Gene Page: LILRB1

Summary ?
GeneID10859
SymbolLILRB1
SynonymsCD85J|ILT-2|ILT2|LIR-1|LIR1|MIR-7|MIR7
Descriptionleukocyte immunoglobulin like receptor B1
ReferenceMIM:604811|HGNC:HGNC:6605|Ensembl:ENSG00000104972|HPRD:07273|Vega:OTTHUMG00000065695
Gene typeprotein-coding
Map location19q13.4
Pascal p-value0.162
Fetal beta-0.425
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg017205201955127892LILRB15.431E-4-0.2720.048DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
COPZ10.890.86
MRPL30.880.87
RAN0.880.84
TAF70.870.87
PTGES30.870.85
PSMD60.870.83
FAF10.870.84
FBXO220.870.83
ATG120.860.85
RAD10.860.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.8-0.79-0.77
MT-CO2-0.77-0.75
AF347015.15-0.76-0.77
AF347015.2-0.75-0.73
AF347015.33-0.75-0.74
MT-CYB-0.75-0.75
AF347015.27-0.74-0.75
AF347015.26-0.73-0.73
AF347015.31-0.72-0.72
AF347015.21-0.72-0.70

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 7037All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 5129All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN 2818All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 5 3324All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 7646All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway