Gene Page: CHRNG
Summary ?
GeneID | 1146 |
Symbol | CHRNG |
Synonyms | ACHRG |
Description | cholinergic receptor nicotinic gamma subunit |
Reference | MIM:100730|HGNC:HGNC:1967|Ensembl:ENSG00000196811|HPRD:00009|Vega:OTTHUMG00000153327 |
Gene type | protein-coding |
Map location | 2q37.1 |
Pascal p-value | 0.065 |
Fetal beta | -0.604 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
DNM:Guipponi_2014 | Whole Exome Sequencing analysis | 49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 3 |
Section I. Genetics and epigenetics annotation
DNM table
Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
---|---|---|---|---|---|---|---|---|---|---|---|
CHRNG | chr2 | 233406102 | G | A | NM_005199 | . | silent | Schizophrenia | DNM:Fromer_2014 | ||
CHRNG | C | T | NM_005199 | p.Q171X | nonsense | NA | NA | Schizophrenia | DNM:Guipponi_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
EBP | 0.91 | 0.92 |
HTRA2 | 0.91 | 0.91 |
CHCHD6 | 0.91 | 0.90 |
TRAPPC4 | 0.90 | 0.89 |
EIF6 | 0.90 | 0.93 |
RRP9 | 0.89 | 0.91 |
VPS28 | 0.89 | 0.91 |
SAC3D1 | 0.88 | 0.91 |
WDR54 | 0.88 | 0.91 |
ACTL6B | 0.88 | 0.88 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.33 | -0.70 | -0.77 |
AF347015.8 | -0.70 | -0.77 |
AF347015.27 | -0.69 | -0.76 |
MT-CO2 | -0.69 | -0.74 |
MT-CYB | -0.68 | -0.76 |
AF347015.15 | -0.68 | -0.77 |
AF347015.26 | -0.68 | -0.80 |
AF347015.2 | -0.67 | -0.78 |
AF347015.31 | -0.66 | -0.72 |
AF347015.9 | -0.62 | -0.74 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0030594 | neurotransmitter receptor activity | IEA | Neurotransmitter (GO term level: 5) | - |
GO:0015464 | acetylcholine receptor activity | TAS | Neurotransmitter (GO term level: 6) | 3967651 |
GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | IEA | - | |
GO:0005216 | ion channel activity | IEA | - | |
GO:0005230 | extracellular ligand-gated ion channel activity | IEA | - | |
GO:0015267 | channel activity | TAS | 3967651 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007165 | signal transduction | TAS | 3967651 | |
GO:0006811 | ion transport | IEA | - | |
GO:0006936 | muscle contraction | TAS | 8040310 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
GO:0016021 | integral to membrane | IEA | - | |
GO:0005886 | plasma membrane | IEA | - | |
GO:0005887 | integral to plasma membrane | TAS | 3967651 | |
GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
BIOCARTA ACH PATHWAY | 16 | 13 | All SZGR 2.0 genes in this pathway |
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | All SZGR 2.0 genes in this pathway |
REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | All SZGR 2.0 genes in this pathway |
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS | 16 | 13 | All SZGR 2.0 genes in this pathway |
REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | 12 | 10 | All SZGR 2.0 genes in this pathway |
CHESLER BRAIN D6MIT150 QTL TRANS | 9 | 7 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
DELASERNA MYOD TARGETS UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN | 161 | 105 | All SZGR 2.0 genes in this pathway |
GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
MIKKELSEN MCV6 ICP WITH H3K27ME3 | 74 | 46 | All SZGR 2.0 genes in this pathway |
MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |
WANG NFKB TARGETS | 25 | 15 | All SZGR 2.0 genes in this pathway |