SZGR2

Summary ?

GeneID	108
Symbol	ADCY2
Synonyms	AC2\|HBAC2
Description	adenylate cyclase 2 (brain)
Reference	MIM:103071\|HGNC:HGNC:233\|Ensembl:ENSG00000078295\|HPRD:00052\|Vega:OTTHUMG00000090476
Gene type	protein-coding
Map location	5p15.3
Pascal p-value	0.103
Sherlock p-value	0.41
eGene	Myers' cis & trans Meta
Support	CANABINOID DOPAMINE INTRACELLULAR SIGNAL TRANSDUCTION SEROTONIN

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs989634	chr5	7822917	ADCY2	108	0.01	cis
rs4702502	chr5	7824001	ADCY2	108	0.01	cis
rs6506102	chr18	3277690	ADCY2	108	0.13	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PMEPA1	0.87	0.81
HTR6	0.87	0.68
GPR88	0.85	0.69
RASD2	0.84	0.61
PTPN5	0.83	0.80
GPR55	0.83	0.61
GPR6	0.82	0.46
PDE1B	0.82	0.63
DRD1	0.81	0.69
LINGO3	0.81	0.35

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.39	-0.59
SYCP3	-0.38	-0.61
LGALS3	-0.36	-0.53
GNG11	-0.36	-0.62
DBI	-0.35	-0.57
C1orf54	-0.35	-0.61
AF347015.31	-0.35	-0.51
AL139819.3	-0.35	-0.55
AF347015.2	-0.33	-0.42
CLEC2B	-0.33	-0.55

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000287	magnesium ion binding	IEA		-
GO:0004016	adenylate cyclase activity	NAS		1427768
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007242	intracellular signaling cascade	IEA		-
GO:0006171	cAMP biosynthetic process	NAS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0030425	dendrite	IEA	neuron, axon, dendrite (GO term level: 6)	-
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	NAS		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PURINE METABOLISM	159	96	All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY	92	68	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID LPA4 PATHWAY	15	10	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING	32	25	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS	30	23	All SZGR 2.0 genes in this pathway
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	10	8	All SZGR 2.0 genes in this pathway
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	13	9	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS	43	32	All SZGR 2.0 genes in this pathway
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	18	14	All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	413	270	All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	34	23	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS	195	114	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS	121	82	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	34	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	44	30	All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION	38	26	All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION	52	40	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN	244	153	All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN	258	141	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN	291	176	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP	68	41	All SZGR 2.0 genes in this pathway
MIDORIKAWA AMPLIFIED IN LIVER CANCER	55	38	All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN	103	59	All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR DN	46	34	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN	87	59	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 3	33	12	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 6	33	22	All SZGR 2.0 genes in this pathway
VALK AML WITH FLT3 ITD	40	22	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	190	196	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	190	196	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	187	193	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152	188	194	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-182	1258	1265	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-200bc/429	397	403	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-34b	2528	2534	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-361	380	386	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ADCY2