Gene Page: CHAT

Summary
GeneID  1103
Symbol  CHAT
Synonyms  CMS1A|CMS1A2
Description  choline acetyltransferase
See related  HGNC:1912|MIM:118490|Ensembl:ENSG00000070748|HPRD:07510|
Locus tag  -
Gene type  protein-coding
Map location  10q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FBXO50.960.86
TTK0.950.87
PLK40.950.88
HELLS0.950.77
MELK0.950.82
KIF230.940.83
GINS10.940.83
BRIP10.940.83
SMC40.940.87
CEP550.940.80
Top 10 negatively co-expressed genes
HLA-F-0.51-0.78
C5orf53-0.51-0.73
PTH1R-0.50-0.74
AIFM3-0.50-0.77
FBXO2-0.50-0.67
ALDOC-0.49-0.73
AF347015.31-0.48-0.82
AF347015.27-0.48-0.81
CA4-0.48-0.74
TNFSF12-0.48-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004102choline O-acetyltransferase activityIEA-
GO:0016740transferase activityIEA-
GO:0008415acyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030182neuron differentiationIEAneuron (GO term level: 8)-
GO:0007274neuromuscular synaptic transmissionIEAneuron, Synap (GO term level: 7)-
GO:0043179rhythmic excitationIEASynap (GO term level: 9)-
GO:0042136neurotransmitter biosynthetic processIEAneuron, axon, Synap, Neurotransmitter (GO term level: 9)-
GO:0007529establishment of synaptic specificity at neuromuscular junctionIEAneuron, Synap (GO term level: 11)-
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0007517muscle developmentIEA-
GO:0007628adult walking behaviorIEA-
GO:0007622rhythmic behaviorIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0005634nucleusTAS10861222 
GO:0005737cytoplasmTAS10861222 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD10692442 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 7735All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_PC 189All SZGR genes in this pathway
REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS 8239All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 109All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
NOUSHMEHR_GBM_GERMLINE_MUTATED 85All SZGR genes in this pathway


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