Gene Page: OSBPL5
Summary ?
| GeneID | 114879 |
| Symbol | OSBPL5 |
| Synonyms | OBPH1|ORP5 |
| Description | oxysterol binding protein like 5 |
| Reference | MIM:606733|HGNC:HGNC:16392|Ensembl:ENSG00000021762|HPRD:09475|Vega:OTTHUMG00000011702 |
| Gene type | protein-coding |
| Map location | 11p15.4 |
| Pascal p-value | 0.371 |
| Sherlock p-value | 0.394 |
| Fetal beta | 0.194 |
| DMG | 3 (# studies) |
| eGene | Cerebellar Hemisphere Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 7 |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 7 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 7 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg18897335 | 11 | 3187790 | OSBPL5 | 3.573E-4 | 0.503 | 0.042 | DMG:Wockner_2014 |
| cg18327423 | 11 | 3186549 | OSBPL5 | 2.15E-9 | -0.012 | 1.69E-6 | DMG:Jaffe_2016 |
| cg23617121 | 11 | 3121460 | OSBPL5 | 0.002 | -4.331 | DMG:vanEijk_2014 | |
| cg23617121 | 11 | 3121460 | OSBPL5 | 2.777E-4 | -5.025 | DMG:vanEijk_2014 | |
| cg18655584 | 11 | 2942093 | OSBPL5 | 0.001 | -5.657 | DMG:vanEijk_2014 | |
| cg07873128 | 11 | 3121400 | OSBPL5 | 1.407E-4 | -7.133 | DMG:vanEijk_2014 | |
| cg07873128 | 11 | 3121400 | OSBPL5 | 2.98E-5 | -7.675 | DMG:vanEijk_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10239544 | chr7 | 66897868 | OSBPL5 | 114879 | 0.12 | trans | ||
| rs958983 | chr15 | 100869139 | OSBPL5 | 114879 | 0.14 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| MORI MATURE B LYMPHOCYTE UP | 90 | 62 | All SZGR 2.0 genes in this pathway |
| LE EGR2 TARGETS DN | 108 | 84 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
| ICHIBA GRAFT VERSUS HOST DISEASE D7 DN | 40 | 22 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 | 126 | 83 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| BRIDEAU IMPRINTED GENES | 63 | 47 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |