Summary ?
GeneID1146
SymbolCHRNG
SynonymsACHRG
Descriptioncholinergic receptor nicotinic gamma subunit
ReferenceMIM:100730|HGNC:HGNC:1967|Ensembl:ENSG00000196811|HPRD:00009|Vega:OTTHUMG00000153327
Gene typeprotein-coding
Map location2q37.1
Pascal p-value0.065
Fetal beta-0.604

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DNM:Guipponi_2014Whole Exome Sequencing analysis49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
CHRNGchr2233406102GANM_005199.silentSchizophreniaDNM:Fromer_2014
CHRNGCTNM_005199p.Q171XnonsenseNANASchizophreniaDNM:Guipponi_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EBP0.910.92
HTRA20.910.91
CHCHD60.910.90
TRAPPC40.900.89
EIF60.900.93
RRP90.890.91
VPS280.890.91
SAC3D10.880.91
WDR540.880.91
ACTL6B0.880.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.33-0.70-0.77
AF347015.8-0.70-0.77
AF347015.27-0.69-0.76
MT-CO2-0.69-0.74
MT-CYB-0.68-0.76
AF347015.15-0.68-0.77
AF347015.26-0.68-0.80
AF347015.2-0.67-0.78
AF347015.31-0.66-0.72
AF347015.9-0.62-0.74

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0015464acetylcholine receptor activityTASNeurotransmitter (GO term level: 6)3967651 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0015267channel activityTAS3967651 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS3967651 
GO:0006811ion transportIEA-
GO:0006936muscle contractionTAS8040310 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS3967651 
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
BIOCARTA ACH PATHWAY 1613All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 1613All SZGR 2.0 genes in this pathway
REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 1210All SZGR 2.0 genes in this pathway
CHESLER BRAIN D6MIT150 QTL TRANS 97All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K27ME3 7446All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206108All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280158All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 2515All SZGR 2.0 genes in this pathway