Summary ?
GeneID1137
SymbolCHRNA4
SynonymsBFNC|EBN|EBN1|NACHR|NACHRA4|NACRA4
Descriptioncholinergic receptor nicotinic alpha 4 subunit
ReferenceMIM:118504|HGNC:HGNC:1958|Ensembl:ENSG00000101204|HPRD:00333|Vega:OTTHUMG00000033080
Gene typeprotein-coding
Map location20q13.33
Pascal p-value7.386E-4
Fetal beta0.129
eGeneCerebellar Hemisphere
Cerebellum
SupportLIGAND GATED ION SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC233723.10.840.87
SYT50.760.76
CES20.740.78
PRRT20.730.77
CCRK0.720.77
PDZD40.720.77
C11orf810.710.74
DUSP80.710.75
NUMBL0.700.75
KATNB10.700.74
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.55-0.52
MT-CO2-0.54-0.50
AF347015.31-0.53-0.49
AF347015.8-0.52-0.48
MT-CYB-0.52-0.47
AF347015.26-0.51-0.46
AF347015.27-0.51-0.48
AF347015.2-0.51-0.45
AF347015.33-0.51-0.45
AL139819.3-0.50-0.53

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0015464acetylcholine receptor activityIDANeurotransmitter (GO term level: 6)8906617 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIDA8906617 
GO:0005515protein bindingIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060080regulation of inhibitory postsynaptic membrane potentialISSneuron, Synap (GO term level: 10)-
GO:0007271synaptic transmission, cholinergicISSneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)-
GO:0014059regulation of dopamine secretionISSdopamine (GO term level: 10)-
GO:0001666response to hypoxiaIDA12189247 
GO:0001508regulation of action potentialISS-
GO:0006281DNA repairIMP16332175 
GO:0007165signal transductionIDA8906617 
GO:0007626locomotory behaviorIEA-
GO:0006816calcium ion transportISS-
GO:0006811ion transportIEA-
GO:0006811ion transportNAS8906617 
GO:0006979response to oxidative stressIMP16332175 
GO:0042113B cell activationISS-
GO:0019233sensory perception of painISS-
GO:0035095behavioral response to nicotineIMP17955458 
GO:0050890cognitionIMP14623738 
GO:0051899membrane depolarizationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005892nicotinic acetylcholine-gated receptor-channel complexIDANeurotransmitter (GO term level: 9)8906617 
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005624membrane fractionISS-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS8906617 
GO:0009897external side of plasma membraneISS-
GO:0005886plasma membraneISS-
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 1613All SZGR 2.0 genes in this pathway
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 1312All SZGR 2.0 genes in this pathway
REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 1210All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE DN 1310All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON 14976All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY 4420All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway