Gene Page: ADAMTS5

Summary ?
GeneID11096
SymbolADAMTS5
SynonymsADAM-TS 11|ADAM-TS 5|ADAM-TS5|ADAMTS-11|ADAMTS-5|ADAMTS11|ADMP-2
DescriptionADAM metallopeptidase with thrombospondin type 1 motif 5
ReferenceMIM:605007|HGNC:HGNC:221|Ensembl:ENSG00000154736|HPRD:05420|Vega:OTTHUMG00000078686
Gene typeprotein-coding
Map location21q21.3
Pascal p-value0.467
Fetal beta0.669
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg136014962128339487ADAMTS55.3E-8-0.0061.38E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6687849chr1175904808ADAMTS5110960trans
rs2481653chr1176044120ADAMTS5110960.01trans
rs2502827chr1176044216ADAMTS5110968.51E-6trans
rs12405921chr1206695730ADAMTS5110960.02trans
rs17572651chr1218943612ADAMTS5110960.01trans
rs882011chr222711668ADAMTS5110960.12trans
rs16829545chr2151977407ADAMTS5110961.079E-7trans
rs3845734chr2171125572ADAMTS5110968.235E-5trans
rs7584986chr2184111432ADAMTS5110963.943E-12trans
rs6807632chr3111395567ADAMTS5110960trans
rs7681432chr456162058ADAMTS5110960.04trans
rs7664496chr456252823ADAMTS5110960.15trans
snp_a-20785690ADAMTS5110960.03trans
rs17762315chr576807576ADAMTS5110960.02trans
rs10491487chr580323367ADAMTS5110960.01trans
rs1368303chr5147672388ADAMTS5110963.288E-6trans
rs4872540chr822598980ADAMTS5110960.2trans
rs6989594chr8126303866ADAMTS5110960.07trans
rs11139334chr984209393ADAMTS5110960.07trans
rs17263352chr9124811572ADAMTS5110960.02trans
rs457696chr1332581313ADAMTS5110960.18trans
rs7996604chr1342224412ADAMTS5110960.15trans
snp_a-18805480ADAMTS5110960.14trans
rs1629937chr1477059671ADAMTS5110960.06trans
rs17104720chr1477127308ADAMTS5110961.159E-5trans
rs17104722chr1477138109ADAMTS5110960.18trans
rs17104782chr1477156735ADAMTS5110960.18trans
rs6574467chr1479179744ADAMTS5110960.17trans
rs10146003chr1479191170ADAMTS5110960.17trans
rs16955618chr1529937543ADAMTS5110961.216E-25trans
snp_a-18308940ADAMTS5110960trans
rs3743068chr1579047284ADAMTS5110960.05trans
rs17823633chr1768851458ADAMTS5110960.04trans
rs17070739chr1860819382ADAMTS5110960.13trans
rs17085767chr1869839397ADAMTS5110960.05trans
rs749043chr2046995700ADAMTS5110960.02trans
rs5955025chrX142542997ADAMTS5110960.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 9459All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158102All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 3320All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION UP 6045All SZGR 2.0 genes in this pathway
WONG ENDMETRIUM CANCER DN 8253All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC 3525All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 5944All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185116All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 11573All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229135All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169105All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 13596All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway