Gene Page: GRAP
Summary ?
| GeneID | 10750 |
| Symbol | GRAP |
| Synonyms | - |
| Description | GRB2-related adaptor protein |
| Reference | MIM:604330|HGNC:HGNC:4562|HPRD:05062| |
| Gene type | protein-coding |
| Map location | 17p11.2 |
| Pascal p-value | 2.375E-4 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DCTN1 | 0.90 | 0.90 |
| LENG4 | 0.90 | 0.90 |
| RANGAP1 | 0.90 | 0.88 |
| ATG9A | 0.88 | 0.86 |
| ATP6AP1 | 0.88 | 0.87 |
| IGSF8 | 0.88 | 0.85 |
| SLC27A4 | 0.88 | 0.90 |
| NUCB1 | 0.87 | 0.85 |
| SLC22A17 | 0.87 | 0.86 |
| GPI | 0.87 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.55 | -0.36 |
| GNG11 | -0.53 | -0.44 |
| AL050337.1 | -0.50 | -0.42 |
| C1orf54 | -0.49 | -0.36 |
| CLEC2B | -0.48 | -0.35 |
| FAM159B | -0.47 | -0.63 |
| SYCP3 | -0.47 | -0.44 |
| AP002478.3 | -0.46 | -0.38 |
| NOSTRIN | -0.46 | -0.33 |
| AF347015.18 | -0.44 | -0.28 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME SIGNALING BY SCF KIT | 78 | 59 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN | 74 | 44 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| BASSO CD40 SIGNALING DN | 68 | 44 | All SZGR 2.0 genes in this pathway |
| PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP | 131 | 87 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE DN | 204 | 114 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |