Gene Page: PPARGC1A
Summary ?
GeneID | 10891 |
Symbol | PPARGC1A |
Synonyms | LEM6|PGC-1(alpha)|PGC-1alpha|PGC-1v|PGC1|PGC1A|PPARGC1 |
Description | PPARG coactivator 1 alpha |
Reference | MIM:604517|HGNC:HGNC:9237|Ensembl:ENSG00000109819|HPRD:05155|Vega:OTTHUMG00000097747 |
Gene type | protein-coding |
Map location | 4p15.1 |
Pascal p-value | 0.011 |
Sherlock p-value | 0.004 |
Fetal beta | -2.1 |
DMG | 1 (# studies) |
Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg08811082 | 4 | 24474861 | PPARGC1A | 4.48E-8 | -0.007 | 1.23E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0000166 | nucleotide binding | IEA | - | |
GO:0003677 | DNA binding | TAS | 10713165 | |
GO:0003723 | RNA binding | TAS | 12588810 | |
GO:0008134 | transcription factor binding | TAS | 12588810 | |
GO:0016455 | RNA polymerase II transcription mediator activity | TAS | 14636573 | |
GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity | TAS | 12588810 | |
GO:0050681 | androgen receptor binding | NAS | 15572661 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0001659 | temperature homeostasis | TAS | 1258810 | |
GO:0001678 | cellular glucose homeostasis | NAS | 11854298 | |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | 14636573 | |
GO:0006397 | mRNA processing | TAS | 12588810 | |
GO:0008380 | RNA splicing | TAS | 12588810 | |
GO:0006461 | protein complex assembly | TAS | 14636573 | |
GO:0007586 | digestion | TAS | 10585775 | |
GO:0007005 | mitochondrion organization | NAS | 11854298 | |
GO:0042594 | response to starvation | NAS | 11854298 | |
GO:0050821 | protein stabilization | TAS | 14636573 | |
GO:0050873 | brown fat cell differentiation | TAS | 12588810 | |
GO:0035066 | positive regulation of histone acetylation | TAS | 14636573 | |
GO:0030521 | androgen receptor signaling pathway | NAS | 15572661 | |
GO:0045333 | cellular respiration | TAS | 11551810 | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IEA | - | |
GO:0045722 | positive regulation of gluconeogenesis | TAS | 12588810 | |
GO:0046321 | positive regulation of fatty acid oxidation | TAS | 12588810 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005634 | nucleus | TAS | 12588810 | |
GO:0005665 | DNA-directed RNA polymerase II, core complex | TAS | 12588810 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | - | HPRD,BioGRID | 10748020 |
ESRRG | DKFZp781L1617 | ERR3 | FLJ16023 | KIAA0832 | NR3B3 | estrogen-related receptor gamma | - | HPRD,BioGRID | 12470660 |
HCFC1 | CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAF | host cell factor C1 (VP16-accessory protein) | - | HPRD,BioGRID | 11733490 |
MED1 | CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2 | mediator complex subunit 1 | - | HPRD,BioGRID | 14636573 |
MED12 | CAGH45 | HOPA | KIAA0192 | OPA1 | TNRC11 | TRAP230 | mediator complex subunit 12 | Affinity Capture-Western Reconstituted Complex | BioGRID | 14636573 |
MED14 | CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170 | mediator complex subunit 14 | Affinity Capture-Western Reconstituted Complex | BioGRID | 14636573 |
MED16 | DRIP92 | THRAP5 | TRAP95 | mediator complex subunit 16 | Affinity Capture-Western | BioGRID | 14636573 |
MED17 | CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80 | mediator complex subunit 17 | Affinity Capture-Western Reconstituted Complex | BioGRID | 14636573 |
MED20 | DKFZp586D2223 | MGC29869 | PRO0213 | TRFP | mediator complex subunit 20 | Affinity Capture-Western | BioGRID | 14636573 |
MED21 | SRB7 | SURB7 | mediator complex subunit 21 | Affinity Capture-Western | BioGRID | 14636573 |
NCL | C23 | FLJ45706 | nucleolin | - | HPRD | 10983978 |
NCOA1 | F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42 | nuclear receptor coactivator 1 | - | HPRD,BioGRID | 10558993 |
NR1H4 | BAR | FXR | HRR-1 | HRR1 | MGC163445 | RIP14 | nuclear receptor subfamily 1, group H, member 4 | - | HPRD,BioGRID | 14729567 |
NR1I3 | CAR | CAR1 | MB67 | MGC150433 | MGC97144 | MGC97209 | nuclear receptor subfamily 1, group I, member 3 | CAR interacts with PGC-1. | BIND | 15572376 |
NR3C1 | GCCR | GCR | GR | GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | - | HPRD,BioGRID | 10713165 |
NRF1 | ALPHA-PAL | nuclear respiratory factor 1 | - | HPRD,BioGRID | 10412986 |11943463 |
PPARA | MGC2237 | MGC2452 | NR1C1 | PPAR | hPPAR | peroxisome proliferator-activated receptor alpha | - | HPRD,BioGRID | 10669761 |
PPARG | NR1C3 | PPARG1 | PPARG2 | PPARgamma | peroxisome proliferator-activated receptor gamma | - | HPRD | 12502716 |
PPARG | NR1C3 | PPARG1 | PPARG2 | PPARgamma | peroxisome proliferator-activated receptor gamma | Reconstituted Complex | BioGRID | 14636573 |
RXRA | FLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1 | retinoid X receptor, alpha | - | HPRD,BioGRID | 11714715 |
SFRS2 | PR264 | SC-35 | SC35 | SFRS2A | SRp30b | splicing factor, arginine/serine-rich 2 | Affinity Capture-Western | BioGRID | 10983978 |
SFRS4 | SRP75 | splicing factor, arginine/serine-rich 4 | Affinity Capture-Western | BioGRID | 10983978 |
SFRS5 | HRS | SRP40 | splicing factor, arginine/serine-rich 5 | Affinity Capture-Western | BioGRID | 10983978 |
SFRS6 | B52 | FLJ08061 | MGC5045 | SRP55 | splicing factor, arginine/serine-rich 6 | Affinity Capture-Western | BioGRID | 10983978 |
THRB | ERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | - | HPRD,BioGRID | 11751919 |
USF2 | FIP | bHLHb12 | upstream transcription factor 2, c-fos interacting | - | HPRD | 12611894 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG INSULIN SIGNALING PATHWAY | 137 | 103 | All SZGR 2.0 genes in this pathway |
KEGG ADIPOCYTOKINE SIGNALING PATHWAY | 67 | 57 | All SZGR 2.0 genes in this pathway |
KEGG HUNTINGTONS DISEASE | 185 | 109 | All SZGR 2.0 genes in this pathway |
BIOCARTA CARM ER PATHWAY | 35 | 27 | All SZGR 2.0 genes in this pathway |
BIOCARTA PPARA PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
BIOCARTA PGC1A PATHWAY | 26 | 20 | All SZGR 2.0 genes in this pathway |
PID HDAC CLASSIII PATHWAY | 25 | 20 | All SZGR 2.0 genes in this pathway |
PID MTOR 4PATHWAY | 69 | 55 | All SZGR 2.0 genes in this pathway |
PID ATF2 PATHWAY | 59 | 43 | All SZGR 2.0 genes in this pathway |
PID P38 ALPHA BETA DOWNSTREAM PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | 36 | 27 | All SZGR 2.0 genes in this pathway |
REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | All SZGR 2.0 genes in this pathway |
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 24 | 17 | All SZGR 2.0 genes in this pathway |
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 23 | 16 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
REACTOME CIRCADIAN CLOCK | 53 | 40 | All SZGR 2.0 genes in this pathway |
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | All SZGR 2.0 genes in this pathway |
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP | 276 | 165 | All SZGR 2.0 genes in this pathway |
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP | 139 | 83 | All SZGR 2.0 genes in this pathway |
MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
HELLER SILENCED BY METHYLATION DN | 105 | 67 | All SZGR 2.0 genes in this pathway |
WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
CADWELL ATG16L1 TARGETS DN | 70 | 43 | All SZGR 2.0 genes in this pathway |
YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA PCA3 UP | 80 | 54 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |
GUO TARGETS OF IRS1 AND IRS2 | 98 | 67 | All SZGR 2.0 genes in this pathway |
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |
CHEMELLO SOLEUS VS EDL MYOFIBERS UP | 35 | 16 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
let-7/98 | 38 | 44 | 1A | hsa-let-7abrain | UGAGGUAGUAGGUUGUAUAGUU |
hsa-let-7bbrain | UGAGGUAGUAGGUUGUGUGGUU | ||||
hsa-let-7cbrain | UGAGGUAGUAGGUUGUAUGGUU | ||||
hsa-let-7dbrain | AGAGGUAGUAGGUUGCAUAGU | ||||
hsa-let-7ebrain | UGAGGUAGGAGGUUGUAUAGU | ||||
hsa-let-7fbrain | UGAGGUAGUAGAUUGUAUAGUU | ||||
hsa-miR-98brain | UGAGGUAGUAAGUUGUAUUGUU | ||||
hsa-let-7gSZ | UGAGGUAGUAGUUUGUACAGU | ||||
hsa-let-7ibrain | UGAGGUAGUAGUUUGUGCUGU | ||||
miR-136 | 1092 | 1098 | m8 | hsa-miR-136 | ACUCCAUUUGUUUUGAUGAUGGA |
miR-137 | 2656 | 2662 | 1A | hsa-miR-137 | UAUUGCUUAAGAAUACGCGUAG |
hsa-miR-137 | UAUUGCUUAAGAAUACGCGUAG | ||||
miR-138 | 2360 | 2367 | 1A,m8 | hsa-miR-138brain | AGCUGGUGUUGUGAAUC |
miR-139 | 3453 | 3459 | m8 | hsa-miR-139brain | UCUACAGUGCACGUGUCU |
miR-148/152 | 1152 | 1158 | m8 | hsa-miR-148a | UCAGUGCACUACAGAACUUUGU |
hsa-miR-152brain | UCAGUGCAUGACAGAACUUGGG | ||||
hsa-miR-148b | UCAGUGCAUCACAGAACUUUGU | ||||
miR-150 | 805 | 811 | 1A | hsa-miR-150 | UCUCCCAACCCUUGUACCAGUG |
miR-153 | 1149 | 1155 | m8 | hsa-miR-153 | UUGCAUAGUCACAAAAGUGA |
miR-193 | 1754 | 1760 | 1A | hsa-miR-193a | AACUGGCCUACAAAGUCCCAG |
hsa-miR-193b | AACUGGCCCUCAAAGUCCCGCUUU | ||||
miR-194 | 1141 | 1147 | 1A | hsa-miR-194 | UGUAACAGCAACUCCAUGUGGA |
miR-199 | 1485 | 1492 | 1A,m8 | hsa-miR-199a | CCCAGUGUUCAGACUACCUGUUC |
hsa-miR-199b | CCCAGUGUUUAGACUAUCUGUUC | ||||
miR-204/211 | 3776 | 3783 | 1A,m8 | hsa-miR-204brain | UUCCCUUUGUCAUCCUAUGCCU |
hsa-miR-211 | UUCCCUUUGUCAUCCUUCGCCU | ||||
miR-214 | 194 | 200 | 1A | hsa-miR-214brain | ACAGCAGGCACAGACAGGCAG |
miR-217 | 3746 | 3752 | 1A | hsa-miR-217 | UACUGCAUCAGGAACUGAUUGGAU |
miR-218 | 229 | 235 | m8 | hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU |
miR-219 | 698 | 704 | m8 | hsa-miR-219brain | UGAUUGUCCAAACGCAAUUCU |
miR-22 | 2329 | 2335 | 1A | hsa-miR-22brain | AAGCUGCCAGUUGAAGAACUGU |
miR-221/222 | 3222 | 3229 | 1A,m8 | hsa-miR-221brain | AGCUACAUUGUCUGCUGGGUUUC |
hsa-miR-222brain | AGCUACAUCUGGCUACUGGGUCUC | ||||
miR-23 | 3504 | 3510 | m8 | hsa-miR-23abrain | AUCACAUUGCCAGGGAUUUCC |
hsa-miR-23bbrain | AUCACAUUGCCAGGGAUUACC | ||||
hsa-miR-23abrain | AUCACAUUGCCAGGGAUUUCC | ||||
hsa-miR-23bbrain | AUCACAUUGCCAGGGAUUACC | ||||
miR-29 | 3181 | 3187 | m8 | hsa-miR-29aSZ | UAGCACCAUCUGAAAUCGGUU |
hsa-miR-29bSZ | UAGCACCAUUUGAAAUCAGUGUU | ||||
hsa-miR-29cSZ | UAGCACCAUUUGAAAUCGGU | ||||
miR-30-5p | 1850 | 1856 | m8 | hsa-miR-30a-5p | UGUAAACAUCCUCGACUGGAAG |
hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
hsa-miR-30bSZ | UGUAAACAUCCUACACUCAGCU | ||||
hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
hsa-miR-30a-5p | UGUAAACAUCCUCGACUGGAAG | ||||
hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
hsa-miR-30bSZ | UGUAAACAUCCUACACUCAGCU | ||||
hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
hsa-miR-30a-5p | UGUAAACAUCCUCGACUGGAAG | ||||
hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
hsa-miR-30bSZ | UGUAAACAUCCUACACUCAGCU | ||||
hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
miR-320 | 253 | 259 | m8 | hsa-miR-320 | AAAAGCUGGGUUGAGAGGGCGAA |
miR-323 | 3549 | 3556 | 1A,m8 | hsa-miR-323brain | GCACAUUACACGGUCGACCUCU |
hsa-miR-323brain | GCACAUUACACGGUCGACCUCU | ||||
miR-33 | 2325 | 2331 | m8 | hsa-miR-33 | GUGCAUUGUAGUUGCAUUG |
hsa-miR-33b | GUGCAUUGCUGUUGCAUUGCA | ||||
miR-369-3p | 1893 | 1899 | 1A | hsa-miR-369-3p | AAUAAUACAUGGUUGAUCUUU |
miR-374 | 1893 | 1900 | 1A,m8 | hsa-miR-374 | UUAUAAUACAACCUGAUAAGUG |
miR-410 | 1275 | 1281 | 1A | hsa-miR-410 | AAUAUAACACAGAUGGCCUGU |
miR-433-3p | 1540 | 1546 | m8 | hsa-miR-433brain | AUCAUGAUGGGCUCCUCGGUGU |
miR-485-3p | 3714 | 3721 | 1A,m8 | hsa-miR-485-3p | GUCAUACACGGCUCUCCUCUCU |
miR-485-5p | 3758 | 3765 | 1A,m8 | hsa-miR-485-5p | AGAGGCUGGCCGUGAUGAAUUC |
miR-494 | 3788 | 3795 | 1A,m8 | hsa-miR-494brain | UGAAACAUACACGGGAAACCUCUU |
miR-495 | 1139 | 1145 | 1A | hsa-miR-495brain | AAACAAACAUGGUGCACUUCUUU |
hsa-miR-495brain | AAACAAACAUGGUGCACUUCUUU | ||||
miR-496 | 1551 | 1557 | 1A | hsa-miR-496 | AUUACAUGGCCAAUCUC |
miR-539 | 93 | 99 | m8 | hsa-miR-539 | GGAGAAAUUAUCCUUGGUGUGU |
hsa-miR-539 | GGAGAAAUUAUCCUUGGUGUGU | ||||
miR-543 | 3786 | 3792 | m8 | hsa-miR-543 | AAACAUUCGCGGUGCACUUCU |
miR-7 | 911 | 917 | 1A | hsa-miR-7SZ | UGGAAGACUAGUGAUUUUGUUG |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.