Gene Page: RFPL3
Summary ?
| GeneID | 10738 |
| Symbol | RFPL3 |
| Synonyms | - |
| Description | ret finger protein like 3 |
| Reference | MIM:605970|HGNC:HGNC:9980|Ensembl:ENSG00000128276|HPRD:09339|Vega:OTTHUMG00000030290 |
| Gene type | protein-coding |
| Map location | 22q12.3 |
| Pascal p-value | 0.191 |
| Sherlock p-value | 0.192 |
| Fetal beta | -0.073 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs137547 | chr22 | 33311454 | RFPL3 | 10738 | 0 | cis | ||
| rs2611410 | chr3 | 60399847 | RFPL3 | 10738 | 0.06 | trans | ||
| rs10739219 | chr9 | 108938328 | RFPL3 | 10738 | 1.089E-4 | trans | ||
| rs1324669 | chr13 | 107872446 | RFPL3 | 10738 | 0.01 | trans | ||
| rs6132977 | chr20 | 2825971 | RFPL3 | 10738 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | TAS | 10508838 | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| CERIBELLI GENES INACTIVE AND BOUND BY NFY | 45 | 27 | All SZGR 2.0 genes in this pathway |