Gene Page: MAP4K1

Summary ?
GeneID11184
SymbolMAP4K1
SynonymsHPK1
Descriptionmitogen-activated protein kinase kinase kinase kinase 1
ReferenceMIM:601983|HGNC:HGNC:6863|Ensembl:ENSG00000104814|HPRD:03583|Vega:OTTHUMG00000180863
Gene typeprotein-coding
Map location19q13.1-q13.4
Pascal p-value0.038
Sherlock p-value0.008
Fetal beta-0.726
eGeneHypothalamus
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10486340chr719244272MAP4K1111840.02trans
rs10253642chr719250373MAP4K1111840.05trans
rs6461405chr719255956MAP4K1111840.02trans
rs10994209chr1061877705MAP4K1111840.15trans
rs9636202chr1918449237MAP4K1111840.04trans
rs12628787chr2229495372MAP4K1111840.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD,BioGRID11514608 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates Crk, an adaptor protein.BIND9891069 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD9891069 |11432831 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID9788432 |9891069 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-likeHPK1, a Ste-20 homologous serine/threonine kinase phosphorylates CrkL, a Crk-like adaptor proteinBIND9891069 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID9891069 |11279207 
DBNLABP1 | HIP-55 | SH3P7drebrin-like-HPRD,BioGRID10567356 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9346925 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2Grap2, a hematopoietic, Grb2-related adaptor protein interacts with HPK1, a Ste20-related serine/threonine kinaseBIND11313918 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2-HPRD,BioGRID11313918 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID9346925 |9788432 
|9891069 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2HPK1, a Ste-20 homologous serine/threonine kinase interacts with Grb2, an adaptor protein.BIND9891069 
HCLS1CTTNL | HS1hematopoietic cell-specific Lyn substrate 1-HPRD,BioGRID10233887 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD11487585 
MAP3K11MGC17114 | MLK-3 | MLK3 | PTK1 | SPRKmitogen-activated protein kinase kinase kinase 11-HPRD,BioGRID11053428 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD,BioGRID10224067 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Reconstituted Complex
Two-hybrid		BioGRID9346925 |9891069 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD9346925 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 3730All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES 2723All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 4638All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 6550All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY 1411All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201125All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183119All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 7746All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 11671All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE DN 3222All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME GREEN 1614All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES DN 1513All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP 166105All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP 1712All SZGR 2.0 genes in this pathway