Gene Page: U2AF2

Summary ?
GeneID11338
SymbolU2AF2
SynonymsU2AF65
DescriptionU2 small nuclear RNA auxiliary factor 2
ReferenceMIM:191318|HGNC:HGNC:23156|Ensembl:ENSG00000063244|HPRD:01872|Vega:OTTHUMG00000180908
Gene typeprotein-coding
Map location19q13.42
Pascal p-value0.051
Fetal beta0.211
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0583 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg125008841956165125U2AF27.01E-10-0.0229.76E-7DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI9447963 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0000398nuclear mRNA splicing, via spliceosomeIC9731529 
GO:0008380RNA splicingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005681spliceosomeIDA9731529 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT1D6S81E | DDX39B | UAP56HLA-B associated transcript 1U2AF65 interacts with UAP56.BIND9242493 
BEND7C10orf30 | FLJ40283 | MGC35247BEN domain containing 7Two-hybridBioGRID16189514 
C1orf190FLJ25163chromosome 1 open reading frame 190Two-hybridBioGRID16189514 
CHIC2BTL | MGC21173cysteine-rich hydrophobic domain 2Two-hybridBioGRID16189514 
DDX6FLJ36338 | HLR2 | P54 | RCKDEAD (Asp-Glu-Ala-Asp) box polypeptide 6-HPRD8816452 
DPPA2PESCRG1developmental pluripotency associated 2Two-hybridBioGRID16189514 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
KIAA0907RP11-336K24.1KIAA0907Two-hybridBioGRID16189514 
PRPF40AFBP-11 | FBP11 | FLAF1 | FLJ20585 | FNBP3 | HIP10 | HYPA | NY-REN-6PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)-HPRD15456888 
PUF60FIR | FLJ31379 | RoBPI | SIAHBP1poly-U binding splicing factor 60KDaAffinity Capture-MS
Two-hybrid		BioGRID16189514 |17353931 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1-HPRD,BioGRID9150140 |9512519 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1U2AF65 interacts with an unspecified isoform of SF1 (mBBP).BIND9512519 
SF3A2PRP11 | PRPF11 | SAP62 | SF3a66splicing factor 3a, subunit 2, 66kDaAffinity Capture-MSBioGRID12234937 
SF3B1PRP10 | PRPF10 | SAP155 | SF3b155splicing factor 3b, subunit 1, 155kDaSAP155 interacts with U2AF65.BIND9671485 
SFRS1ASF | MGC5228 | SF2 | SF2p33 | SRp30asplicing factor, arginine/serine-rich 1Two-hybridBioGRID16189514 
SFRS11DKFZp686M13204 | dJ677H15.2 | p54splicing factor, arginine/serine-rich 11-HPRD,BioGRID8816452 
SFRS2IPCASP11 | SIP1 | SRRP129splicing factor, arginine/serine-rich 2, interacting protein-HPRD,BioGRID9447963 
SIP1GEMIN2 | SIP1-deltasurvival of motor neuron protein interacting protein 1-HPRD9447963 
SRPK1SFRSK1SFRS protein kinase 1-HPRD9472028 
SRPK2FLJ36101 | SFRSK2SFRS protein kinase 2Biochemical Activity
Two-hybrid		BioGRID9472028 |16189514 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 
THAP1FLJ10477 | MGC33014THAP domain containing, apoptosis associated protein 1Two-hybridBioGRID16189514 
U2AF1DKFZp313J1712 | FP793 | RN | RNU2AF1 | U2AF35 | U2AFBPU2 small nuclear RNA auxiliary factor 1-HPRD,BioGRID1388271 
U2AF1DKFZp313J1712 | FP793 | RN | RNU2AF1 | U2AF35 | U2AFBPU2 small nuclear RNA auxiliary factor 1hU2AF(65) and hU2AF(35) interact to form the U2AF splice factor heterodimer.BIND9528748 
WT1GUD | WAGR | WIT-2 | WT33Wilms tumor 1-HPRD,BioGRID9784496 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SPLICEOSOME 12872All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 14077All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 5434All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 10554All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 16186All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING 11158All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME MRNA 3 END PROCESSING 3518All SZGR 2.0 genes in this pathway
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 4422All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR 2718All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309199All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 11070All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 11069All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING 5944All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203135All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN 2521All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 4533All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G 9562All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 6948All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL UP 1915All SZGR 2.0 genes in this pathway