SZGR2

Summary ?

GeneID	10921
Symbol	RNPS1
Synonyms	E5.1
Description	RNA binding protein S1, serine-rich domain
Reference	MIM:606447\|HGNC:HGNC:10080\|Ensembl:ENSG00000205937\|HPRD:07341\|Vega:OTTHUMG00000128828
Gene type	protein-coding
Map location	16p13.3
Pascal p-value	0.181
Sherlock p-value	0.593
Fetal beta	0.252
DMG	1 (# studies)
eGene	Cerebellar Hemisphere Cerebellum Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg06728335	16	2318300	RNPS1		-0.021	0.79	DMG:Nishioka_2013

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs17795337	chr6	136492658	RNPS1	10921		0.19		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TMEM85	0.83	0.78
POP4	0.82	0.77
PDCD6	0.82	0.78
PRKAG1	0.82	0.77
SNX11	0.81	0.78
DRG2	0.81	0.77
NIT1	0.81	0.77
STOML2	0.81	0.77
WDR61	0.80	0.73
MRPS7	0.80	0.75

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.18	-0.60	-0.44
AC010300.1	-0.59	-0.62
AC100783.1	-0.52	-0.39
AF347015.26	-0.49	-0.32
C10orf108	-0.48	-0.40
AC016705.1	-0.48	-0.41
AC073957.1	-0.47	-0.41
AF347015.2	-0.47	-0.27
AF347015.8	-0.44	-0.27
MT-ATP8	-0.44	-0.29

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AP2B1	ADTB2 \| AP105B \| AP2-BETA \| CLAPB1 \| DKFZp781K0743	adaptor-related protein complex 2, beta 1 subunit	Affinity Capture-MS	BioGRID	17353931
ARS2	ASR2 \| MGC126427	arsenate resistance protein 2	Affinity Capture-MS	BioGRID	17353931
C14orf102	FLJ10008 \| FLJ14051	chromosome 14 open reading frame 102	Affinity Capture-MS	BioGRID	17353931
C19orf29	NY-REN-24 \| cactin \| fSAPc	chromosome 19 open reading frame 29	Affinity Capture-MS	BioGRID	17353931
C20orf11	TWA1	chromosome 20 open reading frame 11	Affinity Capture-MS	BioGRID	17353931
CDC2L1	CDC2L2 \| CDK11 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| CLK-1 \| FLJ59152 \| PK58 \| p58 \| p58CDC2L1 \| p58CLK-1	cell division cycle 2-like 1 (PITSLRE proteins)	Affinity Capture-MS	BioGRID	17353931
CDC2L2	CDC2L3 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| MGC131975 \| PITSLRE \| p58GTA	cell division cycle 2-like 2 (PITSLRE proteins)	-	HPRD,BioGRID	9580558
CPSF2	CPSF100 \| KIAA1367	cleavage and polyadenylation specific factor 2, 100kDa	Affinity Capture-MS	BioGRID	17353931
CPSF6	CFIM \| CFIM68 \| HPBRII-4 \| HPBRII-7	cleavage and polyadenylation specific factor 6, 68kDa	Affinity Capture-MS	BioGRID	17353931
CROP	LUC7A \| OA48-18	cisplatin resistance-associated overexpressed protein	Affinity Capture-MS	BioGRID	17353931
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Affinity Capture-MS	BioGRID	17353931
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	Affinity Capture-MS	BioGRID	17353931
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	Affinity Capture-MS	BioGRID	17353931
DDX20	DKFZp434H052 \| DP103 \| GEMIN3	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	Affinity Capture-MS	BioGRID	17353931
DDX23	MGC8416 \| PRPF28 \| U5-100K \| U5-100KD \| prp28	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	Affinity Capture-MS	BioGRID	17353931
DDX41	ABS \| MGC8828	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	Affinity Capture-MS	BioGRID	17353931
DHX38	DDX38 \| KIAA0224 \| PRP16 \| PRPF16	DEAH (Asp-Glu-Ala-His) box polypeptide 38	Affinity Capture-MS	BioGRID	17353931
DVL2	-	dishevelled, dsh homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
EFTUD2	DKFZp686E24196 \| FLJ44695 \| KIAA0031 \| Snrp116 \| Snu114 \| U5-116KD	elongation factor Tu GTP binding domain containing 2	Affinity Capture-MS	BioGRID	17353931
FIP1L1	DKFZp586K0717 \| FLJ33619 \| Rhe	FIP1 like 1 (S. cerevisiae)	RNPS1 interacts with DKFZp586K0717.	BIND	14729963
GEMIN4	DKFZp434B131 \| DKFZp434D174 \| HC56 \| HCAP1 \| HHRF-1 \| p97	gem (nuclear organelle) associated protein 4	Affinity Capture-MS	BioGRID	17353931
KHK	-	ketohexokinase (fructokinase)	Affinity Capture-MS	BioGRID	17353931
LUC7L	FLJ10231 \| LUC7-LIKE \| LUC7B1 \| SR+89	LUC7-like (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
MKLN1	FLJ11162 \| TWA2	muskelin 1, intracellular mediator containing kelch motifs	Affinity Capture-MS	BioGRID	17353931
NKTR	DKFZp686F1754 \| DKFZp686G0426 \| DKFZp686J06106 \| DKFZp686N24126 \| MGC90527 \| p104	natural killer-tumor recognition sequence	RNPS1 interacts with NKTR.	BIND	14729963
NUDT21	CFIM25 \| CPSF5 \| DKFZp686H1588	nudix (nucleoside diphosphate linked moiety X)-type motif 21	Affinity Capture-MS	BioGRID	17353931
PNN	DRS \| SDK3 \| memA \| pinin	pinin, desmosome associated protein	-	HPRD,BioGRID	14517304
PRPF3	HPRP3 \| HPRP3P \| PRP3 \| Prp3p \| RP18	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
PRPF40A	FBP-11 \| FBP11 \| FLAF1 \| FLJ20585 \| FNBP3 \| HIP10 \| HYPA \| NY-REN-6	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
PRPF4B	KIAA0536 \| PR4H \| PRP4 \| PRP4H \| PRP4K \| dJ1013A10.1	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	Affinity Capture-MS	BioGRID	17353931
PRPF6	ANT-1 \| C20orf14 \| TOM \| U5-102K \| hPrp6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
PRPF8	HPRP8 \| PRP8 \| PRPC8 \| RP13	PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
PSME3	Ki \| PA28-gamma \| PA28G \| REG-GAMMA	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	Affinity Capture-MS	BioGRID	17353931
PUF60	FIR \| FLJ31379 \| RoBPI \| SIAHBP1	poly-U binding splicing factor 60KDa	Affinity Capture-MS	BioGRID	17353931
RANBP9	RANBPM	RAN binding protein 9	Affinity Capture-MS	BioGRID	17353931
RARS	ArgRS \| DALRD1 \| MGC8641	arginyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931
RBM25	MGC105088 \| MGC117168 \| RED120 \| RNPC7 \| S164 \| fSAP94	RNA binding motif protein 25	Affinity Capture-MS	BioGRID	17353931
RBM8A	BOV-1A \| BOV-1B \| BOV-1C \| MDS014 \| RBM8 \| RBM8B \| Y14 \| ZNRP \| ZRNP1	RNA binding motif protein 8A	Reconstituted Complex	BioGRID	11707413
SART3	DSAP1 \| KIAA0156 \| MGC138188 \| P100 \| RP11-13G14 \| TIP110 \| p110 \| p110(nrb)	squamous cell carcinoma antigen recognized by T cells 3	-	HPRD,BioGRID	11477570
SF3B1	PRP10 \| PRPF10 \| SAP155 \| SF3b155	splicing factor 3b, subunit 1, 155kDa	Affinity Capture-MS	BioGRID	17353931
SF3B3	KIAA0017 \| RSE1 \| SAP130 \| SF3b130 \| STAF130	splicing factor 3b, subunit 3, 130kDa	Affinity Capture-MS	BioGRID	17353931
SFRS1	ASF \| MGC5228 \| SF2 \| SF2p33 \| SRp30a	splicing factor, arginine/serine-rich 1	Affinity Capture-MS	BioGRID	17353931
SFRS10	DKFZp686F18120 \| Htra2-beta \| SRFS10 \| TRA2-BETA \| TRA2B \| TRAN2B	splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)	RNPS1 interacts with hTra2-beta.	BIND	14729963
SFRS10	DKFZp686F18120 \| Htra2-beta \| SRFS10 \| TRA2-BETA \| TRA2B \| TRAN2B	splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)	Affinity Capture-MS	BioGRID	17353931
SFRS11	DKFZp686M13204 \| dJ677H15.2 \| p54	splicing factor, arginine/serine-rich 11	RNPS1 interacts with p54.	BIND	14729963
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	Affinity Capture-MS	BioGRID	17353931
SFRS2	PR264 \| SC-35 \| SC35 \| SFRS2A \| SRp30b	splicing factor, arginine/serine-rich 2	Affinity Capture-MS	BioGRID	17353931
SFRS6	B52 \| FLJ08061 \| MGC5045 \| SRP55	splicing factor, arginine/serine-rich 6	Two-hybrid	BioGRID	16189514
SFRS7	9G8 \| AAG3	splicing factor, arginine/serine-rich 7, 35kDa	Affinity Capture-MS	BioGRID	17353931
SFRS8	MGC167082 \| SWAP	splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)	Affinity Capture-MS	BioGRID	17353931
SIP1	GEMIN2 \| SIP1-delta	survival of motor neuron protein interacting protein 1	Affinity Capture-MS	BioGRID	17353931
SKIV2L2	Dob1 \| KIAA0052 \| MGC142069 \| Mtr4 \| fSAP118	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
SNRNP200	ASCC3L1 \| BRR2 \| HELIC2 \| U5-200KD	small nuclear ribonucleoprotein 200kDa (U5)	Affinity Capture-MS	BioGRID	17353931
SNRNP70	RNPU1Z \| RPU1 \| SNRP70 \| U170K \| U1AP \| U1RNP	small nuclear ribonucleoprotein 70kDa (U1)	Affinity Capture-MS	BioGRID	17353931
SNRPA	U1A	small nuclear ribonucleoprotein polypeptide A	Affinity Capture-MS	BioGRID	17353931
SRPK1	SFRSK1	SFRS protein kinase 1	Affinity Capture-MS	BioGRID	17353931
SRPK2	FLJ36101 \| SFRSK2	SFRS protein kinase 2	Affinity Capture-MS	BioGRID	17353931
SRRM1	160-KD \| MGC39488 \| POP101 \| SRM160	serine/arginine repetitive matrix 1	-	HPRD,BioGRID	12093754
SRRM2	300-KD \| CWF21 \| DKFZp686O15166 \| FLJ21926 \| FLJ22250 \| KIAA0324 \| MGC40295 \| SRL300 \| SRm300	serine/arginine repetitive matrix 2	Affinity Capture-MS	BioGRID	17353931
STRAP	MAWD \| PT-WD \| UNRIP	serine/threonine kinase receptor associated protein	Affinity Capture-MS	BioGRID	17353931
TAF2	CIF150 \| TAF2B \| TAFII150	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	RNPS1 interacts with CIF150.	BIND	14729963
THRAP3	FLJ22082 \| MGC133082 \| MGC133083 \| TRAP150	thyroid hormone receptor associated protein 3	Affinity Capture-MS	BioGRID	17353931
U2AF2	U2AF65	U2 small nuclear RNA auxiliary factor 2	Affinity Capture-MS	BioGRID	17353931
USP7	HAUSP \| TEF1	ubiquitin specific peptidase 7 (herpes virus-associated)	Affinity Capture-MS	BioGRID	17353931
WDR33	FLJ11294 \| WDC146	WD repeat domain 33	Affinity Capture-MS	BioGRID	17353931
ZFR	FLJ41312 \| ZFR1	zinc finger RNA binding protein	RNPS1 interacts with Zfr.	BIND	14729963

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	140	77	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	54	34	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION	105	54	All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING	161	86	All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING	111	58	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
REACTOME MRNA 3 END PROCESSING	35	18	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	44	22	All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	176	57	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP	92	57	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN	180	101	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP	112	68	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE	19	15	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M	216	124	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway

Gene Page: RNPS1