Gene Page: C1QTNF6
Summary ?
| GeneID | 114904 |
| Symbol | C1QTNF6 |
| Synonyms | CTFP6|CTRP6|ZACRP6 |
| Description | C1q and tumor necrosis factor related protein 6 |
| Reference | MIM:614910|HGNC:HGNC:14343|Ensembl:ENSG00000133466|HPRD:12718|Vega:OTTHUMG00000150538 |
| Gene type | protein-coding |
| Map location | 22q13.1 |
| Pascal p-value | 0.048 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs760521 | chr22 | 37247850 | C1QTNF6 | 114904 | 0.06 | cis | ||
| rs1421313 | 22 | 37573429 | C1QTNF6 | ENSG00000133466.9 | 1.383E-7 | 0 | 21996 | gtex_brain_ba24 |
| rs229510 | 22 | 37573794 | C1QTNF6 | ENSG00000133466.9 | 6.895E-7 | 0 | 21631 | gtex_brain_ba24 |
| rs4821594 | 22 | 37573847 | C1QTNF6 | ENSG00000133466.9 | 3.483E-8 | 0 | 21578 | gtex_brain_ba24 |
| rs9607421 | 22 | 37575931 | C1QTNF6 | ENSG00000133466.9 | 8.281E-8 | 0 | 19494 | gtex_brain_ba24 |
| rs5756539 | 22 | 37577145 | C1QTNF6 | ENSG00000133466.9 | 8.272E-8 | 0 | 18280 | gtex_brain_ba24 |
| rs229517 | 22 | 37577737 | C1QTNF6 | ENSG00000133466.9 | 3.464E-8 | 0 | 17688 | gtex_brain_ba24 |
| rs916235 | 22 | 37578214 | C1QTNF6 | ENSG00000133466.9 | 1.943E-8 | 0 | 17211 | gtex_brain_ba24 |
| rs229520 | 22 | 37578807 | C1QTNF6 | ENSG00000133466.9 | 8.229E-8 | 0 | 16618 | gtex_brain_ba24 |
| rs4821596 | 22 | 37578995 | C1QTNF6 | ENSG00000133466.9 | 1.751E-8 | 0 | 16430 | gtex_brain_ba24 |
| rs229524 | 22 | 37579803 | C1QTNF6 | ENSG00000133466.9 | 9.588E-8 | 0 | 15622 | gtex_brain_ba24 |
| rs229525 | 22 | 37580334 | C1QTNF6 | ENSG00000133466.9 | 8.517E-9 | 0 | 15091 | gtex_brain_ba24 |
| rs734139 | 22 | 37582166 | C1QTNF6 | ENSG00000133466.9 | 1.802E-8 | 0 | 13259 | gtex_brain_ba24 |
| rs5756540 | 22 | 37582205 | C1QTNF6 | ENSG00000133466.9 | 1.751E-8 | 0 | 13220 | gtex_brain_ba24 |
| rs4820270 | 22 | 37583096 | C1QTNF6 | ENSG00000133466.9 | 1.8E-8 | 0 | 12329 | gtex_brain_ba24 |
| rs71324843 | 22 | 37583314 | C1QTNF6 | ENSG00000133466.9 | 2.821E-8 | 0 | 12111 | gtex_brain_ba24 |
| rs11330876 | 22 | 37583578 | C1QTNF6 | ENSG00000133466.9 | 1.802E-8 | 0 | 11847 | gtex_brain_ba24 |
| rs13057424 | 22 | 37584352 | C1QTNF6 | ENSG00000133466.9 | 1.813E-8 | 0 | 11073 | gtex_brain_ba24 |
| rs229532 | 22 | 37586961 | C1QTNF6 | ENSG00000133466.9 | 2.831E-8 | 0 | 8464 | gtex_brain_ba24 |
| rs229534 | 22 | 37588013 | C1QTNF6 | ENSG00000133466.9 | 2.831E-8 | 0 | 7412 | gtex_brain_ba24 |
| rs58016280 | 22 | 37588076 | C1QTNF6 | ENSG00000133466.9 | 6.423E-7 | 0 | 7349 | gtex_brain_ba24 |
| rs229535 | 22 | 37588566 | C1QTNF6 | ENSG00000133466.9 | 2.828E-8 | 0 | 6859 | gtex_brain_ba24 |
| rs2858489 | 22 | 37590203 | C1QTNF6 | ENSG00000133466.9 | 2.756E-8 | 0 | 5222 | gtex_brain_ba24 |
| rs2858490 | 22 | 37590207 | C1QTNF6 | ENSG00000133466.9 | 2.817E-8 | 0 | 5218 | gtex_brain_ba24 |
| rs229537 | 22 | 37590302 | C1QTNF6 | ENSG00000133466.9 | 2.817E-8 | 0 | 5123 | gtex_brain_ba24 |
| rs229538 | 22 | 37590718 | C1QTNF6 | ENSG00000133466.9 | 2.042E-7 | 0 | 4707 | gtex_brain_ba24 |
| rs229539 | 22 | 37591261 | C1QTNF6 | ENSG00000133466.9 | 2.065E-7 | 0 | 4164 | gtex_brain_ba24 |
| rs4140871 | 22 | 37594825 | C1QTNF6 | ENSG00000133466.9 | 2.545E-7 | 0 | 600 | gtex_brain_ba24 |
| rs229517 | 22 | 37577737 | C1QTNF6 | ENSG00000133466.9 | 9.639E-7 | 0 | 17688 | gtex_brain_putamen_basal |
| rs916235 | 22 | 37578214 | C1QTNF6 | ENSG00000133466.9 | 1.1E-6 | 0 | 17211 | gtex_brain_putamen_basal |
| rs229520 | 22 | 37578807 | C1QTNF6 | ENSG00000133466.9 | 4.821E-7 | 0 | 16618 | gtex_brain_putamen_basal |
| rs229524 | 22 | 37579803 | C1QTNF6 | ENSG00000133466.9 | 1.923E-6 | 0 | 15622 | gtex_brain_putamen_basal |
| rs229525 | 22 | 37580334 | C1QTNF6 | ENSG00000133466.9 | 3.309E-8 | 0 | 15091 | gtex_brain_putamen_basal |
| rs229532 | 22 | 37586961 | C1QTNF6 | ENSG00000133466.9 | 3.611E-8 | 0 | 8464 | gtex_brain_putamen_basal |
| rs229534 | 22 | 37588013 | C1QTNF6 | ENSG00000133466.9 | 3.611E-8 | 0 | 7412 | gtex_brain_putamen_basal |
| rs58016280 | 22 | 37588076 | C1QTNF6 | ENSG00000133466.9 | 5.389E-8 | 0 | 7349 | gtex_brain_putamen_basal |
| rs229535 | 22 | 37588566 | C1QTNF6 | ENSG00000133466.9 | 3.611E-8 | 0 | 6859 | gtex_brain_putamen_basal |
| rs2858489 | 22 | 37590203 | C1QTNF6 | ENSG00000133466.9 | 3.656E-8 | 0 | 5222 | gtex_brain_putamen_basal |
| rs2858490 | 22 | 37590207 | C1QTNF6 | ENSG00000133466.9 | 3.619E-8 | 0 | 5218 | gtex_brain_putamen_basal |
| rs229537 | 22 | 37590302 | C1QTNF6 | ENSG00000133466.9 | 3.619E-8 | 0 | 5123 | gtex_brain_putamen_basal |
| rs229538 | 22 | 37590718 | C1QTNF6 | ENSG00000133466.9 | 8.662E-8 | 0 | 4707 | gtex_brain_putamen_basal |
| rs229539 | 22 | 37591261 | C1QTNF6 | ENSG00000133466.9 | 8.711E-8 | 0 | 4164 | gtex_brain_putamen_basal |
| rs229557 | 22 | 37596333 | C1QTNF6 | ENSG00000133466.9 | 1.573E-8 | 0 | -908 | gtex_brain_putamen_basal |
| rs5995398 | 22 | 37598627 | C1QTNF6 | ENSG00000133466.9 | 4.833E-7 | 0 | -3202 | gtex_brain_putamen_basal |
| rs229564 | 22 | 37599572 | C1QTNF6 | ENSG00000133466.9 | 9.172E-7 | 0 | -4147 | gtex_brain_putamen_basal |
| rs739040 | 22 | 37599802 | C1QTNF6 | ENSG00000133466.9 | 4.96E-7 | 0 | -4377 | gtex_brain_putamen_basal |
| rs229569 | 22 | 37603051 | C1QTNF6 | ENSG00000133466.9 | 4.816E-8 | 0 | -7626 | gtex_brain_putamen_basal |
| rs86582 | 22 | 37603390 | C1QTNF6 | ENSG00000133466.9 | 4.783E-8 | 0 | -7965 | gtex_brain_putamen_basal |
| rs86583 | 22 | 37603744 | C1QTNF6 | ENSG00000133466.9 | 4.741E-8 | 0 | -8319 | gtex_brain_putamen_basal |
| rs69264 | 22 | 37603950 | C1QTNF6 | ENSG00000133466.9 | 4.721E-8 | 0 | -8525 | gtex_brain_putamen_basal |
| rs9610669 | 22 | 37607981 | C1QTNF6 | ENSG00000133466.9 | 4.574E-9 | 0 | -12556 | gtex_brain_putamen_basal |
| rs5756558 | 22 | 37608711 | C1QTNF6 | ENSG00000133466.9 | 3.266E-9 | 0 | -13286 | gtex_brain_putamen_basal |
| rs4821603 | 22 | 37609294 | C1QTNF6 | ENSG00000133466.9 | 3.276E-9 | 0 | -13869 | gtex_brain_putamen_basal |
| rs9622574 | 22 | 37610419 | C1QTNF6 | ENSG00000133466.9 | 5.644E-8 | 0 | -14994 | gtex_brain_putamen_basal |
| rs9607425 | 22 | 37611392 | C1QTNF6 | ENSG00000133466.9 | 2.884E-6 | 0 | -15967 | gtex_brain_putamen_basal |
| rs4821604 | 22 | 37611396 | C1QTNF6 | ENSG00000133466.9 | 2.916E-6 | 0 | -15971 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN | 74 | 44 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS G UP | 238 | 135 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| ROZANOV MMP14 TARGETS UP | 266 | 171 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P3 | 160 | 103 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE BY GAMMA AND UV RADIATION | 88 | 65 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE UP | 226 | 164 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K4ME3 | 128 | 68 | All SZGR 2.0 genes in this pathway |
| ZEMBUTSU SENSITIVITY TO DOXORUBICIN | 17 | 10 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 UP | 211 | 131 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| NABA ECM AFFILIATED | 171 | 89 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |