Summary ?
GeneID11325
SymbolDDX42
SynonymsDDX42P|RHELP|RNAHP|SF3B8|SF3b125
DescriptionDEAD-box helicase 42
ReferenceMIM:613369|HGNC:HGNC:18676|Ensembl:ENSG00000198231|HPRD:09909|Vega:OTTHUMG00000179011
Gene typeprotein-coding
Map location17q23.3
Pascal p-value0.094
Fetal beta-0.493
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg057976561761851352DDX425.1E-9-0.0132.89E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs80712011761606344DDX42ENSG00000198231.83.698E-70-244879gtex_brain_ba24
rs2017771031761614011DDX42ENSG00000198231.82.666E-70-237212gtex_brain_ba24
rs769578771761621330DDX42ENSG00000198231.82.673E-70-229893gtex_brain_ba24
rs358198071761623052DDX42ENSG00000198231.81.027E-60-228171gtex_brain_ba24
rs98964761761629692DDX42ENSG00000198231.82.67E-70-221531gtex_brain_ba24
rs65041651761630076DDX42ENSG00000198231.88.899E-80-221147gtex_brain_ba24
rs72100951761633657DDX42ENSG00000198231.82.67E-70-217566gtex_brain_ba24
rs72099611761633705DDX42ENSG00000198231.82.67E-70-217518gtex_brain_ba24
rs99068821761634382DDX42ENSG00000198231.82.799E-70-216841gtex_brain_ba24
rs99069031761634508DDX42ENSG00000198231.82.799E-70-216715gtex_brain_ba24
rs99069241761634538DDX42ENSG00000198231.82.67E-70-216685gtex_brain_ba24
rs722872781761636707DDX42ENSG00000198231.81.145E-70-214516gtex_brain_ba24
rs1852800211761636818DDX42ENSG00000198231.85.514E-70-214405gtex_brain_ba24
rs285711601761638723DDX42ENSG00000198231.82.756E-70-212500gtex_brain_ba24
rs728458751761639269DDX42ENSG00000198231.82.624E-70-211954gtex_brain_ba24
rs99067471761639694DDX42ENSG00000198231.88.671E-80-211529gtex_brain_ba24
rs1116736081761641525DDX42ENSG00000198231.82.487E-60-209698gtex_brain_ba24
rs72110551761642876DDX42ENSG00000198231.89.294E-80-208347gtex_brain_ba24
rs1385339481761644323DDX42ENSG00000198231.87.501E-70-206900gtex_brain_ba24
rs176313941761646000DDX42ENSG00000198231.89.745E-80-205223gtex_brain_ba24
rs80826511761675292DDX42ENSG00000198231.89.325E-90-175931gtex_brain_ba24
rs118717221761675576DDX42ENSG00000198231.81.906E-80-175647gtex_brain_ba24
rs98933481761676534DDX42ENSG00000198231.84.289E-80-174689gtex_brain_ba24
rs558535431761681357DDX42ENSG00000198231.82.175E-80-169866gtex_brain_ba24
rs176317831761687600DDX42ENSG00000198231.81.34E-80-163623gtex_brain_ba24
rs1114224421761692495DDX42ENSG00000198231.82.482E-70-158728gtex_brain_ba24
rs65041671761693194DDX42ENSG00000198231.84.263E-80-158029gtex_brain_ba24
rs118673961761697037DDX42ENSG00000198231.82.633E-70-154186gtex_brain_ba24
rs65041681761697469DDX42ENSG00000198231.83.77E-80-153754gtex_brain_ba24
rs118717671761698723DDX42ENSG00000198231.83.724E-80-152500gtex_brain_ba24
rs169470051761702989DDX42ENSG00000198231.86.152E-60-148234gtex_brain_ba24
rs80733731761703320DDX42ENSG00000198231.88.028E-80-147903gtex_brain_ba24
rs72208211761704147DDX42ENSG00000198231.87.883E-80-147076gtex_brain_ba24
rs116573061761704822DDX42ENSG00000198231.87.431E-70-146401gtex_brain_ba24
rs80642611761705212DDX42ENSG00000198231.81.875E-70-146011gtex_brain_ba24
rs23199901761705397DDX42ENSG00000198231.87.165E-80-145826gtex_brain_ba24
rs72123791761706122DDX42ENSG00000198231.84.987E-80-145101gtex_brain_ba24
rs1131558781761706560DDX42ENSG00000198231.81.907E-70-144663gtex_brain_ba24
rs1996495951761706939DDX42ENSG00000198231.81.879E-70-144284gtex_brain_ba24
rs3731656551761706940DDX42ENSG00000198231.81.878E-70-144283gtex_brain_ba24
rs175499541761707032DDX42ENSG00000198231.81.976E-70-144191gtex_brain_ba24
rs65041691761709145DDX42ENSG00000198231.81.875E-70-142078gtex_brain_ba24
rs65041701761709168DDX42ENSG00000198231.84.987E-80-142055gtex_brain_ba24
rs65041711761710010DDX42ENSG00000198231.87.883E-80-141213gtex_brain_ba24
rs72094351761712964DDX42ENSG00000198231.87.883E-80-138259gtex_brain_ba24
rs1131342321761715461DDX42ENSG00000198231.85.004E-80-135762gtex_brain_ba24
rs99038971761716705DDX42ENSG00000198231.87.883E-80-134518gtex_brain_ba24
rs169470141761719032DDX42ENSG00000198231.81.875E-70-132191gtex_brain_ba24
rs591223101761720281DDX42ENSG00000198231.84.373E-60-130942gtex_brain_ba24
rs72236721761720565DDX42ENSG00000198231.81.875E-70-130658gtex_brain_ba24
rs679773461761723130DDX42ENSG00000198231.81.894E-70-128093gtex_brain_ba24
rs80816121761724695DDX42ENSG00000198231.87.883E-80-126528gtex_brain_ba24
rs80692101761726032DDX42ENSG00000198231.84.292E-70-125191gtex_brain_ba24
rs2008671331761726806DDX42ENSG00000198231.81.348E-80-124417gtex_brain_ba24
rs2015753951761726807DDX42ENSG00000198231.81.762E-70-124416gtex_brain_ba24
rs80752571761728750DDX42ENSG00000198231.85.282E-80-122473gtex_brain_ba24
rs113276471761728788DDX42ENSG00000198231.82.216E-60-122435gtex_brain_ba24
rs80752731761728881DDX42ENSG00000198231.81.875E-70-122342gtex_brain_ba24
rs80802111761729882DDX42ENSG00000198231.88.128E-80-121341gtex_brain_ba24
rs99011121761730617DDX42ENSG00000198231.81.875E-70-120606gtex_brain_ba24
rs28741211761731024DDX42ENSG00000198231.81.875E-70-120199gtex_brain_ba24
rs99099921761731931DDX42ENSG00000198231.81.875E-70-119292gtex_brain_ba24
rs733375981761732576DDX42ENSG00000198231.84.987E-80-118647gtex_brain_ba24
rs80772651761732727DDX42ENSG00000198231.87.883E-80-118496gtex_brain_ba24
rs116554931761733052DDX42ENSG00000198231.81.875E-70-118171gtex_brain_ba24
rs560571981761733332DDX42ENSG00000198231.85.004E-80-117891gtex_brain_ba24
rs65041731761735056DDX42ENSG00000198231.87.883E-80-116167gtex_brain_ba24
rs80747711761735865DDX42ENSG00000198231.81.875E-70-115358gtex_brain_ba24
rs99010001761737798DDX42ENSG00000198231.81.875E-70-113425gtex_brain_ba24
rs65041741761738137DDX42ENSG00000198231.81.91E-70-113086gtex_brain_ba24
rs1846895441761740216DDX42ENSG00000198231.83.07E-70-111007gtex_brain_ba24
rs72167981761740963DDX42ENSG00000198231.87.883E-80-110260gtex_brain_ba24
rs80706501761744040DDX42ENSG00000198231.81.875E-70-107183gtex_brain_ba24
rs9924161761745905DDX42ENSG00000198231.81.875E-70-105318gtex_brain_ba24
rs99080441761747032DDX42ENSG00000198231.87.883E-80-104191gtex_brain_ba24
rs1118400271761747965DDX42ENSG00000198231.82.259E-60-103258gtex_brain_ba24
rs2008562901761747965DDX42ENSG00000198231.81.507E-70-103258gtex_brain_ba24
rs110795081761750066DDX42ENSG00000198231.81.875E-70-101157gtex_brain_ba24
rs116587401761751069DDX42ENSG00000198231.88.981E-80-100154gtex_brain_ba24
rs3978578221761752625DDX42ENSG00000198231.81.875E-70-98598gtex_brain_ba24
rs80686031761755211DDX42ENSG00000198231.87.883E-80-96012gtex_brain_ba24
rs123258661761755974DDX42ENSG00000198231.81.875E-70-95249gtex_brain_ba24
rs98997881761756384DDX42ENSG00000198231.87.883E-80-94839gtex_brain_ba24
rs349739371761760904DDX42ENSG00000198231.85.004E-80-90319gtex_brain_ba24
rs99039031761762044DDX42ENSG00000198231.87.883E-80-89179gtex_brain_ba24
rs110795091761762148DDX42ENSG00000198231.85.004E-80-89075gtex_brain_ba24
rs116583291761763031DDX42ENSG00000198231.87.883E-80-88192gtex_brain_ba24
rs99122011761763208DDX42ENSG00000198231.81.907E-70-88015gtex_brain_ba24
rs99129041761763534DDX42ENSG00000198231.81.798E-70-87689gtex_brain_ba24
rs98940901761764921DDX42ENSG00000198231.81.875E-70-86302gtex_brain_ba24
rs99015071761765524DDX42ENSG00000198231.87.883E-80-85699gtex_brain_ba24
rs169470421761766457DDX42ENSG00000198231.87.883E-80-84766gtex_brain_ba24
rs18773161761766880DDX42ENSG00000198231.83.891E-80-84343gtex_brain_ba24
rs72112131761769456DDX42ENSG00000198231.83.21E-70-81767gtex_brain_ba24
rs156371761772050DDX42ENSG00000198231.87.773E-80-79173gtex_brain_ba24
rs38331171761773516DDX42ENSG00000198231.81.957E-70-77707gtex_brain_ba24
rs38331161761774204DDX42ENSG00000198231.81.676E-60-77019gtex_brain_ba24
rs38171811761776538DDX42ENSG00000198231.82.056E-70-74685gtex_brain_ba24
rs115424361761778689DDX42ENSG00000198231.81.658E-70-72534gtex_brain_ba24
rs133808631761780793DDX42ENSG00000198231.85.158E-70-70430gtex_brain_ba24
rs2010549441761781982DDX42ENSG00000198231.83.475E-80-69241gtex_brain_ba24
rs72105501761785248DDX42ENSG00000198231.84.443E-80-65975gtex_brain_ba24
rs20132881761785904DDX42ENSG00000198231.87.407E-80-65319gtex_brain_ba24
rs116570811761792339DDX42ENSG00000198231.83.091E-80-58884gtex_brain_ba24
rs556746471761794195DDX42ENSG00000198231.85.004E-80-57028gtex_brain_ba24
rs116543351761797579DDX42ENSG00000198231.84.153E-80-53644gtex_brain_ba24
rs613603201761800392DDX42ENSG00000198231.87.407E-80-50831gtex_brain_ba24
rs118707971761804622DDX42ENSG00000198231.87.407E-80-46601gtex_brain_ba24
rs80754221761804686DDX42ENSG00000198231.83.233E-80-46537gtex_brain_ba24
rs80750611761804723DDX42ENSG00000198231.87.407E-80-46500gtex_brain_ba24
rs80755211761804954DDX42ENSG00000198231.87.407E-80-46269gtex_brain_ba24
rs72234121761808172DDX42ENSG00000198231.83.011E-60-43051gtex_brain_ba24
rs80815411761812483DDX42ENSG00000198231.87.407E-80-38740gtex_brain_ba24
rs2013919581761814196DDX42ENSG00000198231.88.011E-90-37027gtex_brain_ba24
rs80674311761817048DDX42ENSG00000198231.84.931E-70-34175gtex_brain_ba24
rs1117298491761817604DDX42ENSG00000198231.89.588E-80-33619gtex_brain_ba24
rs65041821761823672DDX42ENSG00000198231.86.174E-80-27551gtex_brain_ba24
rs116515861761825337DDX42ENSG00000198231.88.335E-70-25886gtex_brain_ba24
rs80667191761825764DDX42ENSG00000198231.81.399E-70-25459gtex_brain_ba24
rs80670641761825984DDX42ENSG00000198231.81.362E-70-25239gtex_brain_ba24
rs98910181761827856DDX42ENSG00000198231.81.409E-70-23367gtex_brain_ba24
rs72179821761832150DDX42ENSG00000198231.81.409E-70-19073gtex_brain_ba24
rs118708151761834629DDX42ENSG00000198231.88.335E-70-16594gtex_brain_ba24
rs1127098431761836936DDX42ENSG00000198231.87.004E-60-14287gtex_brain_ba24
rs116510751761837207DDX42ENSG00000198231.81.409E-70-14016gtex_brain_ba24
rs358441561761837568DDX42ENSG00000198231.88.335E-70-13655gtex_brain_ba24
rs80767171761850301DDX42ENSG00000198231.88.335E-70-922gtex_brain_ba24
rs558685061761851686DDX42ENSG00000198231.83.488E-80463gtex_brain_ba24
rs98959201761852719DDX42ENSG00000198231.86.174E-801496gtex_brain_ba24
rs116516931761853326DDX42ENSG00000198231.81.551E-802103gtex_brain_ba24
rs80788621761854068DDX42ENSG00000198231.81.409E-702845gtex_brain_ba24
rs116571201761857218DDX42ENSG00000198231.81.409E-705995gtex_brain_ba24
rs80784621761857937DDX42ENSG00000198231.81.409E-706714gtex_brain_ba24
rs110795111761858537DDX42ENSG00000198231.88.335E-707314gtex_brain_ba24
rs1120747981761859202DDX42ENSG00000198231.81.867E-607979gtex_brain_ba24
rs72211431761859348DDX42ENSG00000198231.88.335E-708125gtex_brain_ba24
rs20161721761861283DDX42ENSG00000198231.88.212E-7010060gtex_brain_ba24
rs65041861761863932DDX42ENSG00000198231.81.322E-7012709gtex_brain_ba24
rs72250921761864005DDX42ENSG00000198231.81.32E-7012782gtex_brain_ba24
rs97471641761864787DDX42ENSG00000198231.87.83E-7013564gtex_brain_ba24
rs72075691761867787DDX42ENSG00000198231.81.255E-7016564gtex_brain_ba24
rs72077681761867936DDX42ENSG00000198231.81.253E-7016713gtex_brain_ba24
rs72220601761868279DDX42ENSG00000198231.81.248E-7017056gtex_brain_ba24
rs116590131761869559DDX42ENSG00000198231.81.232E-7018336gtex_brain_ba24
rs72143121761870863DDX42ENSG00000198231.81.222E-7019640gtex_brain_ba24
rs9728751761872010DDX42ENSG00000198231.85.232E-6020787gtex_brain_ba24
rs118699321761873915DDX42ENSG00000198231.81.601E-7022692gtex_brain_ba24
rs38331151761877666DDX42ENSG00000198231.81.195E-7026443gtex_brain_ba24
rs116546511761878662DDX42ENSG00000198231.85.919E-7027439gtex_brain_ba24
rs80696871761883023DDX42ENSG00000198231.81.227E-7031800gtex_brain_ba24
rs116565751761892091DDX42ENSG00000198231.88.116E-7040868gtex_brain_ba24
rs99022751761892234DDX42ENSG00000198231.86.525E-8041011gtex_brain_ba24
rs72239661761893398DDX42ENSG00000198231.81.255E-7042175gtex_brain_ba24
rs7526211761901880DDX42ENSG00000198231.88.955E-7050657gtex_brain_ba24
rs72208921761908316DDX42ENSG00000198231.81.631E-7057093gtex_brain_ba24
rs72097581761913621DDX42ENSG00000198231.81.631E-7062398gtex_brain_ba24
rs284633111761919643DDX42ENSG00000198231.89.447E-7068420gtex_brain_ba24
rs116581751761923838DDX42ENSG00000198231.81.409E-7072615gtex_brain_ba24
rs1119110001761927819DDX42ENSG00000198231.83.722E-7076596gtex_brain_ba24
rs670185651761928055DDX42ENSG00000198231.81.631E-7076832gtex_brain_ba24
rs563836011761929968DDX42ENSG00000198231.89.447E-7078745gtex_brain_ba24
rs99040671761931549DDX42ENSG00000198231.87.68E-8080326gtex_brain_ba24
rs98994911761934384DDX42ENSG00000198231.81.631E-7083161gtex_brain_ba24
rs728487971761934664DDX42ENSG00000198231.89.447E-7083441gtex_brain_ba24
rs99142061761936147DDX42ENSG00000198231.81.206E-7084924gtex_brain_ba24
rs28542231761939014DDX42ENSG00000198231.84.609E-6087791gtex_brain_ba24
rs28542221761939015DDX42ENSG00000198231.84.609E-6087792gtex_brain_ba24
rs286554771761939237DDX42ENSG00000198231.81.17E-7088014gtex_brain_ba24
rs25845971761941284DDX42ENSG00000198231.81.643E-7090061gtex_brain_ba24
rs28542191761942682DDX42ENSG00000198231.89.447E-7091459gtex_brain_ba24
rs28542181761942940DDX42ENSG00000198231.89.447E-7091717gtex_brain_ba24
rs28542151761943869DDX42ENSG00000198231.81.376E-6092646gtex_brain_ba24
rs26658261761944924DDX42ENSG00000198231.81.179E-7093701gtex_brain_ba24
rs28542071761947107DDX42ENSG00000198231.87.05E-7095884gtex_brain_ba24
rs28541931761952633DDX42ENSG00000198231.87.608E-60101410gtex_brain_ba24
rs20061231761958669DDX42ENSG00000198231.81.533E-60107446gtex_brain_ba24
rs58214051761959727DDX42ENSG00000198231.82.555E-60108504gtex_brain_ba24
rs608324121761959732DDX42ENSG00000198231.82.193E-60108509gtex_brain_ba24
rs29552501761959740DDX42ENSG00000198231.81.548E-60108517gtex_brain_ba24
rs1120335031761960548DDX42ENSG00000198231.89.42E-70109325gtex_brain_ba24
rs346999591761960720DDX42ENSG00000198231.81.626E-60109497gtex_brain_ba24
rs30206121761960878DDX42ENSG00000198231.81.628E-60109655gtex_brain_ba24
rs27273161761961336DDX42ENSG00000198231.88.386E-70110113gtex_brain_ba24
rs27273151761961458DDX42ENSG00000198231.88.177E-70110235gtex_brain_ba24
rs26658281761961561DDX42ENSG00000198231.89.498E-70110338gtex_brain_ba24
rs27273141761961565DDX42ENSG00000198231.89.485E-70110342gtex_brain_ba24
rs27273121761962884DDX42ENSG00000198231.82.284E-60111661gtex_brain_ba24
rs1394817671761964116DDX42ENSG00000198231.86.662E-70112893gtex_brain_ba24
rs27273011761965043DDX42ENSG00000198231.84.393E-60113820gtex_brain_ba24
rs27273001761965398DDX42ENSG00000198231.81.349E-60114175gtex_brain_ba24
rs29415511761978548DDX42ENSG00000198231.83.206E-60127325gtex_brain_ba24
rs116516931761853326DDX42ENSG00000198231.85.447E-60.022103gtex_brain_putamen_basal
rs30206091761978660DDX42ENSG00000198231.81.93E-60.02127437gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SPLICEOSOME 12872All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 11466All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 7544All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway