 DN 3921All SZGR 2.0 genes in this pathway