Gene Page: IFT27

Summary ?
GeneID11020
SymbolIFT27
SynonymsBBS19|RABL4|RAYL
Descriptionintraflagellar transport 27
ReferenceMIM:615870|HGNC:HGNC:18626|Ensembl:ENSG00000100360|Vega:OTTHUMG00000150544
Gene typeprotein-coding
Map location22q13.1
Pascal p-value0.008
Sherlock p-value0.717
Fetal beta-0.783
eGeneCaudate basal ganglia
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs38273512237157240IFT27ENSG00000100360.108.50745E-70.0115060gtex_brain_putamen_basal
rs10480152237163080IFT27ENSG00000100360.102.96297E-60.019220gtex_brain_putamen_basal
rs57503062237170915IFT27ENSG00000100360.101.0358E-60.011385gtex_brain_putamen_basal
rs57503072237170977IFT27ENSG00000100360.101.0358E-60.011323gtex_brain_putamen_basal
rs81352842237182681IFT27ENSG00000100360.101.9563E-60.01-10381gtex_brain_putamen_basal
rs96073822237191418IFT27ENSG00000100360.103.33923E-60.01-19118gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HDAC60.960.96
RAF10.960.94
DCAF150.950.95
JUP0.950.94
RBM15B0.950.95
CSNK1E0.950.94
IFT1400.950.95
AKT10.950.94
EHMT20.940.95
NUP620.940.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.77-0.78
AF347015.27-0.77-0.88
AF347015.31-0.76-0.87
MT-CO2-0.75-0.88
AF347015.33-0.74-0.85
S100B-0.74-0.82
HLA-F-0.73-0.73
MT-CYB-0.72-0.84
AIFM3-0.72-0.71
AF347015.8-0.72-0.86

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FLI1 98All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287208All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473224All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway