Gene Page: SNF8
Summary ?
| GeneID | 11267 |
| Symbol | SNF8 |
| Synonyms | Dot3|EAP30|VPS22 |
| Description | SNF8, ESCRT-II complex subunit |
| Reference | MIM:610904|HGNC:HGNC:17028|HPRD:16847| |
| Gene type | protein-coding |
| Map location | 17q21.32 |
| Pascal p-value | 3.871E-4 |
| Sherlock p-value | 0.319 |
| eGene | Cerebellum Frontal Cortex BA9 Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9904761 | 17 | 46956830 | SNF8 | ENSG00000159210.5 | 2.617E-6 | 0.01 | 65649 | gtex_brain_putamen_basal |
| rs9914918 | 17 | 46962021 | SNF8 | ENSG00000159210.5 | 1.768E-6 | 0.01 | 60458 | gtex_brain_putamen_basal |
| rs11656939 | 17 | 46964406 | SNF8 | ENSG00000159210.5 | 1.689E-6 | 0.01 | 58073 | gtex_brain_putamen_basal |
| rs7209449 | 17 | 46964758 | SNF8 | ENSG00000159210.5 | 1.668E-6 | 0.01 | 57721 | gtex_brain_putamen_basal |
| rs1973404 | 17 | 46967892 | SNF8 | ENSG00000159210.5 | 1.653E-6 | 0.01 | 54587 | gtex_brain_putamen_basal |
| rs3760451 | 17 | 46969177 | SNF8 | ENSG00000159210.5 | 1.653E-6 | 0.01 | 53302 | gtex_brain_putamen_basal |
| rs1962412 | 17 | 46970259 | SNF8 | ENSG00000159210.5 | 2.871E-6 | 0.01 | 52220 | gtex_brain_putamen_basal |
| rs962273 | 17 | 46978353 | SNF8 | ENSG00000159210.5 | 9.691E-7 | 0.01 | 44126 | gtex_brain_putamen_basal |
| rs67174000 | 17 | 46982380 | SNF8 | ENSG00000159210.5 | 9.732E-7 | 0.01 | 40099 | gtex_brain_putamen_basal |
| rs28635466 | 17 | 46983820 | SNF8 | ENSG00000159210.5 | 9.73E-7 | 0.01 | 38659 | gtex_brain_putamen_basal |
| rs71379317 | 17 | 47033201 | SNF8 | ENSG00000159210.5 | 2.394E-6 | 0.01 | -10722 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ENDOCYTOSIS | 183 | 132 | All SZGR 2.0 genes in this pathway |
| REACTOME MEMBRANE TRAFFICKING | 129 | 74 | All SZGR 2.0 genes in this pathway |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 27 | 15 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER ADVANCED VS EARLY UP | 175 | 120 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS UP | 344 | 180 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS DN | 366 | 257 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |