Gene Page: CHAT

Summary ?
GeneID1103
SymbolCHAT
SynonymsCHOACTASE|CMS1A|CMS1A2|CMS6
Descriptioncholine O-acetyltransferase
ReferenceMIM:118490|HGNC:HGNC:1912|Ensembl:ENSG00000070748|HPRD:07510|Vega:OTTHUMG00000018198
Gene typeprotein-coding
Map location10q11.2
Pascal p-value0.51
Fetal beta-1.749
SupportNEUROTRANSMITTER METABOLISM

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FBXO50.960.86
TTK0.950.87
PLK40.950.88
HELLS0.950.77
MELK0.950.82
KIF230.940.83
GINS10.940.83
BRIP10.940.83
SMC40.940.87
CEP550.940.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-F-0.51-0.78
C5orf53-0.51-0.73
PTH1R-0.50-0.74
AIFM3-0.50-0.77
FBXO2-0.50-0.67
ALDOC-0.49-0.73
AF347015.31-0.48-0.82
AF347015.27-0.48-0.81
CA4-0.48-0.74
TNFSF12-0.48-0.68

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004102choline O-acetyltransferase activityIEA-
GO:0016740transferase activityIEA-
GO:0008415acyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030182neuron differentiationIEAneuron (GO term level: 8)-
GO:0007274neuromuscular synaptic transmissionIEAneuron, Synap (GO term level: 7)-
GO:0043179rhythmic excitationIEASynap (GO term level: 9)-
GO:0042136neurotransmitter biosynthetic processIEAneuron, axon, Synap, Neurotransmitter (GO term level: 9)-
GO:0007529establishment of synaptic specificity at neuromuscular junctionIEAneuron, Synap (GO term level: 11)-
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0007517muscle developmentIEA-
GO:0007628adult walking behaviorIEA-
GO:0007622rhythmic behaviorIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0005634nucleusTAS10861222 
GO:0005737cytoplasmTAS10861222 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCEROPHOSPHOLIPID METABOLISM 7735All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PC 189All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 8239All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RELEASE CYCLE 3430All SZGR 2.0 genes in this pathway
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 109All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196124All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
NOUSHMEHR GBM GERMLINE MUTATED 85All SZGR 2.0 genes in this pathway