Gene Page: NUDT21
Summary ?
| GeneID | 11051 |
| Symbol | NUDT21 |
| Synonyms | CFIM25|CPSF5 |
| Description | nudix hydrolase 21 |
| Reference | MIM:604978|HGNC:HGNC:13870|Ensembl:ENSG00000167005|HPRD:05400|Vega:OTTHUMG00000133240 |
| Gene type | protein-coding |
| Map location | 16q12.2 |
| Pascal p-value | 0.11 |
| Sherlock p-value | 0.767 |
| Fetal beta | 0.158 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0813 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg03619472 | 16 | 56486263 | NUDT21 | -0.024 | 0.25 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9880715 | chr3 | 71081864 | NUDT21 | 11051 | 0.02 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NAGS | 0.95 | 0.23 |
| ZIC4 | 0.94 | 0.57 |
| ZIC2 | 0.93 | 0.64 |
| ZIC1 | 0.92 | 0.64 |
| PROX1 | 0.91 | 0.40 |
| GBX2 | 0.88 | 0.26 |
| KITLG | 0.88 | 0.20 |
| CD247 | 0.87 | 0.20 |
| KRT18P19 | 0.86 | 0.07 |
| LHX9 | 0.85 | 0.14 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC26A4 | -0.17 | -0.20 |
| C11orf51 | -0.16 | -0.38 |
| GTDC1 | -0.16 | -0.14 |
| MTIF3 | -0.15 | -0.40 |
| KIAA1614 | -0.15 | 0.08 |
| C20orf39 | -0.14 | 0.09 |
| GRIA3 | -0.14 | -0.00 |
| CRYM | -0.14 | -0.20 |
| THYN1 | -0.14 | -0.22 |
| CACNG3 | -0.13 | 0.01 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 8626397 | |
| GO:0005515 | protein binding | IPI | 11716503 |14561889 |15169763 | |
| GO:0016787 | hydrolase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | EXP | 12226669 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005813 | centrosome | IDA | 11256614 | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0042382 | paraspeckles | IDA | 15169763 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| C7orf64 | DKFZP564O0523 | DKFZp686D1651 | HSPC304 | chromosome 7 open reading frame 64 | Two-hybrid | BioGRID | 16169070 |
| CD2BP2 | FWP010 | LIN1 | Snu40 | U5-52K | CD2 (cytoplasmic tail) binding protein 2 | Affinity Capture-MS | BioGRID | 17353931 |
| CPSF6 | CFIM | CFIM68 | HPBRII-4 | HPBRII-7 | cleavage and polyadenylation specific factor 6, 68kDa | Two-hybrid | BioGRID | 16189514 |
| EXOSC6 | EAP4 | MTR3 | Mtr3p | hMtr3p | p11 | exosome component 6 | - | HPRD,BioGRID | 15231747 |
| FLJ12529 | FLJ39024 | MGC9315 | pre-mRNA cleavage factor I, 59 kDa subunit | Two-hybrid | BioGRID | 16189514 |
| KIAA1377 | - | KIAA1377 | Two-hybrid | BioGRID | 16169070 |
| MAP3K7 | TAK1 | TGF1a | mitogen-activated protein kinase kinase kinase 7 | - | HPRD | 14743216 |
| MYL6 | ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SM | myosin, light chain 6, alkali, smooth muscle and non-muscle | Two-hybrid | BioGRID | 16189514 |
| NIF3L1 | ALS2CR1 | CALS-7 | MDS015 | NIF3 NGG1 interacting factor 3-like 1 (S. pombe) | Two-hybrid | BioGRID | 16189514 |
| NUDT21 | CFIM25 | CPSF5 | DKFZp686H1588 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | Two-hybrid | BioGRID | 16189514 |
| PSMF1 | PI31 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | Two-hybrid | BioGRID | 16189514 |
| RNPS1 | E5.1 | MGC117332 | RNA binding protein S1, serine-rich domain | Affinity Capture-MS | BioGRID | 17353931 |
| RPLP1 | FLJ27448 | MGC5215 | P1 | RPP1 | ribosomal protein, large, P1 | Two-hybrid | BioGRID | 16169070 |
| SNRNP70 | RNPU1Z | RPU1 | SNRP70 | U170K | U1AP | U1RNP | small nuclear ribonucleoprotein 70kDa (U1) | Reconstituted Complex | BioGRID | 14561889 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME PROCESSING OF INTRONLESS PRE MRNAS | 14 | 6 | All SZGR 2.0 genes in this pathway |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 140 | 77 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II TRANSCRIPTION | 105 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA PROCESSING | 161 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA SPLICING | 111 | 58 | All SZGR 2.0 genes in this pathway |
| REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA | 23 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTION | 210 | 127 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA 3 END PROCESSING | 35 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | 44 | 22 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER DN | 54 | 37 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN | 164 | 111 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| LU AGING BRAIN DN | 153 | 120 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| DURCHDEWALD SKIN CARCINOGENESIS UP | 88 | 47 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS DN | 210 | 128 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D UP | 139 | 95 | All SZGR 2.0 genes in this pathway |
| MELLMAN TUT1 TARGETS DN | 47 | 29 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | 193 | 112 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM AND NORMAL AGING UP | 93 | 62 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 | 79 | 54 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 5 DN | 50 | 31 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 | 73 | 37 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |