Summary ?
GeneID115265
SymbolDDIT4L
SynonymsREDD2|Rtp801L
DescriptionDNA damage inducible transcript 4 like
ReferenceMIM:607730|HGNC:HGNC:30555|Ensembl:ENSG00000145358|HPRD:09663|Vega:OTTHUMG00000161019
Gene typeprotein-coding
Map location4q24
Pascal p-value0.129
Sherlock p-value0.268
DMG2 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg003607694101110248DDIT4L4.226E-4-0.3750.045DMG:Wockner_2014
cg029896004101111617DDIT4L2.75E-11-0.0213.6E-7DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12617409chr21649924DDIT4L1152650.01trans
rs1863135chr21652821DDIT4L1152650.03trans
rs7594023chr21653884DDIT4L1152650.02trans
rs1429237chr25958773DDIT4L1152650.04trans
rs17049408chr258431128DDIT4L1152650.15trans
rs260675chr2109600118DDIT4L1152650.01trans
rs3747659chr2111744806DDIT4L1152650.02trans
rs7574824chr2130696073DDIT4L1152650trans
rs6719989chr2130737302DDIT4L1152650.19trans
rs17013713chr376105150DDIT4L1152650.18trans
rs17007390chr4124705927DDIT4L1152650.05trans
rs7734100chr538376792DDIT4L1152650.12trans
rs12055201chr557401645DDIT4L1152650.18trans
rs597544chr649703856DDIT4L1152650.06trans
rs10244048chr7100696615DDIT4L1152650.03trans
rs16904520chr8132774255DDIT4L1152650.06trans
rs16904581chr8133067536DDIT4L1152650.16trans
rs2785092chr926353892DDIT4L1152650.08trans
rs400690chr926395882DDIT4L1152650.08trans
rs16910463chr926444298DDIT4L1152650.05trans
rs10989904chr9104990393DDIT4L1152650.11trans
rs4750292chr1013016979DDIT4L1152655.697E-6trans
rs7085725chr10106060208DDIT4L1152650.07trans
rs276207chr10106065463DDIT4L1152650.07trans
rs11191996chr10106065730DDIT4L1152650.07trans
rs2282092chr10106068470DDIT4L1152650.07trans
rs17091014chr1456562713DDIT4L1152653.372E-7trans
rs9958820chr184648247DDIT4L1152650.03trans
rs1112963chr184651534DDIT4L1152650trans
rs7243836chr1865471624DDIT4L1152650.04trans
rs5920627chrX97385064DDIT4L1152650.01trans
rs2205704chrX132816690DDIT4L1152650.04trans
rs2284128chrX133096371DDIT4L1152650.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CHEBOTAEV GR TARGETS UP 7762All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209139All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F 5432All SZGR 2.0 genes in this pathway
MCGOWAN RSP6 TARGETS UP 1812All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONIC CARCINOMA VS SEMINOMA DN 2514All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS SKIN DN 2715All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway