Summary ?
GeneID10891
SymbolPPARGC1A
SynonymsLEM6|PGC-1(alpha)|PGC-1alpha|PGC-1v|PGC1|PGC1A|PPARGC1
DescriptionPPARG coactivator 1 alpha
ReferenceMIM:604517|HGNC:HGNC:9237|Ensembl:ENSG00000109819|HPRD:05155|Vega:OTTHUMG00000097747
Gene typeprotein-coding
Map location4p15.1
Pascal p-value0.011
Sherlock p-value0.004
Fetal beta-2.1
DMG1 (# studies)
SupportCompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg08811082424474861PPARGC1A4.48E-8-0.0071.23E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingTAS10713165 
GO:0003723RNA bindingTAS12588810 
GO:0008134transcription factor bindingTAS12588810 
GO:0016455RNA polymerase II transcription mediator activityTAS14636573 
GO:0030374ligand-dependent nuclear receptor transcription coactivator activityTAS12588810 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001659temperature homeostasisTAS1258810 
GO:0001678cellular glucose homeostasisNAS11854298 
GO:0006367transcription initiation from RNA polymerase II promoterTAS14636573 
GO:0006397mRNA processingTAS12588810 
GO:0008380RNA splicingTAS12588810 
GO:0006461protein complex assemblyTAS14636573 
GO:0007586digestionTAS10585775 
GO:0007005mitochondrion organizationNAS11854298 
GO:0042594response to starvationNAS11854298 
GO:0050821protein stabilizationTAS14636573 
GO:0050873brown fat cell differentiationTAS12588810 
GO:0035066positive regulation of histone acetylationTAS14636573 
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045333cellular respirationTAS11551810 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045722positive regulation of gluconeogenesisTAS12588810 
GO:0046321positive regulation of fatty acid oxidationTAS12588810 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS12588810 
GO:0005665DNA-directed RNA polymerase II, core complexTAS12588810 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID10748020 
ESRRGDKFZp781L1617 | ERR3 | FLJ16023 | KIAA0832 | NR3B3estrogen-related receptor gamma-HPRD,BioGRID12470660 
HCFC1CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAFhost cell factor C1 (VP16-accessory protein)-HPRD,BioGRID11733490 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1-HPRD,BioGRID14636573 
MED12CAGH45 | HOPA | KIAA0192 | OPA1 | TNRC11 | TRAP230mediator complex subunit 12Affinity Capture-Western
Reconstituted Complex
BioGRID14636573 
MED14CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170mediator complex subunit 14Affinity Capture-Western
Reconstituted Complex
BioGRID14636573 
MED16DRIP92 | THRAP5 | TRAP95mediator complex subunit 16Affinity Capture-WesternBioGRID14636573 
MED17CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80mediator complex subunit 17Affinity Capture-Western
Reconstituted Complex
BioGRID14636573 
MED20DKFZp586D2223 | MGC29869 | PRO0213 | TRFPmediator complex subunit 20Affinity Capture-WesternBioGRID14636573 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-WesternBioGRID14636573 
NCLC23 | FLJ45706nucleolin-HPRD10983978 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID10558993 
NR1H4BAR | FXR | HRR-1 | HRR1 | MGC163445 | RIP14nuclear receptor subfamily 1, group H, member 4-HPRD,BioGRID14729567 
NR1I3CAR | CAR1 | MB67 | MGC150433 | MGC97144 | MGC97209nuclear receptor subfamily 1, group I, member 3CAR interacts with PGC-1.BIND15572376 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID10713165 
NRF1ALPHA-PALnuclear respiratory factor 1-HPRD,BioGRID10412986 |11943463 
PPARAMGC2237 | MGC2452 | NR1C1 | PPAR | hPPARperoxisome proliferator-activated receptor alpha-HPRD,BioGRID10669761 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gamma-HPRD12502716 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gammaReconstituted ComplexBioGRID14636573 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID11714715 
SFRS2PR264 | SC-35 | SC35 | SFRS2A | SRp30bsplicing factor, arginine/serine-rich 2Affinity Capture-WesternBioGRID10983978 
SFRS4SRP75splicing factor, arginine/serine-rich 4Affinity Capture-WesternBioGRID10983978 
SFRS5HRS | SRP40splicing factor, arginine/serine-rich 5Affinity Capture-WesternBioGRID10983978 
SFRS6B52 | FLJ08061 | MGC5045 | SRP55splicing factor, arginine/serine-rich 6Affinity Capture-WesternBioGRID10983978 
THRBERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)-HPRD,BioGRID11751919 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interacting-HPRD12611894 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 6757All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY 3527All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY 2620All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY 2520All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 5943All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 3829All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 3627All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 2417All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 2316All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 5340All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276165All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 13983All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341197All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN 7043All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 7651All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP 8054All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2 9867All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289184All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 3516All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9838441Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-13610921098m8hsa-miR-136ACUCCAUUUGUUUUGAUGAUGGA
miR-137265626621Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-138236023671A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-13934533459m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-148/15211521158m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1508058111Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-15311491155m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-193175417601Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-194114111471Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-199148514921A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-204/211377637831A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2141942001Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-217374637521Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-218229235m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-219698704m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-22232923351Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-221/222322232291A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-2335043510m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-2931813187m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-5p18501856m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-320253259m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-323354935561A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3323252331m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-369-3p189318991Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374189319001A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-410127512811Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-433-3p15401546m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-485-3p371437211A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-485-5p375837651A,m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-494378837951A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-495113911451Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496155115571Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-5399399m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-54337863792m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-79119171Ahsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG