SZGR2

Summary ?

GeneID	112476
Symbol	PRRT2
Synonyms	BFIC2\|BFIS2\|DSPB3\|DYT10\|EKD1\|FICCA\|ICCA\|IFITMD1\|PKC
Description	proline rich transmembrane protein 2
Reference	MIM:614386\|HGNC:HGNC:30500\|Ensembl:ENSG00000167371\|HPRD:13995\|Vega:OTTHUMG00000177142
Gene type	protein-coding
Map location	16p11.2
Pascal p-value	0.021
Fetal beta	-0.581
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CNV:YES	Copy number variation studies	Manual curation
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01775

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg05995267	16	29822529	PRRT2		-0.041	0.33	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0009607	response to biotic stimulus	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA DN	62	41	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP	380	215	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN	101	65	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS DN	187	109	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-132/212	649	655	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	649	655	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-133	931	937	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
				hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
				hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
				hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-150	37	43	m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-30-5p	131	138	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-495	1006	1012	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-9	933	939	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PRRT2