Gene Page: TWF2

Summary ?
GeneID11344
SymbolTWF2
SynonymsA6RP|A6r|MSTP011|PTK9L
Descriptiontwinfilin actin binding protein 2
ReferenceMIM:607433|HGNC:HGNC:9621|Ensembl:ENSG00000247596|HPRD:08464|Vega:OTTHUMG00000158105
Gene typeprotein-coding
Map location3p21.1
Pascal p-value1.9E-5
Sherlock p-value0.799
Fetal beta-0.436
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
LK:YESGenome-wide Association StudyThis data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg03897318352272844TWF28.02E-50.4140.025DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
snp_a-42182180TWF2113440.13trans
rs584108chr1168630281TWF2113440.14trans
rs596874chr1168630873TWF2113440.06trans
rs501799chr1168631239TWF2113440.18trans
rs646586chr1168681652TWF2113440.07trans
rs478647chr1168700423TWF2113440.19trans
rs10772528chr1212210187TWF2113440.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR3BARP11 | ARP3BETA | DKFZp686O24114ARP3 actin-related protein 3 homolog B (yeast)Affinity Capture-MSBioGRID17353931 
CAPZA1CAPPA1 | CAPZ | CAZ1capping protein (actin filament) muscle Z-line, alpha 1Affinity Capture-MSBioGRID17353931 
CAPZA2CAPPA2 | CAPZcapping protein (actin filament) muscle Z-line, alpha 2Affinity Capture-MSBioGRID17353931 
CAPZBCAPB | CAPPB | CAPZ | MGC104401 | MGC129749 | MGC129750capping protein (actin filament) muscle Z-line, betaAffinity Capture-MSBioGRID17353931 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
ELOVL1CGI-88 | Ssc1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1Affinity Capture-MSBioGRID17353931 
ERC1Cast2 | ELKS | KIAA1081 | MGC12974 | RAB6IP2ELKS/RAB6-interacting/CAST family member 1Affinity Capture-MSBioGRID17353931 
KRT31HA1 | Ha-1 | KRTHA1 | MGC138630 | hHa1keratin 31Affinity Capture-MSBioGRID17353931 
KRT36HA6 | KRTHA6 | hHa6keratin 36Affinity Capture-MSBioGRID17353931 
KRT82HB2 | Hb-2 | KRTHB2keratin 82Affinity Capture-MSBioGRID17353931 
KRT85HB5 | Hb-5 | KRTHB5 | hHb5keratin 85Affinity Capture-MSBioGRID17353931 
LYARFLJ20425 | ZLYARLy1 antibody reactive homolog (mouse)Affinity Capture-MSBioGRID17353931 
VRK3-vaccinia related kinase 3Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP 5741All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153102All SZGR 2.0 genes in this pathway
WILLIAMS ESR2 TARGETS UP 2818All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
CARDOSO RESPONSE TO GAMMA RADIATION AND 3AB 1811All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181101All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway