Gene Page: CORO1A

Summary ?
GeneID11151
SymbolCORO1A
SynonymsCLABP|CLIPINA|HCORO1|IMD8|TACO|p57
Descriptioncoronin 1A
ReferenceMIM:605000|HGNC:HGNC:2252|Ensembl:ENSG00000102879|HPRD:05414|Vega:OTTHUMG00000132148
Gene typeprotein-coding
Map location16p11.2
Pascal p-value0.001
Sherlock p-value0.481
Fetal beta-1.015
SupportSTRUCTURAL PLASTICITY
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATP5F10.870.87
TCEB10.860.87
SUPT4H10.850.86
COPS60.850.84
UQCRH0.850.85
LSM10.840.82
AC063943.40.840.84
ZDHHC40.840.80
VTI1B0.830.81
MRPL460.830.79
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.18-0.53-0.40
AF347015.26-0.52-0.42
AF347015.2-0.50-0.42
GATA2-0.49-0.47
FAM38A-0.48-0.47
PPP1R13L-0.47-0.42
AF347015.8-0.47-0.36
AF347015.15-0.46-0.38
TENC1-0.46-0.48
DOCK6-0.46-0.46

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008022protein C-terminus bindingIPI9365277 
GO:0051015actin filament bindingIDA7758584 |15601263 
GO:0042803protein homodimerization activityIDA15601263 
GO:0043548phosphoinositide 3-kinase bindingIDA11094157 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001845phagolysosome formationIMP12132654 
GO:0006928cell motionNAS17341475 
GO:0030036actin cytoskeleton organizationIMP17442961 
GO:0051126negative regulation of actin nucleationIDA17442961 
GO:0031589cell-substrate adhesionIMP17442961 
GO:0050918positive chemotaxisIDA17442961 
GO:0045087innate immune responseNAS17341475 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001891phagocytic cupIDA17442961 
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIDA17341475 
GO:0005737cytoplasmIDA17341475 
GO:0030027lamellipodiumIDA17442961 
GO:0005886plasma membraneIDA17341475 |17442961 
GO:0031410cytoplasmic vesicleIEA-
GO:0031941filamentous actinIDA15800061 
GO:0030864cortical actin cytoskeletonIDA15800061 
GO:0045335phagocytic vesicleIDA17442961 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ELVIDGE HYPOXIA DN 14694All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN 5940All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS UP 6740All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS UP 4122All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 16193All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197135All SZGR 2.0 genes in this pathway
MCBRYAN TERMINAL END BUD DN 76All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165104All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION UP 4826All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP 6647All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING 5944All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 7455All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT LATE UP 2216All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G 9562All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 17196All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 11170All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 5035All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER ES ICP WITH H3K4ME3 AND H3K27ME3 148All SZGR 2.0 genes in this pathway
MEISSNER BRAIN ICP WITH H3K4ME3 3217All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 6 3322All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K27ME3 7446All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3 3834All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP 6643All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 13785All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP 6849All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway