Gene Page: GMEB1
Summary ?
| GeneID | 10691 |
| Symbol | GMEB1 |
| Synonyms | P96PIF|PIF96 |
| Description | glucocorticoid modulatory element binding protein 1 |
| Reference | MIM:604409|HGNC:HGNC:4370|Ensembl:ENSG00000162419|HPRD:16059|Vega:OTTHUMG00000003647 |
| Gene type | protein-coding |
| Map location | 1p35.3 |
| Pascal p-value | 0.007 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | GMEB1 | 10691 | 0.01 | trans | ||
| rs16955618 | chr15 | 29937543 | GMEB1 | 10691 | 0.04 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| COG7 | 0.87 | 0.86 |
| ACAD10 | 0.86 | 0.85 |
| FAM160B2 | 0.85 | 0.87 |
| RHOT2 | 0.85 | 0.86 |
| CDK9 | 0.84 | 0.85 |
| SH2B1 | 0.83 | 0.86 |
| ZNF839 | 0.83 | 0.84 |
| NDST2 | 0.83 | 0.83 |
| TUBGCP6 | 0.83 | 0.86 |
| ATP8B2 | 0.83 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.66 | -0.60 |
| AF347015.31 | -0.63 | -0.54 |
| MT-CO2 | -0.60 | -0.52 |
| GNG11 | -0.58 | -0.57 |
| AF347015.8 | -0.57 | -0.50 |
| C1orf54 | -0.57 | -0.56 |
| AF347015.27 | -0.57 | -0.51 |
| MT-CYB | -0.56 | -0.48 |
| CLEC2B | -0.55 | -0.58 |
| AF347015.2 | -0.53 | -0.48 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | All SZGR 2.0 genes in this pathway |
| EBAUER TARGETS OF PAX3 FOXO1 FUSION UP | 207 | 128 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN UP | 181 | 112 | All SZGR 2.0 genes in this pathway |
| CHUNG BLISTER CYTOTOXICITY UP | 134 | 84 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |